Colorimetric sensor
First Claim
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1. A colorimetric sensor for measuring one or both of the presence and concentration of an analyte, said colorimetric sensor comprising:
- a reflective layer;
a detection layer over the reflective layer, the detection layer comprising at least one polymer component, said detection layer being capable of a change in optical thickness upon exposure to the analyte; and
a semi-reflective layer over the detection layer, the semi-reflective layer having an index of refraction different from the index of refraction of the detection layer, wherein at least a portion of (i) the semi-reflective layer, (ii) the reflective layer, or (iii) both (i) and (ii) is permeable to the analyte;
wherein the detection layer comprises a porous detection layer comprising at least one polymer having an intrinsic microporosity.
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Abstract
Colorimetric sensor films comprising a reflective layer, a polymeric detection layer, and a semi-reflective layer are disclosed. Devices comprising the colorimetric sensor films and methods of making the films and devices are also disclosed.
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Citations
38 Claims
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1. A colorimetric sensor for measuring one or both of the presence and concentration of an analyte, said colorimetric sensor comprising:
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a reflective layer; a detection layer over the reflective layer, the detection layer comprising at least one polymer component, said detection layer being capable of a change in optical thickness upon exposure to the analyte; and a semi-reflective layer over the detection layer, the semi-reflective layer having an index of refraction different from the index of refraction of the detection layer, wherein at least a portion of (i) the semi-reflective layer, (ii) the reflective layer, or (iii) both (i) and (ii) is permeable to the analyte; wherein the detection layer comprises a porous detection layer comprising at least one polymer having an intrinsic microporosity. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28)
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29. An array comprising two or more of the colorimetric sensors for measuring one or both of the presence and concentration of an analyte, said two or more colorimetric sensors each independently comprise:
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a reflective layer; a detection layer over the reflective layer, the detection layer comprising (i) at least one polymer component, (ii) at least one inorganic component, or (iii) both (i) and (ii); and a semi-reflective layer over the detection layer, the semi-reflective layer having an index of refraction different from the index of refraction of the detection layer and being permeable to said analyte, said sensor being capable of a change in color upon exposure to said analyte; wherein each of the two or more colorimetric sensors in the array shares a common reflective layer and comprises a multi-layered film island comprising a stack of layers including (i) a detection layer with a detection layer composition and (ii) a semi-reflective layer with a semi-reflective layer composition. - View Dependent Claims (30)
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31. A colorimetric sensor for measuring one or both of the presence and concentration of an analyte, said calorimetric sensor comprising:
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a reflective layer; a detection layer over the reflective layer, the detection layer comprising at least one polymer component; and a discontinuous semi-reflective layer over the detection layer, the semi-reflective layer having an index of refraction different from the index of refraction of the detection layer, said sensor being capable of a change in color upon exposure to the analyte, wherein the sensor has at least one of the following features; (a) the discontinuous semi-reflective layer comprises a single layer of semi-reflective islands having at least one dimension greater than 10 μ
m, and exposed areas between the semi-reflective islands, said exposed areas having a width of at least 1.0 μ
m;(b) the discontinuous semi-reflective layer comprises a single layer of semi-reflective islands and the detection layer contains wells extending a depth into the detection layer; (c) the discontinuous semi-reflective layer comprises a single layer of semi-reflective islands and the detection layer comprises at least one inorganic component in combination with at least one polymer component; (d) the detection layer comprises at least one inorganic component, wherein said at least one inorganic component is (i) blended with the at least one polymer component, (ii) within a given layer containing the at least one polymer component but not blended with the at least one polymer component, (iii) in a layer separate from a layer containing the at least one polymer component, or (iv) any combination of (i) to (iii); and (c) the detection layer comprises at least two different polymeric components, wherein the polymeric components are (1) blended wit one another, (2) within a given layer but not blended with one another, (3) in a layer separate from one another, or (4) any combination of (1) to (3). - View Dependent Claims (32, 33, 34, 35, 36, 37, 38)
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Specification