Anti-NGF antibodies and methods using same
First Claim
Patent Images
1. An isolated antibody comprising:
- 1) a heavy chain variable region comprising;
(a) the CDR1 region shown in SEQ ID NO;
3,(b) the CDR2 region shown in SEQ ID NO;
4, and(c) the CDR3 region shown in SEQ ID NO;
5; and
2) a light chain variable region comprising;
(a) the CDR1 region shown in SEQ ID NO;
6;
(b) the CDR2 region shown in SEQ ID NO;
7, and(c) the CDR3 region shown in SEQ ID NO;
8;
wherein the antibody binds NGF.
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Abstract
The invention concerns anti-NGF antibodies (such as anti-NGF antagonist antibodies), and polynucleotides encoding the same. The invention further concerns use of such antibodies and/or polynucleotides in the treatment and/or prevention of pain, including post-surgical pain, rheumatoid arthritis pain, and osteoarthritis pain.
179 Citations
12 Claims
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1. An isolated antibody comprising:
-
1) a heavy chain variable region comprising; (a) the CDR1 region shown in SEQ ID NO;
3,(b) the CDR2 region shown in SEQ ID NO;
4, and(c) the CDR3 region shown in SEQ ID NO;
5; and2) a light chain variable region comprising; (a) the CDR1 region shown in SEQ ID NO;
6;(b) the CDR2 region shown in SEQ ID NO;
7, and(c) the CDR3 region shown in SEQ ID NO;
8;wherein the antibody binds NGF. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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Specification