Non-invasive method and apparatus for determining onset of physiological conditions
First Claim
1. A non-invasive method of determining the value, presence or onset of a hypoglycemia condition in a patient known to be susceptible to hypoglycemia comprising the steps of:
- determining base parameters of a patient at which the onset of hypoglycemia is likely to occur, said base parameters including;
skin impedance, heart rate, QT interval, and mean or peak frequency of an alpha wave;
continuously monitoring the patient'"'"'s parameters comprising;
skin impedance, heart rate, QT interval, and mean or peak frequency of the alpha wave;
establishing whether one or more of those monitored parameters changes, and if so, the rate of change of that parameter or parameters;
feeding data obtained from said monitoring and said establishing into a neural network processor programmed with a fast learning algorithm;
comparing the data to the base parameters for that patient; and
based on said comparing, causing a signal to be generated either when said neural network establishes conditions that suggest a presence or imminent onset of a hypoglycemic condition, or when said neural network has estimated a value of said hypoglycemic condition.
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Abstract
The invention relates to the modelling and design of early warning systems for detecting medical conditions using physiological responses. The device comprises sensors for monitoring physiological parameters such as skin impedance, heart rate, and QT interval of a patient, means for establishing when those parameters change, the rate of change of the parameters, and a neural network processor for processing the information obtained by the sensors. The neural network processor is programmed with a fast learning algorithm. When the neural network establishes that a physiological condition is present in the patient an alarm signal will be generated. The invention extends to a method of non-invasive monitoring of a person using a neural network programmed with a fast learning algorithm. A non-invasive hypoglycaemia monitor is specifically described.
28 Citations
19 Claims
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1. A non-invasive method of determining the value, presence or onset of a hypoglycemia condition in a patient known to be susceptible to hypoglycemia comprising the steps of:
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determining base parameters of a patient at which the onset of hypoglycemia is likely to occur, said base parameters including;
skin impedance, heart rate, QT interval, and mean or peak frequency of an alpha wave;continuously monitoring the patient'"'"'s parameters comprising;
skin impedance, heart rate, QT interval, and mean or peak frequency of the alpha wave;establishing whether one or more of those monitored parameters changes, and if so, the rate of change of that parameter or parameters; feeding data obtained from said monitoring and said establishing into a neural network processor programmed with a fast learning algorithm; comparing the data to the base parameters for that patient; and based on said comparing, causing a signal to be generated either when said neural network establishes conditions that suggest a presence or imminent onset of a hypoglycemic condition, or when said neural network has estimated a value of said hypoglycemic condition. - View Dependent Claims (2, 3, 4, 5)
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6. An apparatus for generating an alarm when hypoglycemia is present or imminent in a patient known to be susceptible to hypoglycemia, said apparatus comprising:
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sensors for sensing a patient'"'"'s parameters comprising;
skin impedance, heart rate, QT interval, and mean or peak frequency of an alpha wave;means for establishing when one or more of the sensed parameters changes and when so established, a rate of change of that parameter or parameters; a neural network linked to said sensors and said means for establishing so as to receive a substantially continuous data stream from said sensors and said means for establishing, the neural network being programmed with a fast learning algorithm and adapted to establish when the sensed parameters, and any change to those parameters, for a particular person are such as to indicate a presence or imminent onset of a-hypoglycemic condition; and alarm means linked to said neural network and adapted to be triggered when the presence or imminent onset of said hypoglycemic condition is established. - View Dependent Claims (7, 8, 9, 10, 11, 12, 13)
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14. An apparatus for generating an alarm when hypoglycemia is present or imminent in a patient known to be susceptible to hypoglycemia, said apparatus comprising:
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sensors for sensing a patient'"'"'s parameters comprising;
skin impedance, heart rate, QT interval, and mean or peak frequency of an alpha wave;a comparator that establishes when one or more of the sensed parameters changes and when so established, a rate of change of that parameter or parameters; a neural network linked to said sensors and said comparator so as to receive a substantially continuous data stream from said sensors and said comparator, the neural network being programmed with a fast learning algorithm and adapted to establish when the sensed parameters, and any change to those parameters, for a particular person are such as to indicate a presence or imminent onset of a-hypoglycemic condition; and an alarm linked to said neural network and adapted to be triggered when the presence or imminent onset of said hypoglycemic condition is established. - View Dependent Claims (15, 16, 17, 18, 19)
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Specification