Controlling drug delivery apparatus

• US 7,451,760 B2
• Filed: 08/15/2001
• Issued: 11/18/2008
• Est. Priority Date: 02/11/2000
• Status: Expired due to Term

• Current Assignee: Respironics UK Ltd (Koninklijke Philips N.V.)
• Original Assignee: Respironics UK Ltd (Koninklijke Philips N.V.)
• Inventors: Denyer, Jonathan Stanley Harold, Dyche, Anthony, Marsden, Richard
• Primary Examiner(s): Manahan; Todd E.
• Assistant Examiner(s): Mendoza; Michael G.
• Application Number:
  US09/930,582
• Publication Number:
  US 20050229931A1
• Time in Patent Office: 2,652 Days
• Field of Search: 128/203.12, 128/203.16, 128/203.17, 128/203.26, 128/203.27, 128/203.28, 128/202.22, 128/203.14, 604/58, 600/538
• US Class Current: 128/203.12
• CPC Class Codes: A61B 5/0816 Measuring devices for examining respiratory frequency measuring frequency of electric signals G01R23/00
• CPC Class Codes: A61B 5/087 Measuring breath flow
• CPC Class Codes: A61B 5/4839 combined with drug delivery
• CPC Class Codes: A61J 1/065 Rigid ampoules, e.g. glass ampoules
• CPC Class Codes: A61J 1/067 Flexible ampoules, the contents of which are expelled by squeezing
• CPC Class Codes: A61J 1/14 Details; Accessories therefor A61J7/00 takes precedence; openers B65D, B67B7/00
• CPC Class Codes: A61J 2200/30 Compliance analysis for taking medication
• CPC Class Codes: A61J 2205/50 using icons or symbolic figures, e.g. by a graphical representation symbolising the type of pathology or the organ by an image
• CPC Class Codes: A61J 2205/60 using magnetic or electronic identifications, e.g. chips, RFID, electronic tags
• CPC Class Codes: A61J 2205/70 Audible labels, e.g. for pre-recorded info or messages
• CPC Class Codes: A61J 7/0481 working on a schedule basis
• CPC Class Codes: A61M 11/005 using ultrasonics spraying or atomising liquids using ultrasonic vibrations in general B05B17/06
• CPC Class Codes: A61M 11/06 of the injector type
• CPC Class Codes: A61M 15/0045 using multiple prepacked dosages on a same carrier, e.g. blisters
• CPC Class Codes: A61M 15/008 Electronic counters
• CPC Class Codes: A61M 2205/52 with memories providing a history of measured variating parameters of apparatus or patient
• CPC Class Codes: A61M 2205/6018 providing set-up signals for the apparatus configuration
• CPC Class Codes: G07F 17/0092 for assembling and dispensing of pharmaceutical articles medical dispensers for private use, A61J7/00
• CPC Class Codes: G16H 20/13 delivered from dispensers
• CPC Class Codes: Y02A 90/10 Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation

Abstract

A drug package comprising a plurality of drug vials containing drugs for delivery to a patient in a drug delivery device; and a data carrier including drug treatment information for use by the drug delivery apparatus.

Claims

1. A system for delivery of a drug to a patient comprising:

a drug delivery device arranged to deliver a dose of the drug to the patient over a plurality of breaths, the device including a breath analyser which

(i) analyses a patient'"'"'s breathing during drug delivery, wherein the analysis by the breath analyzer includes quantitatively measuring at least one parameter of the patient'"'"'s breathing; and

(ii) generates breath information on a patient'"'"'s breathing during drug delivery wherein the breath information includes the at least one quantitative measurement of the patient'"'"'s breathing;

a data carrier onto which the drug delivery device is arranged to place the breath information for a number of drug deliveries;

a data analyser arranged to analyze the breath information from the data carrier, and to derive characteristics of the patient'"'"'s breathing; and

a trend generator of analyzing the breath information and the characteristics of the patient'"'"'s breathing over a number of treatments, wherein the breath information includes a total treatment time, a total inhalation time and a total exhalation time, and wherein the data analyser calculates a total no flow time value by subtracting the total inhalation time and the total exhalation time from the total treatment time.

2. A system for delivery of a drug to a patient comprising:

a drug delivery device arranged to deliver a dose of the drug to the patient over a plurality of breaths, the device including a breath analyser which

(i) analyses a patient'"'"'s breathing during drug delivery, wherein the analysis by the breath analyzer includes quantitatively measuring at least one parameter of the patient'"'"'s breathing; and

(ii) generates breath information on a patient'"'"'s breathing during drug delivery wherein the breath information includes the at least one quantitative measurement of the patient'"'"'s breathing;

a data carrier onto which the drug delivery device is arranged to place the breath information for a number of treatments;

a data analyser arranged to analyze the breath information from the data carrier, and to derive characteristics of the patient'"'"'s breathing; and

a trend generator for analyzing the breath information and the characteristics of the patient'"'"'s breathing over a number of treatments, wherein the breath information includes a number of breaths per minute and a mean tidal volume, and wherein the data analyser calculates a minute volume value by dividing the number of breaths per minute by the mean tidal volume.

3. A system for delivery of a drug to a patient comprising:

a drug delivery device arranged to deliver a dose of the drug to the patient over a plurality of breaths, the device including a breath analyser which

(i) analyses a patient'"'"'s breathing during drug delivery, wherein the analysis by the breath analyzer includes quantitatively measuring at least one parameter of the patient'"'"'s breathing; and

(ii) generates breath information on a patient'"'"'s breathing during drug delivery wherein the breath information includes the at least one quantitative measurement of the patient'"'"'s breathing;

a data carrier onto which the drug delivery device is arranged to place the breath information for a number of treatments;

a data analyser arranged to analyze the breath information from the data carrier, and to derive characteristics of the patient'"'"'s breathing; and

a trend generator for analyzing the breath information and the characteristics of the patient'"'"'s breathing over a number of treatments,wherein the breath information further includes a mean inhalation flow and a mean inhalation time, and wherein the data analyser calculates a mean tidal volume value by multiplying the mean inhalation flow with the mean inhalation time with 0.7 and dividing by 60.

4. A method of identifying changes in condition of a patient over a number of treatments from a drug delivery device comprising:

analyzing a patient'"'"'s breathing during drug delivery, including quantitatively measuring at least one parameter of that breathing;

generating breath information from the patient'"'"'s breathing during drug delivery, including the quantitative measurement of that breathing;

transferring the breath information to a data analyser;

deriving characteristics of the patient'"'"'s breathing from the breath information; and

analyzing the characteristics of the patient'"'"'s treatments over a number of treatments to identify trends in those characteristics, wherein the step of quantitatively measuring at least one parameter includes a total treatment time, a total inhalation time, and a total exhalation time, and wherein the step of deriving characteristics of the patient'"'"'s breathing includes calculating a total no flow time value by subtracting the total inhalation time and the total exhalation time from the total treatment time.

5. A method of identifying changes in condition of a patient over a number of treatments from a drug delivery device comprising:

analyzing a patient'"'"'s breathing during drug delivery, including quantitatively measuring at least one parameter of that breathing;

generating breath information from the patient'"'"'s breathing during drug delivery, including the quantitative measurement of that breathing;

transferring the breath information to a data analyser;

deriving characteristics of the patient'"'"'s breathing from the breath information; and

analyzing the characteristics of the patient'"'"'s treatments over a number of treatments to identify trends in those characteristics, wherein the step of quantitatively measuring at least one parameter includes measuring a number of breaths per minute and a mean tidal volume, and wherein the step of deriving characteristics of the patient'"'"'s breathing includes calculating a minute volume value by dividing the number of breaths per minute by the mean tidal volume.

6. A method of identifying changes in condition of a patient over a number of treatments from a drug delivery device comprising:

analyzing a patient'"'"'s breathing during drug delivery, including quantitatively measuring at least one parameter of that breathing;

generating breath information from the patient'"'"'s breathing during drug delivery, including the quantitative measurement of that breathing;

transferring the breath information to a data analyser;

deriving characteristics of the patient'"'"'s breathing from the breath information; and

analyzing the characteristics of the patient'"'"'s treatments over a number of treatments to identify trends in those characteristics, wherein the step of quantitatively measuring at least one parameter further includes measuring a mean inhalation flow and a mean inhalation time, and wherein the step of deriving characteristics includes calculating a mean tidal volume value by multiplying the mean inhalation flow with the mean inhalation time with 0.7 and dividing by 60.