Arterial pressure-based, automatic determination of a cardiovascular parameter
First Claim
1. A method for determining a cardiovascular parameter of a subject comprising:
- sensing an input signal that indicates arterial blood pressure;
calculating at least one statistical moment of a first function of the input signal having an order of two or higher; and
estimating the cardiovascular parameter as a second function of at least one statistical moment of a first function of the input signal having an order greater than one.
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Accused Products
Abstract
One or more cardiovascular parameters is estimated as a function of the arterial pressure waveform, in particular, using at least one statistical moment of pressure waveform having an order greater than one. Arterial compliance, the exponential pressure decay constant, vascular resistance, cardiac output, and stroke volume are examples of cardiovascular parameters that can be estimated using various aspects of the invention. In one embodiment of the invention, not only are the first four moments (mean, standard deviation, skewness, and kurtosis) of the pressure waveform used to estimate the cardiovascular parameter(s) of interest, but also heart rate, statistical moments of a set of pressure-weighted time values, and certain anthropometric patient measurements such as age, sex, body surface area, etc.
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Citations
76 Claims
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1. A method for determining a cardiovascular parameter of a subject comprising:
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sensing an input signal that indicates arterial blood pressure; calculating at least one statistical moment of a first function of the input signal having an order of two or higher; and estimating the cardiovascular parameter as a second function of at least one statistical moment of a first function of the input signal having an order greater than one. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 52)
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37. A method for determining cardiac stroke volume comprising:
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sensing an input signal that indicates arterial blood pressure of a subject; calculating the standard deviation and kurtosis of the input signal; determining an arterial compliance value of the subject; computing an estimate of stroke volume as a function of the product of the standard deviation and the arterial compliance value, as well as of an offset factor that is proportional to the kurtosis. - View Dependent Claims (38)
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39. A system for determining a cardiovascular parameter of a subject comprising:
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a monitoring system sensing an input signal that indicates arterial blood pressure and including a processing system including; a moment-calculating module comprising computer-executable code for calculating at least one statistical moment of a first function of the input signal having an order of two or higher; and an estimation module comprising computer-executable code for estimating the cardiovascular parameter as a second function of at least one statistical moment of a first function of the input signal having an order greater than one. - View Dependent Claims (40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75)
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76. A system for determining cardiac stroke volume comprising:
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a processing system sensing an input signal that indicates arterial blood pressure of a subject; a moment-calculating module comprising computer-executable code for calculating the standard deviation and kurtosis of the input signal; an estimation module for comprising computer-executable code for determining an arterial compliance value of the subject; and
for computing an estimate of stroke volume as a function of the product of the standard deviation and the arterial compliance value, as well as of an offset factor that is proportional to the Kurtosis.
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Specification