System and method for analyte measurement using dose sufficiency electrodes
First Claim
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1. A method of determining dosage fill level in a test strip for performing a measurement on a biological fluid comprising:
- providing a biological fluid test strip, comprising;
a capillary fill chamber extending a length along the test strip from an opening to a terminus, andat least two pairs of dose sufficiency electrodes in operative communication with the chamber, each of the pairs of dose sufficiency electrodes positioned to define a respective gap between one another;
dosing the test strip with a biological fluid effective to cause the biological fluid to begin to fill the chamber;
applying a test signal to at least one electrode of each of the dose sufficiency electrode pairs;
measuring a respective response to the test signal at each of the dose sufficiency electrode pairs;
determining the dosage fill level based upon the responses.
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Abstract
A method of measuring an analyte in a biological fluid comprises applying an excitation signal having a DC component and an AC component. The AC and DC responses are measured; a corrected DC response is determined using the AC response; and a concentration of the analyte is determined based upon the corrected DC response. Other methods and devices are disclosed.
646 Citations
19 Claims
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1. A method of determining dosage fill level in a test strip for performing a measurement on a biological fluid comprising:
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providing a biological fluid test strip, comprising; a capillary fill chamber extending a length along the test strip from an opening to a terminus, and at least two pairs of dose sufficiency electrodes in operative communication with the chamber, each of the pairs of dose sufficiency electrodes positioned to define a respective gap between one another; dosing the test strip with a biological fluid effective to cause the biological fluid to begin to fill the chamber; applying a test signal to at least one electrode of each of the dose sufficiency electrode pairs; measuring a respective response to the test signal at each of the dose sufficiency electrode pairs; determining the dosage fill level based upon the responses. - View Dependent Claims (2, 3, 4)
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5. A method of determining a fill level of a biological fluid in a test strip for performing a measurement on the fluid comprising:
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providing a test strip, comprising; a fluid flow intake opening; a fluid flow terminus; at least two measurement electrodes disposed on the test strip between the opening to the terminus; and at least two pairs of dose sufficiency electrodes positioned between the measurement electrodes and the terminus, each of the pairs of dose sufficiency electrodes defining a respective gap between one another; introducing the biological fluid to the opening effective to cause the fluid to flow toward the terminus; applying a test signal to at least one electrode of each of the dose sufficiency electrode pairs; and measuring a respective response to the test signal at each of the dose sufficiency electrode pairs; determining the fill level of the biological fluid based upon the responses. - View Dependent Claims (6, 7, 8)
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9. A method of determining dosage fill rate in a biological fluid test strip comprising:
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providing a biological fluid test strip, comprising; a capillary fill chamber extending a length along the test strip from an opening to a terminus, and at least two dose sufficiency electrodes in operative communication with the chamber, the dose sufficiency electrodes positioned to define a gap between one another; dosing the test strip with a biological fluid effective to cause the biological fluid to begin to fill the chamber; applying a test signal having an AC component to at least one of the dose sufficiency electrodes; measuring a first response to the test signal at a first time; measuring a second response to the test signal at a second time; and determining a rate at which the biological fluid fills the chamber based at least in part upon the first response and the second response. - View Dependent Claims (10, 11, 12, 13)
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14. A method of determining dosage fill rate in a biological fluid test strip comprising:
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providing a biological fluid test strip, comprising; a fluid flow intake opening; a fluid flow terminus; a measurement zone positioned between the opening and the terminus, and at least two dose sufficiency electrodes positioned between the measurement zone and the terminus, the dose sufficiency electrodes positioned to define a gap between one another; dosing the test strip with a biological fluid effective to cause the biological fluid to begin to flow from the opening toward the terminus; applying a test signal having an AC component to at least one of the dose sufficiency electrodes; measuring a first response to the test signal at a first time; measuring a second response to the test signal at a second time; and determining a rate at which the biological fluid fills the chamber based at least in part upon the first response and the second response. - View Dependent Claims (15, 16, 17, 18, 19)
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Specification