Branched peptide amphiphiles, related epitope compounds and self assembled structures thereof
First Claim
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1. A non-linear peptide amphiphile compound comprising a peptide component having the formula KXXXAAAK (SEQ ID NO:
- 10), wherein X is G or L, which peptide component further has at least one pendant lysine residue coupled to a component non-linear with said peptide component, wherein the component non-linear with said peptide component is selected from IKVAV (SEQ ID NO;
3), YIGSR (SEQ ID NO;
4), RGDS (SEQ ID NO;
1), and PHSRN (SEQ ID NO;
2), wherein said peptide component is coupled to a hydrophobic component, and wherein the hydrophobic component is an alkyl moiety ranging from C6-C22.
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Abstract
Branched peptide amphiphilic compounds incorporating one or residues providing a pendant amino group for coupling one or more epitope sequences thereto, such compounds and related compositions for enhanced epitope presentation.
82 Citations
21 Claims
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1. A non-linear peptide amphiphile compound comprising a peptide component having the formula KXXXAAAK (SEQ ID NO:
- 10), wherein X is G or L, which peptide component further has at least one pendant lysine residue coupled to a component non-linear with said peptide component, wherein the component non-linear with said peptide component is selected from IKVAV (SEQ ID NO;
3), YIGSR (SEQ ID NO;
4), RGDS (SEQ ID NO;
1), and PHSRN (SEQ ID NO;
2), wherein said peptide component is coupled to a hydrophobic component, and wherein the hydrophobic component is an alkyl moiety ranging from C6-C22. - View Dependent Claims (2, 3, 4, 5, 6, 7)
- 10), wherein X is G or L, which peptide component further has at least one pendant lysine residue coupled to a component non-linear with said peptide component, wherein the component non-linear with said peptide component is selected from IKVAV (SEQ ID NO;
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8. A system comprising a non-linear peptide amphiphile compound comprising a peptide component, a hydrophobic component coupled to said peptide component at its N-terminus, said peptide component comprising a peptide of the formula KXXXAAAK (SEQ ID NO:
- 11), wherein X is L or K, further comprising at least one pendant lysine residue which is coupled to a sequence selected from IKVAV (SEQ ID NO;
3), YIGSR (SEQ ID NO;
4), RGDS (SEQ ID NO;
1), and PHSRN (SEQ ID NO;
2), wherein the hydrophobic component is an alkyl moiety ranging from C6-C22, and wherein said compound is in a fluid medium. - View Dependent Claims (9, 10, 11, 12)
- 11), wherein X is L or K, further comprising at least one pendant lysine residue which is coupled to a sequence selected from IKVAV (SEQ ID NO;
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13. A method of using a pendant lysine residue of a peptide amphiphile to present a biologically active epitope sequence, said method comprising:
- providing a plurality of peptide amphiphile compounds, each of said compounds comprising a peptide component having the formula KXXXAAAK (SEQ ID NO;
10), wherein X is G or L, and a hydrophobic component selected from an alkyl moiety ranging from C6-C22, at least one of said compounds comprising at least one pendant lysine residue; and
coupling a biologically active epitope sequence selected from IKVAV (SEQ ID NO;
3), YIGSR (SEQ ID NO;
4), RGDS (SEQ ID NO;
1), PHSRN (SEQ ID NO;
2) to said pendant lysine residue, wherein said epitope sequence is non-linear to said peptide component. - View Dependent Claims (14, 15, 16, 17, 18, 19, 20, 21)
- providing a plurality of peptide amphiphile compounds, each of said compounds comprising a peptide component having the formula KXXXAAAK (SEQ ID NO;
Specification