Bi-polar treatment facility for treating target cells with both positive and negative ions

• US 7,453,076 B2
• Filed: 03/23/2007
• Issued: 11/18/2008
• Est. Priority Date: 03/23/2007
• Status: Expired due to Fees

• Current Assignee: Nanolife Sciences, Inc.
• Original Assignee: Nanolife Sciences, Inc.
• Inventors: Welch, Larry, Winn, Ray
• Primary Examiner(s): Berman; Jack I.
• Assistant Examiner(s): Sahu; Meenakshi S
• Application Number:
  US11/690,565
• Publication Number:
  US 20080234531A1
• Time in Patent Office: 606 Days
• Field of Search: 250/396.R, 250/310, 250/396.ML, 250/398, 250/397, 250/492.3, 250/492.1, 250/394, 250/493.1, 315/501, 315/502, 315/5.41, 378/65, 378/137, 376/127, 376/156, 313/62, 600/1, 600/427
• US Class Current: 250/492.3
• CPC Class Codes: A61N 2005/1087 Ions; Protons
• CPC Class Codes: A61N 5/10 X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy A61N5/01 takes precedence

Abstract

A system for treating target cells with both positive and negative ions comprises a bi-polar beam delivery system configured to create and deliver both positive ion beams and negative ion beams. The bi-polar beam delivery system comprises a bi-polar accelerator configured to accelerate positive and negative ions in the same direction making such a bi-polar beam delivery system practical.

Claims

1. A bi-polar charged particle beam delivery system, comprising:

a bi-polar accelerator configured to accelerate positive and negative ions in the same direction, the bi-polar accelerator comprising;

a plurality of arced sections, and

a plurality of bending magnets configured to direct the positive and negative ions around the arced section in the same direction; and

a configurable power supply coupled with the plurality of bending magnets, the configurable power supply configured to supply a reversible current to the bending magnets.

2. The bi-polar beam delivery system of claim 1, wherein the plurality of bending magnets are configured to use the current supplied by the configurable power supply to generate a magnetic field.

3. The bi-polar beam delivery system of claim 2, wherein the configurable power supply comprises a control input configured to receive an input and cause the configurable power supply to reverse the direction of the current supplied to the bending magnets, which in turn causes a polarity associated with the magnetic fields generated by the plurality of bending magnets to be reversed.

4. The bi-polar beam delivery system of claim 1, wherein the bi-polar accelerator is a synchrotron.

5. The bi-polar beam delivery system of claim 1, wherein the bi-polar accelerator is a cyclotron.

6. The bi-polar beam delivery system of claim 1, wherein the bi-polar accelerator is a synchrocyclcotron.

7. The bi-polar beam delivery system of claim 1, wherein the bi-polar accelerator is a Fixed Field Alternating Gradient (FFAG) accelerator.

8. The bi-polar beam delivery system of claim 1, wherein the bi-polar accelerator comprises a dual function injection port configured to supply both positive and negative ions to the bi-polar accelerator.

9. The bi-polar beam delivery system of claim 8, wherein the dual function injector port comprises a positive ion pathway;

a negative ion pathway and a magnetic control configured to allow positive ions or negative ions to be injected into the bi-polar accelerator as required.

10. The bi-polar beam delivery system of claim 9, wherein the negative ion pathway is configured to receive negative ions from a negative ion production facility.

11. The bi-polar beam delivery system of claim 9, wherein the positive ion pathway is configured to receive positive ions from a positive ion production facility.

12. The bi-polar beam delivery system of claim 9, wherein the negative ion pathway is configured to receive negative ions from a negative ion containment device.

13. The bi-polar beam delivery system of claim 9, wherein the positive ion channel is configured to receive positive ions from a positive ion containment device.

14. The bi-polar beam delivery system of claim 1, wherein the negative ions are antiprotons.

15. The bi-polar beam delivery system of claim 1, wherein the positive ions are protons.

16. A bi-polar treatment facility, comprising:

a bi-polar beam delivery system, the bi-polar beam delivery system comprising;

a bi-polar accelerator configured to accelerate positive and negative ions in the same direction, the bi-polar accelerator comprising;

a plurality of arced sections, and

a plurality of bending magnets configured to direct the positive and negative ions around the arced sections in the same direction and form a beam comprising the positive or negative ions, and

a configurable power supply coupled with the plurality of bending magnets, the configurable power supply configured to supply a reversible current to the bending magnets; and

a radiating and imaging device, the radiating and imaging device comprising;

a beam delivery gantry configured to deliver the beam to a target area.

17. The bi-polar treatment facility of claim 16, wherein the gantry comprises a particle beam delivery pipe coupled with the bi-polar accelerator.

18. The bi-polar treatment facility of claim 17, wherein the gantry further comprises a gantry head configured to direct the beam to the target area.

19. The bi-polar treatment facility of claim 17, wherein the gantry head comprises a monitoring system configured to monitor how many positive or negative ions are delivered to the target area.

20. The bi-polar treatment facility of claim 17, wherein the gantry further comprises one or more bending magnets configured to direct the beam around bends in the delivery pipe.

21. The bi-polar treatment facility of claim 20, wherein the plurality of bending magnets in the gantry are configured to produce a magnetic field, and wherein the plurality of bending magnets in the gantry are configured so that the polarity of the magnet field can be reversed as required to direct positive or negative ions around the bends.

22. The bi-polar treatment facility of claim 16, wherein the radiating and imaging device further comprises real-time imaging systems for imaging the application of positive and negative ions to a target mass in the target area.

23. The bi-polar treatment facility of claim 16, wherein the radiating and imaging device further comprises a range shifter configured to control the depth of a dose applied to the target area.

24. The bi-polar treatment facility of claim 16, wherein the radiating and imaging device is configured to scan at least one of the positive and negative ions across a patient'"'"'s body, to vary a dose as a function of position in a plane perpendicular to the forward motion of the ions as they are being scanned.

25. The bi-polar treatment facility of claim 22, wherein the real-time imaging system comprises a plurality of detectors configured to image the target area during treatment.

26. The bi-polar treatment facility of claim 25, wherein the plurality of detectors are configured to image the treatment area during the application of negative ions by being exposed to annihilation emissions from the treatment area that occur during the delivery of negative ions to the target area.

27. The bi-polar treatment facility of claim 16, further comprising a treatment protocol station configured to determine a treatment protocol defining the application of positive and negative ions to the treatment area.

28. The bi-polar treatment facility of claim 27, wherein the treatment protocol station is configured to control the configurable power supply so as to reverse the current supplied by the configurable power supply as required to accelerate positive or negative ions in the bi-polar accelerator.

29. The bi-polar treatment facility of claim 27, wherein the treatment protocol station is configured to receive real-time information related to the application of positive and negative ions to the treatment area, and wherein the treatment protocol station is configured to use the real-time information to adjust the treatment protocol.

30. The bi-polar treatment facility of claim 29, wherein the real-time information is related to the number of positive ions being delivered to the treatment area during an application.

31. The bi-polar treatment facility of claim 30, wherein the real-time information is related to the number of negative ions being delivered to the treatment area during an application.

32. The bi-polar treatment facility of claim 29, wherein the real-time information is real-time image information of the treatment area.