Trained and adaptive response in a neurostimulator
First Claim
1. A method of providing electrical neurostimulation therapy to a patient using, at least in part, an implanted neurostimulator, said method comprising:
- sensing at least two physiological parameters in the body of a patient selected from the group consisting of an action potential in a cranial nerve, a heart parameter, a temperature, and a blood parameter;
for each of said at least two physiological parameters, generating a first series of signals representative of the physiological parameter sensed over a first time period;
storing each of said first series of signals as a time sequence data stream representative of said physiological parameter;
determining when a physiological event has occurred in said patient;
providing an indication of the occurrence of said physiological event;
analyzing each of said time sequence data streams for a predetermined time interval preceding said event to determine at least one marker in said data streams as a predictor of said event;
again sensing said at least two physiological parameters in said patient;
for each of said at least two physiological parameters, generating a second series of signals representative of the physiological parameter sensed;
analyzing each of said second series of signals to determine whether or not said at least one marker is present; and
providing an electrical pulse from said implanted neurostimulator to a cranial nerve in the patient when said marker is present in said second series of signals.
2 Assignments
0 Petitions
Accused Products
Abstract
A method sensing at least two physiological parameters and, for each of the at least two physiological parameters, generating a first series of signals representative of the physiological parameter sensed over a first time period, storing each of said first series of signals as a time sequence data stream, and determining when a physiological event has occurred in a patient. The method further comprises analyzing each of said time sequence data streams for a predetermined time interval preceding the occurrence of a physiological event to determine at least one marker as a predictor of the event, and again sensing the physiological parameters. Furthermore, the method comprises generating a second series of signals representative of the physiological parameter sensed, analyzing each of the second series of signals to determine whether the marker is present, and stimulating a cranial nerve when the marker is present in the second series of signals.
-
Citations
27 Claims
-
1. A method of providing electrical neurostimulation therapy to a patient using, at least in part, an implanted neurostimulator, said method comprising:
-
sensing at least two physiological parameters in the body of a patient selected from the group consisting of an action potential in a cranial nerve, a heart parameter, a temperature, and a blood parameter; for each of said at least two physiological parameters, generating a first series of signals representative of the physiological parameter sensed over a first time period;
storing each of said first series of signals as a time sequence data stream representative of said physiological parameter;determining when a physiological event has occurred in said patient; providing an indication of the occurrence of said physiological event; analyzing each of said time sequence data streams for a predetermined time interval preceding said event to determine at least one marker in said data streams as a predictor of said event; again sensing said at least two physiological parameters in said patient; for each of said at least two physiological parameters, generating a second series of signals representative of the physiological parameter sensed; analyzing each of said second series of signals to determine whether or not said at least one marker is present; and providing an electrical pulse from said implanted neurostimulator to a cranial nerve in the patient when said marker is present in said second series of signals. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
-
- 12. The method 1 further comprising storing a timestamp with each stored time sequence data stream.
-
14. A method of providing electrical neurostimulation therapy to a patient using, at least in part, an implanted neurostimulator, said method comprising:
-
sensing at least two non-electroencephalogram (non-EEG) physiological parameters in the body of said patient selected from the group consisting of an action potential in a cranial nerve, a heart parameter, a temperature, and a blood parameter; for each of said at least two physiological parameters, generating a first series of signals representative of the physiological parameter sensed over a first time period; generating a first time sequence data stream representative of said physiological parameter; determining whether a physiological event has occurred in said patient based upon said first series of signal; determining at least one marker in said data stream based upon a correlation of said first time sequence data stream and said physiological event, said marker being a predictor of said event; generating a second series of signals representative of said physiological parameter in the body of said patient based upon a subsequent sensing of said at least two physiological parameter; determining whether said at least one marker is present in the second series of signals; and providing a pulsed electrical signal in said patient from said implanted neurostimulator to a vagus nerve in the patient when said marker is present in said second series of signals. - View Dependent Claims (15, 16, 17, 18, 19, 20, 21, 22, 23, 24)
-
- 25. The method 14 further comprising storing a timestamp with each stored time sequence data stream.
-
27. A method of providing electrical neurostimulation therapy to a patient using an implanted neurostimulator, said method comprising:
-
sensing at least two physiological parameters selected from the group consisting of an action potential in a cranial nerve, a heart parameter, a temperature, and a blood parameter, said sensing performed by said implanted neurostimulator; for each of said at least two physiological parameters, said implanted neurostimulator generating a first series of signals representative of the physiological parameter sensed over a first time period; generating, by said implanted neurostimulator, a first time sequence data stream representative of said physiological parameter; determining, by said implanted neurostimulator, whether a physiological event has occurred in a patient based upon said first series of signal; determining, by said implanted neurostimulator, at least one marker in said data stream based upon a correlation of said first time sequence data stream and said physiological event, said marker being a predictor of said event; generating, by said implanted neurostimulator, a second series of signals representative of said physiological parameter based upon a subsequent sensing of said at least two physiological parameter; determining, by said implanted neurostimulator, whether said at least one marker is present in the second series of signals; and providing, by said implanted neurostimulator, a pulsed electrical signal from said implanted neurostimulator to a cranial nerve in the patient when said marker is present in said second series of signals.
-
Specification