Multiplex decoding of array sensors with microspheres
First Claim
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1. A method of decoding an array, said method comprising:
- a) providing an array comprising sites, said sites having a bioactive agent and a combination of different identifier binding ligands (IBLs) randomly distributed thereon;
b) adding a first decoder binding ligand (DBL) to the array, wherein the first DBL binds to an IBL in said combination;
c) identifying the position of the IBL that binds to the first DBL;
d) adding a second DBL to the array, wherein the second DBL binds to another IBL in said combination;
e) identifying the position of the IBL that binds to the second DBL; and
f) decoding the position of said bioactive agent on said array based on the position on the array of the IBLs that bind the first and the second DBLs.
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Abstract
The invention relates to compositions and methods for multiplex decoding of microsphere array sensors.
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Citations
11 Claims
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1. A method of decoding an array, said method comprising:
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a) providing an array comprising sites, said sites having a bioactive agent and a combination of different identifier binding ligands (IBLs) randomly distributed thereon; b) adding a first decoder binding ligand (DBL) to the array, wherein the first DBL binds to an IBL in said combination; c) identifying the position of the IBL that binds to the first DBL; d) adding a second DBL to the array, wherein the second DBL binds to another IBL in said combination; e) identifying the position of the IBL that binds to the second DBL; and f) decoding the position of said bioactive agent on said array based on the position on the array of the IBLs that bind the first and the second DBLs. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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Specification