Retrograde atrial sensing for identifying sub-threshold atrial pacing

• US 7,457,666 B2
• Filed: 05/25/2005
• Issued: 11/25/2008
• Est. Priority Date: 05/25/2005
• Status: Expired due to Fees

• Current Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Original Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Inventors: Bohn, Derek D., Gandhi, Rajesh K.
• Primary Examiner(s): Layno; Carl H.
• Assistant Examiner(s): Heller; Tammie K.
• Application Number:
  US11/136,988
• Publication Number:
  US 20060271122A1
• Time in Patent Office: 1,280 Days
• Field of Search: 607/9, 607/14, 607/27, 607/28
• US Class Current: 607/27
• CPC Class Codes: A61N 1/368 comprising more than one electrode co-operating with different heart regions A61N1/3622, A61N1/3627 take precedence
• CPC Class Codes: A61N 1/3712 Auto-capture, i.e. automatic adjustment of the stimulation threshold
• CPC Class Codes: A61N 1/3714 Atrial capture

Abstract

Methods and systems for delivering a pacing pulse to an atrium during a cardiac cycle. A retrograde P-wave may be identified during the cardiac cycle, indicative of sub-threshold atrial pacing. Delivery of the pacing pulse to the atrium may be adjusted in a subsequent cardiac cycle in response to identifying the retrograde P-wave. Adjusting delivery of the pacing pulse may involve initiating an atrial capture threshold test, temporarily increasing one or both of the pacing pulse amplitude and pulse width, and/or re-evaluating one or both of the pacing pulse amplitude and pulse width. Adjusting delivery of the pacing pulse may also involve altering the timing of a scheduled atrial capture threshold test. During an atrial capture threshold test, a retrograde P-wave template may be generated in response to atrial non-capture sensed during the atrial capture threshold test, and used to identify subsequent retrograde P-waves.

Claims

1. A method of detecting sub-threshold atrial pacing, comprising:

performing an atrial capture threshold test;

generating a retrograde P-wave template in response to atrial non-capture identified during the atrial capture threshold test;

delivering a pacing pulse to an atrium during a cardiac cycle;

identifying a retrograde P-wave during the cardiac cycle using the generated retrograde P-wave template, the retrograde P-wave indicative of sub-threshold atrial pacing; and

adjusting delivery of the pacing pulse to the atrium in a subsequent cardiac cycle in response to identifying the retrograde P-wave.

2. The method of claim 1, wherein adjusting delivery of the pacing pulse comprises initiating an atrial capture threshold test.

3. The method of claim 1, wherein adjusting delivery of the pacing pulse comprises re-evaluating one or both of the pacing pulse amplitude and pulse width.

4. The method of claim 1, wherein identifying the retrograde P-wave comprises determining one or more of the frequency content, amplitude, slew rate, and timing of an atrial response.

5. The method of claim 1, comprising confirming presence of the retrograde P-wave prior to adjusting delivery of the pacing pulse.

6. The method of claim 1, wherein adjusting delivery of the pacing pulse comprises temporarily increasing one or both of the pacing pulse amplitude and pulse width.

7. The method of claim 1, wherein identifying the retrograde P-wave comprises sensing an atrial response during a post ventricular atrial refractory period.

8. The method of claim 1, wherein identifying the retrograde P-wave comprises sensing an atrial response within a range of about 50 milliseconds and about 300 milliseconds after a ventricular pace.

9. The method of claim 1, wherein adjusting delivery of the pacing pulse comprises altering the timing of a scheduled atrial capture threshold test.

10. A cardiac system, comprising:

a plurality of implantable electrodes configured for one or both of sensing a cardiac signal and delivering cardiac pacing pulses to a patient;

a housing configured for implantation in the patient;

memory; and

a controller provided in the housing and coupled to the plurality of implantable electrodes, the controller configured to execute program instructions stored in the memory, wherein controller execution of the stored program instructions cause the cardiac system to perform an atrial capture threshold test, generate a retrograde P-wave template in response to atrial non-capture identified during the atrial capture threshold test, deliver a pacing pulse to an atrium of the patient'"'"'s heart during a cardiac cycle, identify a retrograde P-wave indicative of sub-threshold atrial pacing during the cardiac cycle using the generated retrograde P-wave template, and adjust delivery of the pacing pulse to the atrium in a subsequent cardiac cycle in response to identifying the retrograde P-wave.

11. The cardiac system of claim 10, wherein the controller is configured to initiate an atrial capture threshold test in response to identifying the retrograde P-wave.

12. The cardiac system of claim 10, wherein the controller is configured to re-evaluate one or both of the pacing pulse amplitude and pulse width in response to identifying the retrograde P-wave.

13. The cardiac system of claim 10, wherein the controller is configured to determine one or more of the frequency content, amplitude, slew rate, and timing of an atrial response in order to identify the retrograde P-wave.

14. The cardiac system of claim 10, wherein the controller is configured to confirm presence of the retrograde P-wave prior to adjusting delivery of the pacing pulse.

15. The cardiac system of claim 10, wherein the controller is configured to temporarily increase one or both of the pacing pulse amplitude and pulse width in response to identifying the retrograde P-wave.

16. The cardiac system of claim 10, wherein the controller is configured to sense for the retrograde P-wave during a post ventricular atrial refractory period.

17. A cardiac system, comprising:

means for performing an atrial capture threshold test;

means for generating a retrograde P-wave template in response to atrial non-capture identified during the atrial capture threshold test;

means for delivering a pacing pulse to an atrium during a cardiac cycle;

means for identifying a retrograde P-wave during the cardiac cycle using the generated retrograde P-wave template to identify the retrograde P-wave, the retrograde P-wave indicative of sub-threshold atrial pacing; and

means for adjusting delivery of the pacing pulse to the atrium in a subsequent cardiac cycle in response to identifying the retrograde P-wave.