High viscosity embolizing compositions comprising prepolymers
First Claim
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1. A method for embolizing a vascular site, said method comprising:
- (a) selecting an embolic composition comprisinga cyanoacrylate prepolymer and/or partially reacted monomers and oligomers thereof;
a biocompatible contrast agent, in an amount capable of being monitored during injection; and
a thickening agent which is a polyacrylate polymer,wherein the viscosity of said composition prior to injection is at least about 150 centistokes at 40°
C.;
(b) transferring the embolic composition to a delivery catheter having a proximal end and a distal end, wherein the distal end of the delivery catheter is positioned at the vascular site to be embolized; and
(c) injecting the embolic composition into said vascular site in sufficient amounts to embolize said vascular site.
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Abstract
Disclosed are novel high viscosity compositions for embolizing blood vessels which comprise a biocompatible prepolymer and a contrast agent, and optionally a thickening agent and/or a biocompatible solvent. Also disclosed are methods for embolizing a vascular site by injecting high viscosity prepolymer compositions into said site. The disclosed compositions and methods are particularly well suited for the treatment of aneurysms.
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Citations
14 Claims
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1. A method for embolizing a vascular site, said method comprising:
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(a) selecting an embolic composition comprising a cyanoacrylate prepolymer and/or partially reacted monomers and oligomers thereof; a biocompatible contrast agent, in an amount capable of being monitored during injection; and a thickening agent which is a polyacrylate polymer, wherein the viscosity of said composition prior to injection is at least about 150 centistokes at 40°
C.;(b) transferring the embolic composition to a delivery catheter having a proximal end and a distal end, wherein the distal end of the delivery catheter is positioned at the vascular site to be embolized; and (c) injecting the embolic composition into said vascular site in sufficient amounts to embolize said vascular site. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14)
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Specification