Modification of feeding behavior
First Claim
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1. A method for decreasing calorie intake, food intake or appetite, in a human subject in need thereof, comprising peripherally administering prior to a meal to said subject PYY3-36 (SEQ ID NO:
- 334) in a dose of from 5 to 100 nmoles per 70 to 75 kg body weight of said subject.
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Abstract
Methods are disclosed for decreasing calorie intake, food intake, and appetite in a subject. The methods include peripherally administering a therapeutically effective amount of PYY or an agonist thereof to the subject, thereby decreasing the calorie intake of the subject.
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Citations
18 Claims
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1. A method for decreasing calorie intake, food intake or appetite, in a human subject in need thereof, comprising peripherally administering prior to a meal to said subject PYY3-36 (SEQ ID NO:
- 334) in a dose of from 5 to 100 nmoles per 70 to 75 kg body weight of said subject.
- View Dependent Claims (4, 5, 6, 7, 9, 10, 11, 12, 13, 14, 16)
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2. A method for decreasing calorie intake, food intake or appetite, in a human subject in need thereof, comprising peripherally administering prior to a meal to said subject PYY3-36 (SEQ ID NO:
- 334) in a dosage of from about 45 to about 135 pmol per kilogram body weight of said subject.
- View Dependent Claims (3)
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8. A method for treating obesity in a human subject in need of treatment comprising peripherally administering prior to a meal to said subject PYY3-36 (SEQ ID NO:
- 334) in a dose of from 5 to 100 nmoles per 70-75 kg body weight of said subject.
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15. A method for decreasing calorie intake, food intake or appetite, in a human subject in need thereof, comprising administering prior to a meal to said subject PYY3-36 (SEQ ID NO:
- 334) in a dose of from 5 to 100 nmoles per 70 to 75 kg body weight of said subject by a rectal, intravenous, intramuscular, intranasal, intraperitoneal, intravaginal, transmucosal, sublingual or buccal route, or by pulmonary inhalation.
- View Dependent Claims (18)
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17. A method for treating obesity in a human subject in need thereof, comprising administering prior to a meal to said subject PYY3-36 (SEQ ID NO:
- 334) in a dose of from 5 to 100 nmoles per 70 to 75 kg body weight of said subject by a rectal, intravenous, intramuscular, intranasal, intraperitoneal, intravaginal, transmucosal, sublingual or buccal route, or by pulmonary inhalation.
Specification