Method for providing a cathartic effect

• US 7,459,583 B2
• Filed: 07/28/2005
• Issued: 12/02/2008
• Est. Priority Date: 05/18/2001
• Status: Expired due to Term

• Current Assignee: Sucampo AG (Mallinckrodt plc)
• Original Assignee: Sucampo AG (Mallinckrodt plc)
• Inventors: Ueno, Ryuji
• Primary Examiner(s): STOCKTON, LAURA LYNNE
• Application Number:
  US11/190,842
• Publication Number:
  US 20050261375A1
• Time in Patent Office: 1,223 Days
• Field of Search: 562/503
• US Class Current: 562/503
• CPC Class Codes: A61K 31/5575 having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
• CPC Class Codes: A61P 1/10 Laxatives
• CPC Class Codes: C07C 405/00 Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof

Abstract

The present invention relates to a novel method for providing a cathartic effort to a patient in need of cathartic induction, which comprises administering to the patient a cathartic-inducing effective amount of halogenated bioactive lipid comprising the following patial structure (I):

The method is useful for relieving or preventing constipation, and also for cleansing the gastrointestinal tract.

Claims

1. A compound represented by the formula (IV):

2. The compound as described in claim 1, wherein said compound is 13,14-dihydro-16,16-difluoro-prostaglandin E1.

3. The compound as described in claim 1, wherein X₁′

and X₂′

are fluorine atoms.