Method and apparatus for detecting ischemia using changes in QRS morphology

• US 7,460,900 B1
• Filed: 09/14/2005
• Issued: 12/02/2008
• Est. Priority Date: 09/14/2005
• Status: Expired due to Fees

• Current Assignee: Pacesetter Incorporated (Abbott Laboratories Incorporated)
• Original Assignee: Pacesetter Incorporated (Abbott Laboratories Incorporated)
• Inventors: Boileau, Peter, Gill, Jong, Bornzin, Gene A.
• Primary Examiner(s): Layno; Carl H.
• Assistant Examiner(s): Morales; Jon-Eric C
• Application Number:
  US11/227,856
• Time in Patent Office: 1,175 Days
• Field of Search: 607/17, 607/14, 600/509
• US Class Current: 600/509
• CPC Class Codes: A61B 5/024 Detecting, measuring or recording pulse rate or heart rate A61B5/0205, A61B5/021 take precedence
• CPC Class Codes: A61B 5/35 by template matching
• CPC Class Codes: A61N 1/3627 for treating a mechanical deficiency of the heart, e.g. congestive heart failure or cardiomyopathy
• CPC Class Codes: A61N 1/36507 controlled by gradient or slope of the heart potential

Abstract

A method for operating an implantable medical device includes determining the difference of the absolute value of the voltage of a test QRS complex and the voltage of a baseline QRS template at a plurality of corresponding sample points and detecting ischemia if the sum of the differences at the plurality of sample points is greater than an ischemia detection threshold.

Claims

1. A method for detecting ischemia, comprising:

generating a baseline QRS template;

determining absolute value of difference of voltage of a test QRS complex and voltage of the baseline QRS template at a plurality of sample points; and

detecting ischemia if a sum of the differences at the plurality of sample points is greater than an ischemia detection threshold.

2. The method of claim 1 wherein generating a baseline QRS template comprises generating an ensemble average of a plurality of digitized baseline QRS complexes.

3. The method of claim 1 further comprising aligning the test QRS complex with the baseline QRS template.

4. The method of claim 1 wherein aligning the test QRS complex with the baseline QRS template comprises aligning maximum amplitude of the test QRS complex with maximum amplitude of the baseline QRS template.

5. The method of claim 1 further comprising generating and storing an ischemia burden metric.

6. The method of claim 1 further comprising adjusting cardiac pacing parameters to increase heart perfusion in response to detection of ischemia.

7. The method of claim 1 wherein generating a baseline QRS template comprises generating a baseline QRS template at each of a plurality of heart rates.

8. The method of claim 7 further comprising determining current heart rate and wherein determining total difference of absolute value of amplitude of a test QRS complex and amplitude of the baseline QRS template at a plurality of sample points comprises determining total difference of absolute value of amplitude of a test QRS complex and amplitude of the baseline QRS template corresponding to the current heart rate.

9. The method of claim 1 further comprising notifying patient of detection of ischemia.

10. The method of claim 1 wherein generating a baseline QRS template comprises generating a baseline QRS template for each of a plurality of sensing vectors and wherein determining total difference of absolute value of amplitude of a test QRS complex and amplitude of the baseline QRS template at a plurality of sample points comprises determining total difference of absolute value of amplitude of a test QRS complex sensed with each of the plurality of sensing vectors with the amplitude of the corresponding baseline QRS template for that sensing vector.

11. The method of claim 10 wherein detecting ischemia if the absolute value of the difference is greater than an ischemia detection threshold comprises detecting ischemia if the absolute value of the difference for each of the plurality of sensing vectors is greater than an ischemia detection threshold.

12. The method of claim 1 wherein generating a baseline QRS template comprises generating a short term moving average of a plurality of digitized baseline QRS complexes.

13. The method of claim 1 wherein generating a baseline QRS template comprises generating a long term moving average of a plurality of digitized baseline QRS complexes.

14. An implantable medical device, comprising:

means for generating a baseline QRS template;

means for determining absolute value of difference of voltage of a test QRS complex and voltage of the baseline QRS template at a plurality of sample points; and

means for detecting ischemia if a sum of the differences at the plurality of sample points is greater than an ischemia detection threshold.

15. The implantable medical device of claim 14 wherein the means for generating a baseline QRS template comprises means for generating an ensemble average of a plurality of digitized baseline QRS complexes.

16. The implantable medical device of claim 14 further comprising means for aligning the test QRS complex with the baseline QRS template.

17. The implantable medical device of claim 14 further comprising means for generating and storing an ischemia burden metric.

18. The implantable medical device of claim 14 further comprising means for adjusting cardiac pacing parameters to increase heart perfusion in response to the detection of ischemia.

19. The implantable medical device of claim 14 further comprising means for determining a current heart rate, wherein the means for generating a baseline QRS template comprises means for generating a baseline QRS template at each of a plurality of heart rates and wherein the means for determining total difference of absolute value of amplitude of a test QRS complex and amplitude of the baseline QRS template at a plurality of sample points comprises means for determining total difference of absolute value of amplitude of a test QRS complex and amplitude of the baseline QRS template corresponding to the current heart rate.

20. The implantable medical device of claim 14 wherein the means for generating a baseline QRS template comprises means for generating a baseline QRS template for each of a plurality of sensing vectors and wherein the means for determining total difference of absolute value of amplitude of a test QRS complex and amplitude of the baseline QRS template at a plurality of sample points comprises means for determining total difference of absolute value of amplitude of a test QRS complex sensed with each of the plurality of sensing vectors with the amplitude of the corresponding baseline QRS template for that sensing vector.

21. The implantable medical device of claim 20 wherein the means for detecting ischemia further comprises means for locating zone of ischemia as a function of each of the plurality of absolute value of difference values.

22. An implantable medical device, comprising:

a pulse generator adapted to deliver a plurality of pacing pulses to a patient'"'"'s heart;

a sensing circuit adapted to sense QRS complexes; and

a microcontroller adapted to determine absolute value of difference between voltage of a test QRS complex and voltage of a baseline QRS template at a plurality of sample points and to detect ischemia if a sum of the differences at the plurality of sample points is greater than an ischemia detection threshold.

23. The implantable medical device of claim 22 wherein the microcontroller is adapted to ensemble average a plurality of digitized baseline QRS complexes to generate the baseline QRS template.

24. The implantable medical device of claim 23 wherein the microcontroller is further adapted to adjust cardiac pacing parameters to increase heart perfusion in response to detection of ischemia.