Wireless systems and methods for the detection of neural events using onboard processing

• US 7,460,904 B2
• Filed: 10/09/2003
• Issued: 12/02/2008
• Est. Priority Date: 10/09/2002
• Status: Active Grant

• Current Assignee: Wake Forest University Health Sciences
• Original Assignee: Wake Forest University Health Sciences
• Inventors: Hampson, Robert E., Deadwyler, Sam A.
• Primary Examiner(s): Marmor, II; Charles A.
• Assistant Examiner(s): Toth; Karen E
• Application Number:
  US10/682,377
• Publication Number:
  US 20040138579A1
• Time in Patent Office: 1,881 Days
• Field of Search: 600/300, 600/544, 607/45
• US Class Current: 600/544
• CPC Class Codes: A61B 5/0002 Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network A61B5/07 takes precedence; transmission systems for measured values G08C; transmission H04B; transmission of digital information H04L; wireless communication networks H04W
• CPC Class Codes: A61B 5/24 Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
• CPC Class Codes: A61B 5/388 Nerve conduction study, e.g. detecting action potential of peripheral nerves

Abstract

A neural event electrode interface is configured to communicate with electrodes that capture electrical signals that are associated with at least one neuron. A neural event waveform processor is configured to extract neural events from the electrical signals. A wireless transmitter is configured to wirelessly transmit the neural events that are extracted from the electrical signals.

Claims

1. A system for detecting neural events comprising:

a neural event electrode interface that is configured to communicate with electrodes that capture electrical signals that are associated with at least one neuron;

a neural event waveform processor that is configured to extract single neuron action potentials with waveforms that exceed 500 Hz from the electrical signals; and

a wireless transmitter that is configured to wirelessly transmit the single neuron action potentials with waveforms that exceed 500 Hz that are extracted from the electrical signals.

2. A system according to claim 1 wherein the neural event waveform processor is configured to extract the single neuron action potentials with waveforms that exceed 500 Hz from the electrical signals by performing time/amplitude window discrimination of the electrical signals.

3. A system according to claim 1 wherein the neural event waveform processor is configured to extract the single neuron action potentials with waveforms that exceed 500 Hz from the electrical signals by applying template matching to the electrical signals.

4. A system according to claim 1 wherein the neural event waveform processor is further configured to time-stamp the single neuron action potentials with waveforms that exceed 500 Hz and wherein the wireless transmitter is configured to wirelessly transmit the single neuron action potentials with waveforms that exceed 500 Hz that are extracted from the electrical signals and associated time-stamps.

5. A system according to claim 1 wherein the neural event waveform processor is further configured to identify a neuron that is responsible for the single neuron action potentials with waveforms that exceed 500 Hz and wherein the wireless transmitter is configured to wirelessly transmit the single neuron action potentials with waveforms that exceed 500 Hz that are extracted from the electrical signals and the associated neuron identification.

6. A system according to claim 1 wherein the neural event waveform processor is configured to extract the single neuron action potentials with waveforms that exceed 500 Hz from the electrical signals by detecting occurrence of single neuron action potentials with waveforms that exceed 500 Hz in the electrical signals and by assigning the single neuron action potentials with waveforms that exceed 500 Hz to a category, and wherein the wireless transmitter is configured to wirelessly transmit the single neuron action potentials with waveforms that exceed 500 Hz that are extracted from the electrical signals by transmitting the category.

7. A system according to claim 1 further comprising a wireless receiver that is configured to wirelessly receive instructions for configuring the neural event waveform processor to use a selected category of algorithms to extract the single neuron action potentials with waveforms that exceed 500 Hz, and to provide the instructions to use the selected category of algorithms to extract the single neuron action potentials with waveforms that exceed 500 Hz to the neural event waveform processor, wherein the neural event waveform processor is configured to use the selected category of algorithms to extract the single neuron action potentials with waveforms that exceed 500 Hz.

10. A system according to claim 1 further comprising a housing, wherein the neural event electrode interface, the neural event waveform processor and the wireless transmitter are contained within and/or on the housing.

11. A system according to claim 10 wherein the housing is about 5 cubic centimeters in volume.

12. A system according to claim 1 wherein the neural event waveform processor comprises:

a plurality of amplifiers that are connected to the neural event electrode interface;

a plurality of analog to digital converters, a respective one of which is responsive to a respective one of the amplifiers; and

a digital signal processor that is responsive to the analog to digital converters;

wherein the wireless transmitter is responsive to the digital signal processor.

13. A system according to claim 1 wherein the electrical signals that are associated with at least one neuron are generated by at least one neuron, a collection of neural tissues, brain regions and/or in vitro brain slices.

14. A system according to claim 1 wherein the electrical signals that are associated with at least one neuron are generated by an in vitro sample.

15. A system according to claim 1 wherein the electrical signals that are associated with at least one neuron are generated by an in vivo subject.

16. A system according to claim 1 wherein the electrical signals that are associated with at least one neuron are generated by at least one neuron, in conjunction with experimentally relevant externally applied stimuli;

in conjunction with genetic manipulation;

before, during and/or after administration of a drug or chemical agent; and

/or in conjunction with a feedback control interface to a prosthesis or other neural interface.

17. A system according to claim 1 further comprising a base station that is configured to wirelessly receive the single neuron action potentials with waveforms that exceed 500 Hz that are transmitted by the wireless transmitter and to further process the single neuron action potentials with waveforms that exceed 500 Hz that are wirelessly received.

18. A system according to claim 17 further comprising a plurality of neural event waveform processors and wireless transmitters, and wherein the base station is configured to wirelessly receive the single neuron action potentials with waveforms that exceed 500 Hz that are transmitted by a plurality of the wireless transmitters and to further process the single neuron action potentials with waveforms that exceed 500 Hz that are wirelessly received.

31. A system according to claim 1 wherein the extracted single neuron action potentials have waveforms that exceed 1000 Hz.

32. A system according to claim 1 wherein the extracted single neuron action potentials have waveforms that exceed 1000 Hz and are less than 10,000 Hz.

33. A system according to claim 1:

wherein the neural event electrode interface is configured to communicate with electrodes that capture electrical signals that are associated with a plurality of neurons; and

wherein the neural event waveform processor is configured to extract a plurality of single neuron action potentials for the plurality of neurons with waveforms that exceed 500 Hz from the electrical signals.

39. A system according to claim 12 further comprising a wireless receiver that is configured to wirelessly receive instructions for configuring the digital signal processor to use a selected category of algorithms to extract the single neuron action potentials with waveforms that exceed 500 Hz, and to provide the instructions to use the selected category of algorithms to extract the single neuron action potentials with waveforms that exceed 500 Hz to the digital signal processor, wherein the digital signal processor is configured to use the selected category of algorithms to extract the single neuron action potentials with waveforms that exceed 500 Hz.

8. A system for detecting neural events comprising:

a neural event electrode interface that is configured to communicate with electrodes that capture electrical signals that are associated with at least one neuron;

a neural event waveform processor that is configured to extract single neuron action potentials with waveforms that exceed 500 Hz from the electrical signals;

a wireless transmitter that is configured to wirelessly transmit the single neuron action potentials with waveforms that exceed 500 Hz that are extracted from the electrical signals; and

a wireless receiver that is configured to wirelessly receive neural stimulation waveforms and to provide the neural stimulation waveforms to the neural event electrode interface, so as to provide the neural stimulation waveforms to the electrodes.

37. A system according to claim 8 wherein the wireless receiver is further configured to wirelessly receive instructions for configuring the neural event waveform processor to use a selected category of algorithms to extract the single neuron action potentials with waveforms that exceed 500 Hz, and to provide the instructions to use the selected category of algorithms to extract the single neuron action potentials with waveforms that exceed 500 Hz to the neural event waveform processor, wherein the neural event waveform processor is configured to use the selected category of algorithms to extract the single neuron action potentials with waveforms that exceed 500 Hz.

9. A system for detecting neural events comprising:

a neural event electrode interface that is configured to communicate with electrodes that capture electrical signals that are associated with at least one neuron;

a neural event waveform processor that is configured to extract single neuron action potentials with waveforms that exceed 500 Hz from the electrical signals; and

a wireless transmitter that is configured to wirelessly transmit the single neuron action potentials with waveforms that exceed 500 Hz that are extracted from the electrical signals;

wherein the neural event waveform processor is further configured to generate neural stimulation waveforms and to provide the neural stimulation waveforms to the neural event electrode interface, so as to provide the neural stimulation waveforms to the electrodes.

38. A system according to claim 9 further comprising a wireless receiver that is configured to wirelessly receive instructions for configuring the neural event waveform processor to use a selected category of algorithms to extract the single neuron action potentials with waveforms that exceed 500 Hz, and to provide the instructions to use the selected category of algorithms to extract the single neuron action potentials with waveforms that exceed 500 Hz to the neural event waveform processor, wherein the neural event waveform processor is configured to use the selected category of algorithms to extract the single neuron action potentials with waveforms that exceed 500 Hz.

19. A method for detecting neural events comprising:

capturing electrical signals that are associated with at least one neuron;

then

extracting single neuron action potentials with waveforms that exceed 500 Hz from the electrical signals; and

then

wirelessly transmitting the single neuron action potentials with waveforms that exceed 500 Hz that are extracted from the electrical signals.

20. A method according to claim 19 wherein extracting comprises performing time/amplitude window discrimination of the electrical signals.

21. A method according to claim 19 wherein extracting comprises applying template matching to the electrical signals.

22. A method according to claim 19 wherein extracting comprises:

detecting occurrence of single neuron action potentials with waveforms that exceed 500 Hz in the electrical signals; and

assigning the single neuron action potentials with waveforms that exceed 500 Hz to a category; and

wherein wirelessly transmitting comprises wirelessly transmitting the assigned category.

23. A method according to claim 19 further comprising wirelessly receiving instructions to use a selected category of algorithms for extracting single neuron action potentials with waveforms that exceed 500 Hz from the electrical signals.

24. A method according to claim 19 further comprising wirelessly receiving neural stimulation waveforms.

25. A method according to claim 19 wherein the at least one neuron comprises a neuron, a collection of neural tissues, brain areas and/or in vitro brain slices.

26. A method according to claim 19 wherein the at least one neuron comprises an in vitro sample.

27. A method according to claim 19 wherein the at least one neuron comprises an in vivo subject.

28. A method according to claim 19 wherein the electrical signals that are associated with at least one neuron are generated by at least one neuron, in conjunction with experimentally relevant externally applied stimuli;

in conjunction with genetic manipulation;

before, during and/or after administration of a drug or chemical agent; and

/or in conjunction with a feedback control interface to a prosthesis or other neural interface.

29. A method according to claim 19 further comprising:

wirelessly receiving the single neuron action potentials with waveforms that exceed 500 Hz that are wirelessly transmitted; and

further processing the single neuron action potentials with waveforms that exceed 500 Hz that are wirelessly received.

34. A method according to claim 19 wherein the extracted single neuron action potentials have waveforms that exceed 1000 Hz.

35. A method according to claim 19 wherein the extracted single neuron action potentials have waveforms that exceed 1000 Hz and are less than 10,000 Hz.

36. A method according to claim 19:

wherein capturing comprises capturing electrical signals that are associated with a plurality of neurons; and

wherein extracting comprises extracting a plurality of single neuron action potentials for the plurality of neurons with waveforms that exceed 500 Hz from the electrical signals.

30. A system for detecting neural events comprising:

means for communicating with electrodes that capture electrical signals that are associated with at least one neuron;

means for extracting single neuron action potentials with waveforms that exceed 500 Hz from the electrical signals; and

means for wirelessly transmitting the single neuron action potentials with waveforms that exceed 500 Hz that are extracted from the electrical signals.