System and method for estimating oxygen concentration in a mixed gas experiencing pressure fluctuations

• US 7,460,959 B2
• Filed: 06/02/2006
• Issued: 12/02/2008
• Est. Priority Date: 06/02/2006
• Status: Active Grant

• Current Assignee: Covidien LP (Medtronic Plc)
• Original Assignee: Nellcor Puritan Bennett LLC (Medtronic Plc)
• Inventors: Jafari, Mehdi Matthew
• Primary Examiner(s): Wachsman; Hal D
• Application Number:
  US11/421,949
• Publication Number:
  US 20070278110A1
• Time in Patent Office: 914 Days
• Field of Search: 702 22- 24, 702/30, 702/32
• US Class Current: 702/24
• CPC Class Codes: A61M 16/0051 with alarm devices
• CPC Class Codes: A61M 16/021 operated by electrical means A61M16/202 – A61M16/205 take precedence
• CPC Class Codes: A61M 16/085 Gas sampling
• CPC Class Codes: A61M 16/12 by mixing different gases
• CPC Class Codes: A61M 2016/1025 the O2 concentration
• CPC Class Codes: G01N 27/404 Cells with anode, cathode and cell electrolyte on the same side of a permeable membrane which separates them from the sample fluid , e.g. Clark-type oxygen sensors
• CPC Class Codes: G01N 33/497 of gaseous biological material, e.g. breath

Abstract

A method for estimating the concentration of a particular gas in a gas mixture having a fluctuating pressure is provided. A sensor output signal indicating the concentration of a particular gas in the gas mixture is received from a gas sensor. The received sensor output signal may vary over time due to the fluctuating pressure of the gas mixture. The received sensor output signal may be processed to determine an estimate of the concentration of the particular gas in the gas mixture. The processing may include performing an autocorrelation of the signal. In some embodiments, the particular gas is oxygen and the method is used to estimate the concentration of oxygen in a gas mixture having a fluctuating pressure.

Claims

1. A method for estimating gas concentration in a gas mixture having a fluctuating pressure, comprising:

receiving from a gas sensor a sensor output signal indicating the concentration of a particular gas in the gas mixture, the received sensor output signal varying over time due to the fluctuating pressure of the gas mixture; and

processing the received sensor output signal to determine an estimate of the concentration of the particular gas in the gas mixture, wherein determining an estimate of the concentration includes determining the square root of a zero difference autocorrelation of the sensor output signal.

2. A method according to claim 1, wherein the particular gas is oxygen and the sensor output signal is received from an oxygen sensor.

3. A method according to claim 2, wherein the sensor output signal is received from a diffusion-limited amperometric oxygen sensor.

4. A method according to claim 2, wherein:

the sensor output signal is received from an oxygen sensor comprising an electrolyte; and

the received sensor output signal corresponds to a quantity of oxygen passing through the electrolyte.

5. A method according to claim 1, wherein the received sensor output signal comprises a current signal representative of the concentration of the particular gas in the gas mixture, the current signal varying over time due to the fluctuating pressure of the gas mixture.

6. A method according to claim 5, wherein the received current signal varies in a cyclostationary manner corresponding to cyclostationary fluctuations of the pressure of the gas mixture.

7. A method according to claim 1, wherein processing the received sensor output signal comprises performing at least one of an analog-to-digital data conversion process and a signal noise filtering process prior to performing the autocorrelation of the sensor output signal.

8. A method according to claim 1, wherein determining an estimate of the concentration of the particular gas in the gas mixture comprises sampling the sensor output signal over a predetermined interval.

9. A method according to claim 1, wherein:

the fluctuating pressure of the gas mixture corresponds to breathing cycles of a patient; and

determining an estimate of the concentration of the particular gas in the gas mixture comprises sampling the sensor output signal over a predetermined number of breathing cycles of the patient.

10. A system for estimating gas concentration in a gas mixture having a fluctuating pressure, comprising:

a gas sensor adapted to interact with the gas mixture and generate a sensor output signal indicating the concentration of a particular gas in the gas mixture, the sensor output signal varying over time due to the fluctuating pressure of the gas mixture;

at least one processor operatively coupled to the gas sensor; and

tangible storage media operatively coupled to the at least one processor, the tangible storage media storing computer-executable instructions for determining an estimate of the concentration of the particular gas in the gas mixture, wherein determining an estimate of the concentration includes determining the square root of a zero difference autocorrelation of the sensor output signal.

11. A system according to claim 10, wherein the particular gas is oxygen and the gas sensor is an oxygen sensor.

12. A system according to claim 11, wherein the oxygen sensor is a diffusion-limited amperometric sensor.

13. A system according to claim 11, wherein:

the oxygen sensor comprises an electrolyte; and

the sensor output signal corresponds to a quantity of oxygen passing through the electrolyte.

14. A system according to claim 10, wherein the sensor output signal comprises a current signal representative of the concentration of the particular gas in the gas mixture, the current signal varying over time due to the fluctuating pressure of the gas mixture.

15. A system according to claim 14, wherein the current signal varies in a cyclostationary manner corresponding to cyclostationary fluctuations of the pressure of the gas mixture.

16. A system according to claim 10, wherein the at least one processor is operable to perform at least one of an analog-to-digital data conversion process and a signal noise filtering process prior to performing the autocorrelation of the sensor output signal.

17. A system according to claim 10, wherein determining an estimate of the concentration of the particular gas in the gas mixture comprises determining a zero difference autocorrelation of the sensor output signal.

18. A system according to claim 10, wherein determining an estimate of the concentration of the particular gas in the gas mixture comprises sampling the sensor output signal over a predetermined interval.

19. A system according to claim 10, wherein:

the fluctuating pressure of the gas mixture corresponds to breathing cycles of a patient; and

determining an estimate of the concentration of the particular gas in the gas mixture comprises sampling the sensor output signal over a predetermined number of breathing cycles of the patient.

20. A tangible computer-readable storage medium including computer-executable instructions for estimating gas concentration in a gas mixture having a fluctuating pressure, comprising:

instructions for receiving from a gas sensor a sensor output signal indicating the concentration of a particular gas in the gas mixture, the received sensor output signal varying over time due to the fluctuating pressure of the gas mixture; and

instructions for processing the received sensor output signal to determine an estimate of the concentration of the particular gas in the gas mixture, wherein determining an estimate of the concentration includes determining the square root of a zero difference autocorrelation of the sensor output signal.

21. A system for estimating gas concentration in a gas mixture having a fluctuating pressure, comprising:

gas sensing means for sensing a gas mixture and generating an output signal indicating the concentration of a particular gas in the gas mixture, the output signal varying over time due to the fluctuating pressure of the gas mixture;

processing means operatively coupled to the gas sensing means; and

tangible storage means for storing instructions that, when executed by the processing means, cause the processing means to determine an estimate of the concentration of the particular gas in the gas mixture, wherein determining an estimate of the concentration includes determining the square root of a zero difference autocorrelation of the output signal generated by the gas sensing means.