Soft contact lenses displaying superior on-eye comfort

• US 7,461,937 B2
• Filed: 01/14/2005
• Issued: 12/09/2008
• Est. Priority Date: 09/10/2001
• Status: Expired due to Term

• Current Assignee: Johnson & Johnson Vision Care Incorporated (Johnson & Johnson)
• Original Assignee: Johnson & Johnson Vision Care Incorporated (Johnson & Johnson)
• Inventors: Turner, David, Young, Kent, Hill, Gregory A., Alli, Azaam, Schnider, Cristina, Steffen, Robert, McCabe, Kevin
• Primary Examiner(s): Stultz; Jessica T
• Application Number:
  US11/036,669
• Publication Number:
  US 20050179862A1
• Time in Patent Office: 1,425 Days
• Field of Search: 351/160.H
• US Class Current: 351/160.00H
• CPC Class Codes: B29D 11/00067 Hydrating contact lenses
• CPC Class Codes: C08F 226/10 N-Vinyl-pyrrolidone

Abstract

The present invention relates to soft contact lenses having an overall comfort preference of at least about 2 to 1 as compared to an Acuvue® contact lens and measured after one week of daily wear. The present invention further relates to a soft contact lens comprising an oxygen transmissibility greater than about 70 barrers/mm and physical properties suitable to provide wearer comfort over at least about 9 hours in at least about 80% of wearers, as measured in a randomized, double masked clinical study.

Claims

1. A soft hydrogel contact lens having a tensile modulus less than about 140 psi, oxygen transmissibility of at least about 70 barrers/mm and a dynamic coefficient of friction of less than about 0.01 when measured at a sliding speed of 10 cm/second, wherein said contact lens comprises at least one lubricious polymer in or on said contact lens, provided however, when said lubricious polymer is coated on said contact lens, said lubricious polymer is not polyacrylic acid or poly(N,N-dimethylacrylamide).

2. The contact lens of claim 1 wherein said oxygen transmissibility is at least about 85 barrers/mm.

3. The contact lens of claim 1 further comprising an advancing dynamic contact angle of less than about 90°

.

4. The lens of claims 1 further comprising a water content of at least about 30%.

5. The lens of claim 1 wherein said oxygen transmissibility is at least about 80 barrers/mm.

6. The lens of claim 2 wherein said oxygen transmissibility is at least about 90 barrers/mm.

7. The lens of claim 1 wherein said oxygen transmissibility is at least about 110 barrers/mm.

8. The lens of claim 1 wherein said oxygen transmissibility is at least about 140 barrers/mm.

9. The lens of claim 3 wherein said advancing dynamic contact angle is less than about 80°

.

10. The lens of claim 3 wherein said advancing dynamic contact angle is less than about 70°

.

11. The lens of claim 4 wherein said water content is between about 30% and about 50%.

12. The lens of claim 6 wherein said lens further comprises a water content between about 30% and about 50%.

13. The lens of claim 1 further comprising a tensile modulus of less than about 120 psi.

14. The lens of claim 1 further comprising a tensile modulus of less than about 100 psi.

15. The lens of claim 1 further comprising a tensile modulus of about 40 to about 100 psi.

16. The lens of claim 2 wherein said lens is formed from a silicone hydrogel.

17. The lens of claim 16 wherein said silicone hydrogel is formed from a reaction mixture comprising at least about 20 weight % silicone containing components.

18. The lens of claim 16 wherein said silicone hydrogel is formed from a reaction mixture comprising between about 20 and about 70 weight % silicone containing components.

19. The lens of claim 17 wherein said reaction mixture comprises at least one monofunctional silicone containing component and less than about 10 mmol multifunctional components/100 g reactive components.

20. The lens of claim 19 wherein said multifunctional components comprise less than about 7 mmol/100 g of the reactive components.

21. The lens of claim 19 wherein said monofunctional silicone containing component is selected from the group consisting of polysiloxanylalkyl(meth)acrylic monomers, mono-functional polydimethylsiloxanes and mixtures thereof.

22. The lens of claim 19 wherein said multifunctional components comprise multifunctional silicone containing components.

23. The lens of claim 22 wherein said multifunctional silicone containing components are selected from the group consisting of poly(organosiloxane) prepolymer, multifunctional silicone-containing vinyl carbonate and vinyl carbamate monomers, polyurethane macromers, and combinations thereof.

24. The lens of claim 17 wherein at least about 30 weight % of said silicone components comprise silicone containing compounds free from branching trimethylsiloxy groups.

25. The lens of claim 17 wherein at least about 60 weight % of said silicone components comprise silicone containing compounds free from branching trimethylsiloxy groups.