Drug delivery particle
First Claim
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1. A drug delivery device comprising:
- a substantially spherical polymer particle comprising polyvinyl alcohol and having a first region including pores having a first predominant pore size and containing therapeutic agent, and a second region substantially surrounding the first region and including pores having a second predominant pore size,wherein the second predominant pore size is from about 50% to about 70% of the first predominant pore size.
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Abstract
A drug delivery particle including a reservoir region having primarily large pores and a metering region. The particle can be highly spherical.
398 Citations
31 Claims
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1. A drug delivery device comprising:
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a substantially spherical polymer particle comprising polyvinyl alcohol and having a first region including pores having a first predominant pore size and containing therapeutic agent, and a second region substantially surrounding the first region and including pores having a second predominant pore size, wherein the second predominant pore size is from about 50% to about 70% of the first predominant pore size. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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12. A method of manufacturing a drug delivery particle, the method comprising:
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generating drops comprising polyvinyl alcohol and alginate; forming the drops into particles; and combining the particles with a therapeutic agent, wherein each of the particles is a substantially spherical polymer particle comprising polyvinyl alcohol and having a first region including pores having a first predominant pore size and containing therapeutic agent, and a second region substantially surrounding the first region and including pores having a second predominant pore size, the second predominant pore size being from about 50% to about 70% of the first predominant pore size. - View Dependent Claims (13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23)
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- 24. A method of delivering a substantially spherical particle to a patient, the method comprising administering to a patient the substantially spherical polymer particle comprising polyvinyl alcohol and having a first region including pores having a first predominant pore size and containing therapeutic agent, and a second region substantially surrounding the first region and including pores having a second predominant pore size, the second predominant pore size being from about 50% to about 70% of the first predominant pore size.
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31. A method of delivering a therapeutic agent to a patient, the method comprising:
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administering to a patient a substantially spherical polymer particle comprising polyvinyl alcohol and having a first region including pores having a first predominant pore size and containing therapeutic agent, and a second region substantially surrounding the first region and including pores having a second predominant pore size, the second predominant pore size being from about 50% to about 70% of the first predominant pore size; and releasing the therapeutic agent in the patient.
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Specification