Tissue mimicking elastography phantoms

• US 7,462,488 B2
• Filed: 05/27/2005
• Issued: 12/09/2008
• Est. Priority Date: 10/04/2002
• Status: Expired due to Term

• Current Assignee: Wisconsin Alumni Research Foundation (University of Wisconsin System)
• Original Assignee: Wisconsin Alumni Research Foundation (University of Wisconsin System)
• Inventors: Frank, Gary R., Madsen, Ernest L.
• Primary Examiner(s): WALLENHORST, MAUREEN
• Application Number:
  US11/140,400
• Publication Number:
  US 20050227364A1
• Time in Patent Office: 1,292 Days
• Field of Search: 436/8, 436/173, 422/102, 73/18.2, 73/18.6, 738/656, 738/664, 252/408.1, 600/437, 600/442
• US Class Current: 436/8
• CPC Class Codes: A61B 5/055 involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
• CPC Class Codes: A61B 8/08 Detecting organic movements or changes, e.g. tumours, cysts, swellings A61B8/02 - A61B8/06 take precedence
• CPC Class Codes: A61B 8/485 involving measuring strain or elastic properties
• CPC Class Codes: A61B 8/587 Calibration phantoms models for medical purposes G09B23/28
• CPC Class Codes: Y10T 436/10 Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
• CPC Class Codes: Y10T 436/24 Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry

Abstract

Tissue mimicking materials for elastography phantoms have elastic, ultrasound, and magnetic resonance characteristics that are characteristic of human soft tissues and well suited for the calibration and performance assessment of elastography imaging systems. In one embodiment, the material is formed from a base material containing an oil dispersed within a gel matrix and at least one inclusion formed from a gel. In another embodiment, the material is formed from a gel-forming material suffused throughout an open-cell reticulated mesh matrix.

Claims

1. An human tumor tissue mimicking material for testing elastography imagers comprising an open-cell reticulated mesh material and a gel-forming material suffused into the mesh material, wherein the Young'"'"'s modulus of the human tumor tissue mimicking material mimics the Young'"'"'s modulus of human tumor tissue.

2. The human tumor tissue mimicking material of claim 1 wherein the Young'"'"'s modulus of the human tumor tissue mimicking material is between about 10 and about 300 kPa.

3. The human tumor tissue mimicking material of claim 1 wherein the open-cell reticulated mesh material is a polyether mesh or a polyurethane mesh.

4. The human tumor tissue mimicking material of claim 1 wherein the open-cell reticulated mesh material comprises between about 10 and about 30 cells per inch.

5. The human tumor tissue mimicking material of claim 1 wherein the gel-forming material comprises gelatin.

6. The human tumor tissue mimicking material of claim 1 wherein the gel-forming material comprises agar.

7. The human tumor tissue mimicking material of claim 1 wherein the material is elastically nonlinear for strains of up to about 10 percent.

8. The human tumor tissue mimicking material of claim 1 wherein the gel-forming material further comprises at least one additional additive selected from the group consisting of a crosslinking agent, an organic hydroxy compound, microscopic solid particles, a copper salt, a chelating agent, and an agent for inhibiting attack by microorganisms.

9. The human tumor tissue mimicking material of claim 1 wherein the gel-forming material comprises an inner volume comprising agar suffused into the mesh material and an outer shell comprising gelatin suffused into the mesh material, wherein the outer shell surrounds the inner volume.

10. The human tumor tissue mimicking material of claim 9 wherein the outer shell comprises a mixture of agar and gelatin.

11. The human tumor tissue mimicking material of claim 10 wherein the inner volume is substantially spherically shaped and the outer shell has a plurality of spicules extending outward away from the inner volume.

12. A human tissue mimicking material for testing elastography imagers, comprising:

(a) a base material comprising a gel-forming material; and

(b) at least one inclusion comprising the human tumor tissue mimicking material claim 1 at least partially surrounded by the base material, wherein the elastic contrast between the base material and the at least one inclusion is such that the elastic contrast between normal soft human tissue and human tumor tissue is mimicked, making the human tissue mimicking material suitable for use in testing elastography imagers.

13. The human tissue mimicking material of claim 12 wherein the elastic contrast between the base material and the at least one inclusion is between about 1 and about 4.

14. The human tissue mimicking material of claim 12 wherein the elastic contrast between the base material and the at least one inclusion is between about 1 and about 3.

15. The human tissue mimicking material of claim 12 wherein the speed of sound in the base material and the at least one inclusion is between about 1300 and 1650 m/s.

16. The human tissue mimicking material of claim 12 wherein the T1 values of the base material and the at least one inclusion are between about 200 ms and about 1200 ms and the T2 values of the base material and the at least one inclusion are between about 40 ms and about 200 ms, and further wherein T1 and T2 refer to hydrogen density and relaxation times.

17. The human tissue mimicking material of claim 12 wherein the elastic contrast between the base material and the at least one inclusion varies by less than about 20% over a period of at least six months.

18. The human tissue mimicking material of claim 12 wherein the gel-forming material in the base material is selected from the group consisting of gelatin, agar, or a mixture of gelatin and agar.

19. An elastography phantom comprising:

(a) an elastography phantom container enclosing an interior space; and

(b) the human tissue mimicking material of claim 12 contained within the interior space of the container.

20. The human tumor tissue mimicking material of claim 1, wherein the open-cell reticulated mesh material is a polyurethane mesh.

21. The human tumor tissue mimicking material of claim 1, wherein the gel-forming material comprises an emulsion of oil-in-gelatin.

22. The human tumor tissue mimicking material of claim 1, wherein the gel- forming material comprises gelatin and agar.

23. The human tumor tissue mimicking material of claim 1, wherein the Young'"'"'s modulus of the human tumor tissue mimicking material is 80 kPa.

24. The human tumor tissue mimicking material of claim 1, wherein the Young'"'"'s modulus of the human tumor tissue mimicking material is 89 kPa.

25. The human tumor tissue mimicking material of claim 1, wherein the Young'"'"'s modulus of the human tumor tissue mimicking material is from about 80 to about 300 kPa.

26. A method for testing an elastography imager comprising, mapping local elastic strains of a human tissue mimicking material to obtain a elastogram of the human tissue mimicking material, the human tissue mimicking material comprising:

(i) a base material comprising a gel-forming material; and

(ii) at least one inclusion of a defined shape at least partially surrounded by the base material, the at least one inclusion comprising an open-cell reticulated mesh material and a gel-forming material suffused into the mesh material, wherein the elastic contrast between the base material and the at least one inclusion is such that the elastic contrast between normal soft human tissue and human tumor tissue is mimicked.

27. The method of claim 26 wherein the elastogram is an ultrasound elastogram or a magnetic resonance elastogram.