Identifying combinations of electrodes for neurostimulation therapy

• US 7,463,928 B2
• Filed: 04/25/2003
• Issued: 12/09/2008
• Est. Priority Date: 04/25/2003
• Status: Active Grant

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Goetz, Steven M., Lee, Michael T., Torgerson, Nathan A.
• Primary Examiner(s): Layno; Carl H.
• Assistant Examiner(s): MORALES, JON ERIC C
• Application Number:
  US10/424,194
• Publication Number:
  US 20040215288A1
• Time in Patent Office: 2,055 Days
• Field of Search: None
• US Class Current: 607/58
• CPC Class Codes: A61N 1/36082 Cognitive or psychiatric applications, e.g. dementia or Alzheimer's disease
• CPC Class Codes: A61N 1/36185 Selection of the electrode configuration
• CPC Class Codes: A61N 1/37247 User interfaces, e.g. input or presentation means
• CPC Class Codes: Y10S 128/903 Radio telemetry

Abstract

A programmer allows a clinician to identify combinations of electrodes from within an electrode set implanted in a patient that enable delivery of desirable neurostimulation therapy by an implantable medical device. The programmer executes an electrode combination search algorithm to select combinations of electrodes to test in a non-random order. According to algorithms consistent with the invention, the programmer may first identify a position of a first cathode for subsequent combinations, and then select electrodes from the set to test with the first cathode as anodes or additional cathodes based on the proximity of the electrodes to the first cathode. The programmer may store information for each combination tested, and the information may facilitate the identification of desirable electrode combinations by the clinician. The clinician may create neurostimulation therapy programs that include identified desirable program combinations.

Claims

1. A method comprising:

selecting a first electrode of a set of electrodes implanted in a patient as a first cathode to include in a combination of electrodes for use in delivery of neurostimulation therapy to the patient;

automatically selecting a sequence of additional electrodes of the set to test with the first cathode as a first anode for inclusion in the combination of electrodes based on decreasing proximity of the additional electrodes to the first cathode; and

controlling an implantable medical device to deliver stimulation via a plurality of combinations of the set of electrodes implanted in the patient, each of the combinations including the first cathode and at least one of the additional electrodes.

2. The method of claim 1, wherein selecting a first electrode comprises receiving input from a user that identifies the first electrode.

3. The method of claim 1, wherein selecting a first electrode comprises:

identifying an initial position within the set;

controlling an implantable medical device to test one of the electrodes located at the initial position for inclusion in the combination as the first cathode; and

controlling the implantable medical device to test additional electrodes of the set for inclusion in the combination as the first cathode in an order determined based on the initial position.

4. The method of claim 3, wherein identifying an initial position within the set comprises:

identifying a configuration of the electrode set; and

identifying the initial position based on the configuration.

5. The method of claim 3, wherein the initial position is a central position within the set, and controlling the implantable medical device to test additional electrodes comprises controlling the implantable medical device to test the additional electrodes in an order based on decreasing proximity of the additional electrodes to the initial position.

6. The method of claim 1, further comprising controlling an implantable medical device to test the additional electrodes according to the sequence.

7. The method of claim 6, wherein controlling an implantable medical device to test the additional electrodes comprises controlling the implantable medical device to test a plurality of combinations of electrodes, each of the combinations including the first cathode and at least one of the additional electrodes.

8. The method of claim 7, wherein controlling the implantable medical device to test a combination of electrodes comprises:

controlling the implantable medical device to deliver neurostimulation via the combination of electrodes;

controlling the implantable medical device to increase an amplitude of the neurostimulation until an indication to stop increasing the amplitude is received from a user;

storing a value of the amplitude at a time when the indication is received from the user as an amplitude value for the combination; and

storing rating information received from the user that describes at least one of the effectiveness of the delivery of neurostimulation at the stored amplitude value in addressing symptoms of the patient and a degree of side effects caused by delivery of neurostimulation at the stored amplitude value as rating information for the combination.

9. The method of claim 8, further comprising:

displaying a list of the tested electrode combinations ordered according to at least one of amplitude values and rating information stored for each of the tested combinations;

receiving a selection of one of the tested combinations made by the user from the list; and

storing information identifying the selected combination as part of a neurostimulation therapy program that defines neurostimulation therapy to be delivered to the patient by the implantable medical device.

10. The method of claim 8, further comprising:

selecting one of the tested combinations based on the information; and

storing information identifying the selected combination as part of a neurostimulation therapy program that defines neurostimulation therapy to be delivered to the patient by the implantable medical device.

11. The method of claim 8, wherein the user is one of a clinician and the patient.

12. The method of claim 6, wherein controlling an implantable device to test the additional electrodes comprises:

identifying a subset of undesignated electrodes within the set based on orientation of the undesignated electrodes with the first cathode and the first anode; and

controlling the implantable medical device to test electrodes within the subset in an order based on decreasing proximity of the electrodes within the subset to the first cathode.

13. The method of claim 1, wherein the combination includes a most recently tested additional electrode, the method further comprising:

identifying untested electrodes that would be tested after the most recently tested additional electrode according to the sequence; and

storing information identifying additional combinations of electrodes that include the identified untested electrodes as part of neurostimulation therapy programs.

14. A computer-readable medium comprising instructions that cause a processor to:

select a first electrode of a set of electrodes implanted in a patient as a first cathode to include in a combination of electrodes for use in delivery of neurostimulation therapy to the patient; and

automatically select a sequence of additional electrodes of the set to test with the first cathode as a first anode for inclusion in the combination of electrodes based on decreasing proximity of the additional electrodes to the first cathode.

15. The computer-readable medium of claim 14, wherein the instructions that cause a processor to select a first electrode comprise instructions that cause a processor to receive input from a user that identifies the first electrode.

16. The computer-readable medium of claim 14, wherein the instructions that cause a processor to select a first electrode comprise instructions that cause a processor to:

identify an initial position within the set;

control an implantable medical device to test one of the electrodes located at the initial position for inclusion in the combination as the first cathode; and

control the implantable medical device to test additional electrodes of the set for inclusion in the combination as the first cathode in an order determined based on the initial position.

17. The computer-readable medium of claim 14, wherein the instructions that cause a processor to identify an initial position within the set comprise instructions that cause a processor to:

identify a configuration of the electrode set; and

identify the initial position based on the configuration.

18. The computer-readable medium of claim 17, wherein the initial position is a central position within the set, and the instructions that cause a processor to control the implantable medical device to test additional electrodes comprise instructions that cause a processor to control the implantable medical device to test the additional electrodes in an order based on decreasing proximity of the additional electrodes to the initial position.

19. The computer-readable medium of claim 14, further comprising instructions that cause a processor to control an implantable medical device to test the additional electrodes according to the sequence.

20. The computer-readable medium of claim 19, wherein the instructions that cause a processor to control an implantable medical device to test the additional electrodes comprise instructions that cause a processor to control the implantable medical device to test a plurality of combinations of electrodes, each of the combinations including the first cathode and at least one of the additional electrodes.

21. The computer-readable medium of claim 20, wherein the instructions that cause a processor to control the implantable medical device to test a combination of electrodes comprise instructions that cause a processor to:

control the implantable medical device to deliver neurostimulation via the combination of electrodes;

control the implantable medical device to increase an amplitude of the neurostimulation until an indication to stop increasing the amplitude is received from a user;

store a value of the amplitude at a time when the indication is received from the user as an amplitude value for the combination; and

store rating information received from the user that describes at least one of the effectiveness of the delivery of neurostimulation at the stored amplitude value in addressing symptoms of the patient and a degree of side effects caused by delivery of neurostimulation at the stored amplitude value as rating information for the combination.

22. The computer-readable medium of claim 21, further comprising instructions that cause a processor to:

display a list of the tested electrode combinations ordered according to at least one of amplitude values and rating information stored for each of the tested combinations;

receive a selection of one of the tested combinations made by the user from the list; and

store information identifying the selected combination as part of a neurostimulation therapy program that defines neurostimulation therapy to be delivered to the patient by the implantable medical device.

23. The computer-readable medium of claim 21, further comprising instructions that cause a processor to:

select one of the tested combinations based on the information; and

store information identifying the selected combination as part of a neurostimulation therapy program that defines neurostimulation therapy to be delivered to the patient by the implantable medical device.

24. The computer-readable medium of claim 21, wherein the user is one of a clinician and the patient.

25. The computer-readable medium of claim 19, wherein the instructions that cause a processor to control an implantable medical device to test the additional electrodes comprise instructions that cause a processor to:

identify a subset of undesignated electrodes within the set based on orientation of the undesignated electrodes with the first cathode and the first anode; and

control the implantable medical device to test electrodes within the subset in an order based on decreasing proximity of the electrodes within the subset to the first cathode.

26. The computer-readable medium of claim 14, wherein the combination includes a most recently tested additional electrode, further comprising instructions that cause a processor to:

identify untested electrodes that would be tested after the most recently tested additional electrode according to the sequence; and

store information identifying additional combinations of electrodes that include the identified untested electrodes as part of neurostimulation therapy programs.

27. A device comprising a processor configured to select a first electrode of a set of electrodes implanted in a patient as a first cathode to include in a combination of electrodes for use in delivery of neurostimulation therapy to the patient, and configured to automatically selects a sequence of additional electrodes of the set to test with the first cathode as a first anode for inclusion in the combination of electrodes based on deceasing proximity of the additional electrodes to the first cathode.

28. The device of claim 27, wherein the processor receives input from a user that identifies the first electrode.

29. The device of claim 27, wherein the processor identifies an initial position within the set, controls the implantable medical device to test one of the electrodes located at the initial position for inclusion in the combination as the first cathode, and controls the implantable medical device to test additional electrodes of the set for inclusion in the combination as the first cathode in an order determined based on the initial position.

30. The device of claim 29, wherein the processor identifies a configuration of the electrode set, and identifies the initial position based on the configuration.

31. The device of claim 29, wherein the initial position is a central position within the set, and the processor controls the implantable medical device to test the additional electrodes in an order based on decreasing proximity of the additional electrodes to the initial position.

32. The device of claim 27, wherein the processor controls an implantable medical device to test the additional electrodes according to the sequence.

33. The device of claim 32, wherein the processor controls the implantable medical device to test a plurality of combinations of electrodes, each combination including the first cathode and at least one additional electrode.

34. The device of claim 33, further comprising a memory, wherein the processor controls the implantable medical device to test a combination of electrodes by controlling the implantable medical device to deliver neurostimulation via the combination of electrodes, controlling the implantable medical device to increase an amplitude of the neurostimulation until an indication to stop increasing the amplitude is received from a user, storing a value of the amplitude at a time when the indication is received from the user as an amplitude value for the combination in the memory, and storing rating information received from the user that describes at least one of the effectiveness of the delivery of neurostimulation at the stored amplitude value in addressing symptoms of the patient and a degree of side effects caused by delivery of neurostimulation at the stored amplitude value in the memory as rating information for the combination.

35. The device of claim 34, wherein the processor displays a list of the tested electrode combinations ordered according to at least one of amplitude values and rating information stored for each of the tested combinations, receives a selection of one of the tested combinations made by the user from the list, and stores information identifying the selected combination as part of a neurostimulation therapy program that defines neurostimulation therapy to be delivered to the patient by the implantable medical device.

36. The device of claim 34, wherein the processor selects one of the tested combinations based on the information, and stores information identifying the selected combination as part of a neurostimulation therapy program that defines neurostimulation therapy to be delivered to the patient by the implantable medical device.

37. The device of claim 32, wherein the processor identifies a subset of undesignated electrodes within the set based on orientation of the undesignated electrodes with the first cathode and the first anode, and controls the implantable medical device to test electrodes within the subset in an order based on decreasing proximity of the electrodes within the subset to the first cathode.

38. The device of claim 27, further comprising a memory, wherein the combination includes a most recently tested additional electrode, and the processor identifies untested electrodes that would be tested after the most recently tested additional electrode according to the order, and stores information identifying additional combinations of electrodes that include the identified untested electrodes as part of neurostimulation therapy programs in the memory.

39. The device of claim 27, wherein the device comprises a programming device associated with one of a clinician and the patient.

40. A method comprising:

selecting a first electrode of a set of electrodes implanted in a patient as a first cathode to include in a combination of electrodes for use in delivery of neurostimulation therapy to the patient;

automatically selecting a sequence of additional electrodes of the set to test with the first cathode as a first anode for inclusion in the combination of electrodes according to locations of the additional electrodes relative to the first cathode; and

controlling an implantable medical device to deliver stimulation via a plurality of combinations of the set of electrodes implanted in the patient, each of the combinations including the first cathode and at least one of the additional electrodes,

wherein selecting a first electrode comprises;

identifying an initial position within the set;

controlling an implantable medical device to test one of the electrodes located at the initial position for inclusion in the combination as the first cathode; and

controlling the implantable medical device to test additional electrodes of the set for inclusion in the combination as the first cathode in an order determined based on the initial position,

wherein the initial position is a central position within the set, and controlling the implantable medical device to test additional electrodes comprises controlling the implantable medical device to test the additional electrodes in an order based on decreasing proximity of the additional electrodes to the initial position.

41. A method comprising:

selecting a first electrode of a set of electrodes implanted in a patient as a first cathode to include in a combination of electrodes for use in delivery of neurostimulation therapy to the patient;

automatically selecting a sequence of additional electrodes of the set to test with the first cathode as a first anode for inclusion in the combination of electrodes according to locations of the additional electrodes relative to the first cathode;

controlling an implantable medical device to deliver stimulation via a plurality of combinations of the set of electrodes implanted in the patient each of the combinations including the first cathode and at least one of the additional electrodes; and

controlling an implantable medical device to test the additional electrodes according to the sequence, wherein controlling the implantable device to test the additional electrodes comprises;

identifying a subset of undesignated electrodes within the set based on orientation of the undesignated electrodes with the first cathode and the first anode; and

controlling the implantable medical device to test electrodes within the subset in an order based on decreasing proximity of the electrodes within the subset to the first cathode.

42. A computer-readable medium comprising instructions that cause a processor to:

select a first electrode of a set of electrodes implanted in a patient as a first cathode to include in a combination of electrodes for use in delivery of neurostimulation therapy to the patient; and

automatically select a sequence of additional electrodes of the set to test with the first cathode as a first anode for inclusion in the combination of electrodes according to locations of the additional electrodes relative to the first cathode,

wherein the instructions that cause a processor to identify an initial position within the set comprise instructions that cause a processor to;

identify a configuration of the electrode set; and

identify the initial position based on the configuration,

wherein the initial position is a central position within the set, and the instructions that cause a processor to control the implantable medical device to test additional electrodes comprise instructions that cause a processor to control the implantable medical device to test the additional electrodes in an order based on decreasing proximity of the additional electrodes to the initial position.

43. A computer-readable medium comprising instructions that cause a processor to:

select a first electrode of a set of electrodes implanted in a patient as a first cathode to include in a combination of electrodes for use in delivery of neurostimulation therapy to the patient;

automatically select a sequence of additional electrodes of the set to test with the first cathode as a first anode for inclusion in the combination of electrodes according to locations of the additional electrodes relative to the first cathode; and

control an implantable medical device to test the additional electrodes according to the sequence, wherein the instructions that cause a processor to control an implantable medical device to test the additional electrodes comprise instructions that cause a processor to;

identify a subset of undesignated electrodes within the set based on orientation of the undesignated electrodes with the first cathode and the first anode; and

control the implantable medical device to test electrodes within the subset in an order based on decreasing proximity of the electrodes within the subset to the first cathode.

44. A device comprising a processor configured to select a first electrode of a set of electrodes implanted in a patient as a first cathode to include in a combination of electrodes for use in delivery of neurostimulation therapy to the patient, and automatically selects a sequence of additional electrodes of the set to test with the first cathode as a first anode for inclusion in the combination of electrodes according to locations of the additional electrodes relative to the first cathode,

wherein the processor configured to identify an initial position within the set, controls the implantable medical device to test one of the electrodes located at the initial position for inclusion in the combination as the first cathode, and Controls the implantable medical device to test additional electrodes of the set for inclusion in the combination as the first cathode in an order determined based on the initial position, and

wherein the initial position is a central position within the set, and the processor controls the implantable medical device to test the additional electrodes in an order based on decreasing proximity of the additional electrodes to the initial position.

45. A device comprising a processor configured to select a first electrode of a set of electrodes implanted in a patient as a first cathode to include in a combination of electrodes for use in delivery of neurostimulation therapy to the patient, and automatically selects a sequence of additional electrodes of the set to test with the first cathode as a first anode for inclusion in the combination of electrodes according to locations Of the additional electrodes relative to the first cathode,

wherein the processor configured to control an implantable medical device to test the additional electrodes according to the sequence, and

wherein the processor configured to identify a subset of undesignated electrodes within the set based on orientation of the undesignated electrodes with the first cathode and the first anode, and controls the implantable medical device to test electrodes within the subset in an order based on decreasing proximity of the electrodes within the subset to the first cathode.