Unit dose cartridge and dry powder inhaler
First Claim
1. A medicament-dispensing inhaler comprising, in combination, a mouthpiece adapted to deliver airborne medicament to a patient'"'"'s upper respiratory tract at a position away from the patient'"'"'s mouth front and upper oropharyngeal region, and a housing, the housing having a mixing cavity adapted to selectively mount a medicament-containing cartridge;
- and an air-flow cavity for assisting in the delivery of air into and through a cartridge in the mixing cavity and into and through the mouthpiece, further including a cartridge comprising a first element defining an air inlet hole and an air outlet hole, and a second element, the second element snugly fitted into the first element so as to define, with the first element, a medicament-containing cavity, the second element also defining an air inlet hole and an air outlet hole, the first element and the second element being movable with respect to one another so as to place the air inlet holes in the first element and the second element in registry with one another and to simultaneously place the air outlet holes in the first element and the second element in registry with one another so as to permit a flow of air into, through, and out of the cartridge, the first element and the second element being movable with respect to one another so as to reconfigure the first and second elements thereby placing the inlet and outlet holes out of registry with one another and thereby prohibiting air flow through the cartridge and securely retaining medicament within the cartridge.
9 Assignments
0 Petitions
Accused Products
Abstract
A dry powder inhaler having improved aerodynamic properties for diluting, dispersing, and metering drug particles for increasing the efficiency of pulmonary drug delivery to a patient is described. The inhaler comprises, in general, a housing having an air intake, an air flow-control/check-valve, a mixing section and a mouthpiece. A cartridge loaded with a single dose of medicament can be installed in the mixing section.
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Citations
36 Claims
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1. A medicament-dispensing inhaler comprising, in combination, a mouthpiece adapted to deliver airborne medicament to a patient'"'"'s upper respiratory tract at a position away from the patient'"'"'s mouth front and upper oropharyngeal region, and a housing, the housing having a mixing cavity adapted to selectively mount a medicament-containing cartridge;
- and an air-flow cavity for assisting in the delivery of air into and through a cartridge in the mixing cavity and into and through the mouthpiece, further including a cartridge comprising a first element defining an air inlet hole and an air outlet hole, and a second element, the second element snugly fitted into the first element so as to define, with the first element, a medicament-containing cavity, the second element also defining an air inlet hole and an air outlet hole, the first element and the second element being movable with respect to one another so as to place the air inlet holes in the first element and the second element in registry with one another and to simultaneously place the air outlet holes in the first element and the second element in registry with one another so as to permit a flow of air into, through, and out of the cartridge, the first element and the second element being movable with respect to one another so as to reconfigure the first and second elements thereby placing the inlet and outlet holes out of registry with one another and thereby prohibiting air flow through the cartridge and securely retaining medicament within the cartridge.
- View Dependent Claims (2, 3, 4, 5, 6, 7, 13, 20, 21, 22, 23)
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8. A medicament-dispensing inhaler, comprising, in combination, a mouthpiece adapted to deliver airborne medicament to a patient'"'"'s upper respiratory tract at a position away from the patient'"'"'s mouth front and upper oropharyngeal region, and a housing, the housing having a mixing cavity adapted to selectively mount a medicament-containing cartridge;
- and an air-flow cavity for assisting in the delivery of air into and through a cartridge in the mixing cavity and into and through the mouthpiece, and a cartridge mounted within the mixing cavity, the cartridge comprising a first element defining and air inlet hole and an air outlet hole, a second element snugly fitted to the first element so as to define, with the first element, a medicament-containing cavity, the second element further defining and air inlet hole and air outlet hole, the first element and the second element being movable with respect to one another so as to place the air inlet holes in the first element and the second element in registry with one another and to simultaneously place the air outlet holes in the first element and the second element in registry with one another so as to permit a flow of air into, through and out of the cartridge;
the first element and the second element being movable with respect to one another so as to reconfigure the first and second elements to thereby place the element inlet and outlet holes out of registry with one another and thereby prohibit air flow through the cartridge and securely retain medicament within the cartridge. - View Dependent Claims (9, 10, 11)
- and an air-flow cavity for assisting in the delivery of air into and through a cartridge in the mixing cavity and into and through the mouthpiece, and a cartridge mounted within the mixing cavity, the cartridge comprising a first element defining and air inlet hole and an air outlet hole, a second element snugly fitted to the first element so as to define, with the first element, a medicament-containing cavity, the second element further defining and air inlet hole and air outlet hole, the first element and the second element being movable with respect to one another so as to place the air inlet holes in the first element and the second element in registry with one another and to simultaneously place the air outlet holes in the first element and the second element in registry with one another so as to permit a flow of air into, through and out of the cartridge;
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12. A medicament-dispensing inhaler, comprising, in combination a mouthpiece adapted to deliver airborne medicament to a patient'"'"'s upper respiratory tract at a position away from the patient'"'"'s mouth front and upper oropharyngeal region, and a housing, the housing having a mixing cavity adapted to selectively mount a medicament-containing cartridge and air-flow cavity for assisting in the delivery of air into and through a cartridge in the mixing cavity and into and through the mouthpiece, and a cartridge mounted within the mixing cavity, the cartridge comprising a hollow first element defining an air inlet hole and an air outlet hole, a hollow second element snugly fitted to the first element so as to define, with the first element, a medicament-containing cavity, the second element further defining an air inlet hole and an air outlet hole, the first element and the second element being twistable with respect to one another so as to place the air inlet holes in the first element and the second element in registry with one another and to simultaneously place the air outlet holes in the first element and the second element in registry with one another so as to permit a flow of air into, through, and out of the cartridge;
- the first element and the second element being movable with respect to one another so as to reconfigure the first and second elements to thereby place the element inlet and outlet holes out of registry with one another and thereby prohibit air flow through the cartridge and securely retain medicament within the cartridge, the inhaler further comprising a swivel mechanism for twisting the mouthpiece between a storage position, a cartridge insertion and removal position, and a use position; and
for simultaneously twisting the cartridge first and second elements between an air-flow-permitting configuration and a medicament-retaining configuration.
- the first element and the second element being movable with respect to one another so as to reconfigure the first and second elements to thereby place the element inlet and outlet holes out of registry with one another and thereby prohibit air flow through the cartridge and securely retain medicament within the cartridge, the inhaler further comprising a swivel mechanism for twisting the mouthpiece between a storage position, a cartridge insertion and removal position, and a use position; and
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14. A medicament-dispensing inhaler comprising, in combination, a mouthpiece adapted to deliver airborne medicament to a patient'"'"'s upper respiratory tract at a position away from the patient'"'"'s mouth front and upper oropharyngeal region, and a housing, the housing having a mixing cavity adapted to selectively mount a medicament-containing cartridge;
- and an air-flow cavity for assisting in the delivery of air into and through a cartridge in the mixing cavity and into and through the mouthpiece, further including an air-flow controlling check valve mechanism adapted to be mounted within the housing air-flow cavity for assisting in the delivery of an air-flow of predetermined velocity and volume into and through the cartridge and mouthpiece wherein said air-flow controlling check valve mechanism includes an air passage bore of extended length for straightening air-flow, a bulb reciprocable in said bore, and biasing means urging said bulb out of an air-flow inhibiting position.
- View Dependent Claims (15, 16, 17, 18, 19)
- 24. An air-flow controlling check valve mechanism adapted to be mounted within a housing air-flow cavity of an inhaler for assisting in the delivery of an air-flow of predetermined velocity and volume into and through an inhaler cartridge and mouthpiece wherein said check valve mechanism includes an air passage bore of extended length for straightening air-flow, a bulb reciprocable in said bore, and a venturi communicating with said bore.
- 30. A method of using an inhaler to deliver a pre-determined amount of medicament to an inhaler user, comprising the steps of installing a cartridge containing the predetermined amount of medicament in the inhaler, configuring the cartridge for medicament delivery by configuring the inhaler for use, and drawing a predetermined volume of air at a predetermined rate through the inhaler so as to aerosolize substantially all the medicament in the cartridge and deliver the aerosolized medicament to the user wherein said cartridge comprises at least two cartridge elements, and wherein the step of configuring the cartridge for medicament delivery comprises the step of twisting the cartridge elements relative to one another.
- 32. A medicament-dispensing inhaler comprising, in combination, a mouthpiece adapted to deliver airborne medicament to a patient'"'"'s upper respiratory tract at a position away from the patient'"'"'s mouth front and upper oropharyngeal region, and a housing, the housing having a mixing cavity adapted to encourage a flow of air to mix with, deagglomerate and transport medicament to and through the mouthpiece wherein the inhaler includes a venturi for the regulation of proper volumetric aerosolizing air-flow through the cartridge and bypass-air-flow around the cartridge.
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35. A medicament-dispensing inhaler, comprising, in combination, a mouthpiece adapted to deliver airborne medicament to a patient'"'"'s upper respiratory tract at a position away from the patient'"'"'s mouth front and upper oropharyngeal region, and a housing, the housing having a mixing cavity including a cartridge-mounting mechanism to selectively mount a medicament-containing cartridge;
- the cartridge-mounting mechanism having keying structure adapted to mate uniquely with cartridge keying structures so as to permit only preselected cartridge to be mounted in and used with the inhaler wherein said cartridge-mounting mechanism includes a cap movable between an open position for mounting and de-mounting the cartridge, and a closed position permitting the inhaler to be used.
- View Dependent Claims (36)
Specification