Catheter system for intracranial treatment

• US 7,465,292 B2
• Filed: 10/28/2005
• Issued: 12/16/2008
• Est. Priority Date: 04/25/2003
• Status: Expired due to Term

• Current Assignee: AD-Tech Medical Instrument Corp.
• Original Assignee: AD-Tech Medical Instrument Corp.
• Inventors: Putz, David A.
• Primary Examiner(s): Lucchesi; Nicholas D
• Assistant Examiner(s): Stigell; Theodore J
• Application Number:
  US11/262,376
• Publication Number:
  US 20060079857A1
• Time in Patent Office: 1,145 Days
• Field of Search: 604/171, 604/173, 604/272, 604/93.01, 604/158, 60416401-16411, 60417001-17002, 604/167.01, 604/167.02, 604/167.06
• US Class Current: 604/164.09
• CPC Class Codes: A61B 5/031 Intracranial pressure
• CPC Class Codes: A61B 5/1473 invasive, e.g. introduced into the body by a catheter A61B5/1482 takes precedence
• CPC Class Codes: A61B 5/24 Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
• CPC Class Codes: A61B 5/4094 Diagnosing or monitoring seizure diseases, e.g. epilepsy
• CPC Class Codes: A61B 5/6852 Catheters
• CPC Class Codes: A61M 2025/105 having a balloon suitable for drug delivery, e.g. by using holes for delivery, drug coating or membranes
• CPC Class Codes: A61M 2025/1052 for temporarily occluding a vessel for isolating a sector
• CPC Class Codes: A61M 2210/0693 Brain, cerebrum
• CPC Class Codes: A61M 25/007 Side holes, e.g. their profiles or arrangements; Provisions to keep side holes unblocked
• CPC Class Codes: A61M 25/0662 Guide tubes
• CPC Class Codes: A61M 25/10 Balloon catheters A61M25/0125 takes precedence; embolectomy A61B17/22032; retractors A61B17/02; inflatable balloons for placing stents or stent-grafts A61F2/958 ; stomach balloons for treatment of obesity A61F5/0003; oesophagal tubes A61J15/00

Abstract

A catheter system is provided having an outer catheter and at least one inner catheter chosen from a plurality of different inner catheters for delivery of a treatment agent to a selected tissue region of the brain. The outer catheter has a lumen in communication with an opening and at least one aperture. Each inner catheter is sized to be received within the lumen and has a passageway and at least one port in communication with that passageway. The system preferably has inner catheters having different lengths and/or passageways with different diameters. The outer catheter can include an element that monitors brain activity. The outer catheter can also have an inflatable balloon proximal to an element. A method of delivering a treatment agent, preferably a drug, to a select tissue region of a targeted area of the brain for intracranial treatment of a patient is also disclosed.

Claims

1. A catheter system for intracranial treatment of a patient comprising:

an outer catheter having an opening, at least one open aperture at a distal end, and a lumen in communication with respect to the opening and the aperture, the aperture being coaxial with the lumen and the outer catheter being adapted for insertion into the brain of the patient; and

at least first and second inner catheters chosen from a plurality of different inner catheters for delivering a treatment agent to a select tissue region of the patient'"'"'s brain, each inner catheter having a substantially identical outer diameter so that each inner catheter is adapted to be individually received within the lumen, the lumen snugly receiving each inner catheter and guiding each inner catheter to the tissue region, each inner catheter being adapted to extend through the aperture when inserted into the lumen and having a passageway and at least one port in communication with the passageway, the first inner catheter having a first length for delivering the treatment agent to a first tissue region and the second inner catheter having a second length for delivering the treatment agent to a second tissue region.

2. The catheter system of claim 1 wherein the second length is greater than the first length such tat the second tissue region is at a greater distance distal from the aperture than the first tissue region.

3. The catheter system of claim 1 wherein each inner catheter has a distal end and the port on each inner catheter is positioned at the distal end.

4. The catheter system of claim 1 wherein each inner catheter has a different arrangement of a plurality of ports.

5. The catheter system of claim 1 wherein the treatment agent is a fluid.

6. The catheter system of claim 5 wherein the fluid is a drug.

7. The catheter system of claim 5 wherein the passageway of the first inner catheter has a first diameter and the passageway of the second inner catheter has a second diameter, the second diameter being greater than the first diameter such that the delivery of the fluid to the second tissue region is at a different flow rate than the delivery of the fluid to the first tissue region.

8. The catheter system of claim 1 wherein the at least one aperture is a first aperture, the outer catheter further includes a second aperture, and the outer catheter has an axis and an exterior, the second aperture being spaced apart axially from the first aperture along the exterior.

9. The catheter system of claim 8 wherein the outer catheter further includes a third aperture, the second and third apertures being spaced radially about the axis along the exterior.

10. The catheter system of claim 1 wherein the outer catheter includes an element adapted to monitor brain activity within the tissue region, to electronically stimulate the tissue region, or to provide information on a precise position of the element when the element is located entirely within the brain.

11. The catheter system of claim 10 wherein the brain activity being monitored is electrical activity.

12. The catheter system of claim 10 wherein the element is a micro-contact.

13. The catheter system of claim 10 wherein the element is a sensor.

14. The catheter system of claim 13 wherein the sensor senses chemical activity.

15. The catheter system of claim 10 wherein the element is a location marker to identify the position of the outer catheter within the brain.

16. The catheter system of claim 10 wherein the element is mounted proximal to a distal end of the outer catheter upon an exterior surface of a distal portion of the outer catheter.

17. The catheter system of claim 1 wherein the outer catheter further includes a proximal portion, an exterior, and a conduit extending from the proximal portion to an inflatable balloon secured to the exterior.

18. The catheter system of claim 17 wherein the balloon is inflatable with at least one drug and the balloon is formed from a material permeable to the drug such that the drug can be introduced into the brain through the balloon.

19. The catheter system of claim 17 wherein the balloon is positioned along the outer catheter proximally adjacent to the aperture, the balloon being adapted to seal upon inflation a tract created upon insertion of the outer catheter into the brain.

20. The catheter system of claim 17 wherein the balloon is positioned along the outer catheter proximal to at least one element.

21. The catheter system of claim 1 wherein the outer catheter has a proximal end and the opening is positioned at the proximal end.

22. The catheter system of claim 21 wherein the outer catheter has a tapered fitting at the proximal end, the tapered fitting being configured for removable engagement to a fitting at a proximal end of each inner catheter.

23. The catheter system of claim 22 wherein the tapered fitting on the outer catheter is snugly received within the fitting on each inner catheter.

24. The catheter system of claim 21 wherein the proximal end abuts a threaded exterior portion such that the outer catheter may be screwed into the skull of the patient after the outer catheter is placed in a targeted area within the patient'"'"'s brain.

25. The catheter system of claim 24 wherein the first inner catheter is threadably received by the outer catheter to firmly secure the inner catheter to the outer catheter.

26. The catheter system of claim 1 wherein the outer catheter has a diameter between about 0.6 millimeters and 3.0 millimeters.

27. The catheter system of claim 26 wherein the diameter is about 1.0 millimeters.