Apparatus, system, and method of detecting an analyte utilizing pyroelectric technology

• US 7,465,427 B2
• Filed: 04/12/2006
• Issued: 12/16/2008
• Est. Priority Date: 01/29/2004
• Status: Expired due to Fees

• Current Assignee: Nextteq, LLC
• Original Assignee: Bryan Truex, Charles Loomis
• Inventors: Truex, Bryan, Loomis, Charles
• Primary Examiner(s): Jung; Unsu
• Application Number:
  US11/403,219
• Publication Number:
  US 20070048789A1
• Time in Patent Office: 979 Days
• Field of Search: 436/147, 422/82.01, 422/82.02, 422/82.05, 422/82.12
• US Class Current: 422/82.05
• CPC Class Codes: G01N 25/482 concerning the temperature responsive elements measuring temperature or quantity of heat, thermally-sensitive elements G01K; thermoelectric devices H10N10/00, H10N15/00

Abstract

A system for the measurement of a target analyte is provided including a detection apparatus and a reading apparatus. The detection apparatus, or “carrier”, includes a pyroelectric transducer (“pyroelectric film”) and one or more reagent concentrations (“reagent deposit”) deposited on the film. The reagent deposits are adapted to react with, and thus, detect the presence of a target analyte present in the local environment. Upon detection of the target analyte by the reagent deposit, the reading apparatus and the pyroelectric film may be used to detect the amount of heat that can be absorbed by the reagent deposit in response to irradiation. The pyroelectric film then delivers to the reader a signal corresponding to heat detected and the reader provides a corresponding indication of the concentration of the target substance detected.

Claims

1. A system for detecting a target analyte comprising:

a transparent substrate having a first surface, a second surface disposed opposite said first surface and a reagent deposit supported on at least one of said first and second surfaces, said reagent deposit being reactive to exposure to the target analyte to change a capacity of the reagent deposit to absorb electromagnetic energy;

a means for moving a sample of a local environment across the transparent substrate to cause a change in the capacity of the reagent deposit to absorb electromagnetic energy when the sample of the local environment includes the target analyte a piezoelectric transducer positioned adjacent to and spaced apart from the transparent substrate;

a piezoelectric reader that emits a light onto said reagent deposit and measures a change in the capacity of the reagent deposit to absorb electromagnetic energy;

an indicator coupled to the piezoelectric reader that indicates detection of the target analyte; and

a control mechanism for controlling the means for moving the sample of the local environment across the transparent substrate.

2. The system of claim 1 wherein:

the indicator consisting of one or more selected from a digital display, a visual alarm, an audible alarm and a vibrating alarm.

3. The system of claim 1 wherein said means for moving the sample of the local environment comprises a pump.

4. The system of claim 3 further comprising:

a flow regulator for controlling an amount of the sample of the local environment moved across the transparent substrate; and

,

a flow meter for measuring the amount of the sample of the local environment moved across the transparent substrate.

5. The system of claim 1 further comprising a filter coupled to said means for moving a sample of the the local environment.

6. The system of claim 1 further comprising one or more environmental sensors selected from a group consisting of a temperature sensor, a pressure sensor and a humidity sensor.

7. The system of claim 1 wherein said transparent substrate comprises a cartridge including multiple reagents that tests for at least one target analyte.

8. The system of claim 1, further comprising an electromagnetic (EM) source that generates energy in the microwave frequency spectrum.

9. The system of claim 1 wherein the piezoelectric reader contains a timer.

10. The system of claim 3 further comprising a flow control of the pump, wherein the flow control of the pump is comprised of an orifice arranged in a flow path of the sample of the local environment.

11. The system of claim 1 further comprising a pump including a motor having a flow control that is controlled by a speed of the motor.

12. The system of claim of 3 wherein a reading from the piezoelectric reader is used as a baseline and subtracted from subsequent readings such that a non-reversible reagent becomes reusable for multiple readings.

13. The system of claim 4 further comprising a memory wherein a maximum point of exposure relating to saturation of the reagent is pre-stored in the memory.

14. The system of claim 1 wherein the reagent is reversible and reusable.

15. The system of claim 1 wherein the reagent is non-reversible and reusable.

16. The system of claim 1 wherein the reagent is printed onto the substrate using an inkjet printer.

17. The system of claim 1 wherein the reagent is screen printed onto the substrate.

18. The system of claim 1 wherein the reagent includes a top, bottom and sides, said reagent being cast in a mold onto the substrate such that the molded reagent is symmetrical on the top, bottom and sides.

19. The system of claim 1 wherein the light source is located on a removable assembly subcomponent of the system.

20. The system of claim 1 further comprising a filter assembly that is located on a removable assembly subcomponent of the system.

21. The system of claim 1 wherein said transparent substrate contains a memory chip.