Methods for treating eye disorders

• US 7,465,458 B2
• Filed: 04/19/2007
• Issued: 12/16/2008
• Est. Priority Date: 05/20/2003
• Status: Expired due to Fees

• Current Assignee: Allergan, Inc. (Canada) (Abbvie Incorporated)
• Original Assignee: Allergan, Inc. (Canada) (Abbvie Incorporated)
• Inventors: First, Eric R.
• Primary Examiner(s): Navarro; Mark
• Assistant Examiner(s): PORTNER, VIRGINIA ALLEN
• Application Number:
  US11/737,641
• Publication Number:
  US 20080199498A1
• Time in Patent Office: 607 Days
• Field of Search: None
• US Class Current: 424/247.1
• CPC Class Codes: A61K 38/4893 Botulinum neurotoxin (3.4.24.69)
• CPC Class Codes: A61P 27/02 Ophthalmic agents
• CPC Class Codes: A61P 29/00 Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
• CPC Class Codes: A61P 31/04 Antibacterial agents
• CPC Class Codes: A61P 31/10 Antimycotics
• CPC Class Codes: A61P 31/12 Antivirals
• CPC Class Codes: A61P 37/02 Immunomodulators

Abstract

The present invention provides methods of treating an eye disorder. The methods comprise a step of locally administering a Clostridial toxin to the eye of a patient to treat the disorder. The eye disorder may be associated with an inflammation of the eye, including for example, bacterial conjunctivitis, fungal conjunctivitis, viral conjunctivitis, uveitis, keratic precipitates, macular edema, and inflammation response after intra-ocular lens implantation. The Clostridial toxin may be produced by a Clostridial beratti, a Clostridia butyricum, a Clostridial tetani bacterium and/or a Clostridial botulinum.

Claims

1. A method for treating an eye disorder, comprising:

administering to an eye of a mammal an ophthalmic composition, wherein the ophthalmic composition is a solution and contains an ophthalmically acceptable carrier, a Clostridial toxin in an amount effective to treat the eye disorder when the composition is administered to an eye, a polyanionic component in amount effective to provide lubrication to the eye and a vasoconstrictor comprises from about 0.001% (w/v) to about 0.5% (w/v) of the composition, thereby treating the eye disorder.

2. The method of claim 1, wherein Clostridial toxin is a botulinum toxin selected from the group consisting of botulinum toxin types A, B, C₁, D, E, F, G and mixtures thereof.

3. The method of claim 1, wherein the Clostridial toxin is botulinum toxin type A.

4. The method of claim 1, wherein the eye disorder is conjunctivitis.

5. The method of claim 1, wherein the eye disorder is bacterial conjunctivitis, fungal conjunctivitis, viral conjunctivitis, uveitis, keratic precipitates, macular edema, and inflammation response after intra-ocular lens implantation.

6. A method for treating an eye disorder, comprising:

administering to an eye of a mammal an ophthalmic composition, wherein the ophthalmic composition is a solution and contains an ophthalmically acceptable carrier, a Clostridial toxin in an amount effective to treat the eye disorder when the composition is administered to an eye, a polyanionic component comprising from about 0.05% (w/v) to about 5% (w/v) of the composition, and a vasoconstrictor, thereby treating the eye disorder.

7. The method of claim 6, wherein Clostridial toxin is a botulinum toxin selected from the group consisting of botulinum toxin types A, B, C₁, D, E, F, G and mixtures thereof.

8. The method of claim 6, wherein the Clostridial toxin is botulinum toxin type A.

9. The method of claim 7, wherein the eye disorder is selected from the group consisting of bacterial conjunctivitis, fungal conjunctivitis, viral conjunctivitis, uveitis, keratic precipitates, macular edema, or inflammation response after intra-ocular lens implantation.

10. The method of claim 7, wherein the ophthalmic composition further comprises a suitable tonicity adjusting component.

11. The method of claim 10, wherein the suitable tonicity adjusting component is selected from the group consisting of sodium borate, boric acid, sodium chloride, potassium chloride, mannitol, dextrose, glycerin, propylene glycol and mixtures thereof.