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Early detection of sepsis

  • US 7,465,555 B2
  • Filed: 03/26/2003
  • Issued: 12/16/2008
  • Est. Priority Date: 04/02/2002
  • Status: Active Grant
First Claim
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1. A method of detecting early sepsis in a patient, wherein said method comprising the steps of:

  • a) monitoring expression of markers comprising neutrophil-associated CD11b, neutrophil-associated CD64, and monocyte-associated HLA-DR over a period of time;

    b) independently deriving marker statistics comprising a maximum of said neutrophil-associated CD11b expression, a maximum of said neutrophil-associated CD64 expression, and minimum of said monocyte-associated HLA-DR expression; and

    c) applying a decision rule to the marker statistics from step (b) to detect early sepsis in said patient;

    wherein said decision rule is a classification tree that detects early sepsis ifa sum of said maximum of said neutrophil-associated CD11b expression and said maximum of said neutrophil-associated CD64 expression is greater than a first threshold value, and said minimum of said monocyte-associated HLA-DR expression is less than a second threshold value;

    or said decision rule is a classification tree that detects early sepsis ifa sum of said maximum of said neutrophil-associated CD11b expression and said maximum of said neutrophil-associated CD64 expression is greater than a third threshold value, and said maximum of said neutrophil-associated CD64 expression is greater than a fourth threshold value;

    ora sum of said maximum of said neutrophil-associated CD11b expression and said maximum of said neutrophil-associated CD64 expression is less than said third threshold value, and said minimum of said monocyte-associated HLA-DR expression is less than a fifth threshold value.

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