Early detection of sepsis
First Claim
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1. A method of detecting early sepsis in a patient, wherein said method comprising the steps of:
- a) monitoring expression of markers comprising neutrophil-associated CD11b, neutrophil-associated CD64, and monocyte-associated HLA-DR over a period of time;
b) independently deriving marker statistics comprising a maximum of said neutrophil-associated CD11b expression, a maximum of said neutrophil-associated CD64 expression, and minimum of said monocyte-associated HLA-DR expression; and
c) applying a decision rule to the marker statistics from step (b) to detect early sepsis in said patient;
wherein said decision rule is a classification tree that detects early sepsis ifa sum of said maximum of said neutrophil-associated CD11b expression and said maximum of said neutrophil-associated CD64 expression is greater than a first threshold value, and said minimum of said monocyte-associated HLA-DR expression is less than a second threshold value;
or said decision rule is a classification tree that detects early sepsis ifa sum of said maximum of said neutrophil-associated CD11b expression and said maximum of said neutrophil-associated CD64 expression is greater than a third threshold value, and said maximum of said neutrophil-associated CD64 expression is greater than a fourth threshold value;
ora sum of said maximum of said neutrophil-associated CD11b expression and said maximum of said neutrophil-associated CD64 expression is less than said third threshold value, and said minimum of said monocyte-associated HLA-DR expression is less than a fifth threshold value.
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Abstract
Diagnostic methods, systems, and kits for identifying patients with systemic inflammatory response syndrome who are likely to progress to sepsis.
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Citations
3 Claims
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1. A method of detecting early sepsis in a patient, wherein said method comprising the steps of:
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a) monitoring expression of markers comprising neutrophil-associated CD11b, neutrophil-associated CD64, and monocyte-associated HLA-DR over a period of time; b) independently deriving marker statistics comprising a maximum of said neutrophil-associated CD11b expression, a maximum of said neutrophil-associated CD64 expression, and minimum of said monocyte-associated HLA-DR expression; and c) applying a decision rule to the marker statistics from step (b) to detect early sepsis in said patient; wherein said decision rule is a classification tree that detects early sepsis if a sum of said maximum of said neutrophil-associated CD11b expression and said maximum of said neutrophil-associated CD64 expression is greater than a first threshold value, and said minimum of said monocyte-associated HLA-DR expression is less than a second threshold value;
or said decision rule is a classification tree that detects early sepsis ifa sum of said maximum of said neutrophil-associated CD11b expression and said maximum of said neutrophil-associated CD64 expression is greater than a third threshold value, and said maximum of said neutrophil-associated CD64 expression is greater than a fourth threshold value;
ora sum of said maximum of said neutrophil-associated CD11b expression and said maximum of said neutrophil-associated CD64 expression is less than said third threshold value, and said minimum of said monocyte-associated HLA-DR expression is less than a fifth threshold value. - View Dependent Claims (2, 3)
the sum of said maximum of said neutrophil-associated CD11b expression and said maximum of said neutrophil-associated CD64 expression is less than the third threshold value, and said minimum of said monocyte-associated HLA-DR expression is less than the fifth threshold value.
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Specification