Oral detection test for cannabinoid use
First Claim
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1. A method for confirming the active intake of marijuana in a test subject comprising the steps of:
- obtaining a test sample of oral fluid from said test subject; and
detecting the amount of 11-nor-Δ
9 THC carboxylic acid (“
THCA”
) in said test sample,wherein said THCA has not been externally added to said test sample and said amount of THCA is less than about 240 pg/ml but greater than a predetermined cutoff amount;
wherein the presence of THCA in said test sample in an amount greater than said predetermined cutoff amount confirms the active intake of marijuana by said test subject.
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Abstract
A method for confirming the active intake of marijuana and its active component Δ9-tetrahydrocannabinol (“Δ9-THC”) by detecting the amount of 11-nor-Δ9-THC carboxylic acid (“THCA”) in oral fluid at the picogram per milliliter (pg/ml) level using chromatography/mass spectrometry/mass spectrometry (“GC/MS/MS”).
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Citations
60 Claims
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1. A method for confirming the active intake of marijuana in a test subject comprising the steps of:
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obtaining a test sample of oral fluid from said test subject; and detecting the amount of 11-nor-Δ
9 THC carboxylic acid (“
THCA”
) in said test sample,wherein said THCA has not been externally added to said test sample and said amount of THCA is less than about 240 pg/ml but greater than a predetermined cutoff amount; wherein the presence of THCA in said test sample in an amount greater than said predetermined cutoff amount confirms the active intake of marijuana by said test subject. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18)
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19. A method for testing whether a test subject has falsely tested negative for the active intake of marijuana comprising the steps of:
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obtaining a test sample of oral fluid from said test subject who has tested negative for active marijuana intake; and detecting the amount of 11-nor-Δ
9 THC carboxylic acid (“
THCA”
) in said oral fluid in said test sample, wherein said THCA has not been externally added to said test sample and said amount of THCA is less than about 240 pg/ml but greater than a predetermined cutoff amount;wherein the presence of THCA in said test sample in an amount greater than said predetermined cutoff amount indicates the active intake of marijuana by said test subject. - View Dependent Claims (20, 21, 22, 23, 24, 33)
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25. A method for determining active intake of marijuana by a subject, comprising:
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(i) detecting by an assay an amount of 11-nor-Δ
9 THC carboxylic acid (“
THCA”
) in an oral fluid sample from said subject, wherein said assay is capable of detecting THCA in the pg/ml range; and(ii) comparing said detected amount of THCA with a cutoff value wherein said cutoff value is a value between about 10 pg/ml and about 30 pg/ml, wherein when said amount of THCA detected is higher than said cutoff value, active intake of marijuana by said subject is indicated. - View Dependent Claims (26, 27, 28, 29, 30, 31, 32, 34, 35, 36, 37)
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38. A method for determining active intake of marijuana by a subject, comprising:
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(i) detecting by an assay an amount of 11-nor-Δ
9 THC carboxylic acid (“
THCA”
) in an oral fluid sample from said subject, wherein said assay is capable of detecting THCA in the pg/ml range; and(ii) comparing said detected amount of THCA with a control amount of THCA in a control sample of oral fluid from a control subject, who has not actively consumed marijuana, wherein when said amount of THCA detected is higher than said control amount of THCA by a preset differential of between about 10 pg/ml and about 240 pg/ml, active intake of marijuana by said subject is indicated. - View Dependent Claims (39, 40, 41)
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42. A method for determining whether a subject has falsely tested negative for active intake of marijuana, comprising:
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(i) detecting by an assay an amount of 11-nor-Δ
9 THC carboxylic acid (“
THCA”
) in an oral fluid sample from said subject, wherein said assay is capable of detecting THCA in the pg/ml range; and(ii) comparing said detected amount of THCA with a control amount of THCA in a control sample of oral fluid from a control subject, who has not actively consumed marijuana, wherein when said detected amount of THCA is higher than said control amount of THCA by a preset differential of between about 10 pg/ml and about 240 pg/ml said subject falsely tested negative for active intake of marijuana is indicated. - View Dependent Claims (43, 44, 45)
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46. A method for determining active intake of marijuana by a subject, comprising:
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(i) detecting a specified amount of 11-nor-Δ
9 THC carboxylic acid (“
THCA”
) in an oral fluid sample from said subject by mass spectrometry, and(ii) comparing said detected amount of THCA with a cutoff value wherein said cutoff value is a value between about 10 pg/ml and about 30 pg/ml, wherein when said amount of THCA detected is higher than said cutoff value, active intake of marijuana by said subject is indicated; and
wherein said mass spectrometry is capable of detecting the amount of THCA in said sample in the pg/ml range.- View Dependent Claims (47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60)
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Specification