Dual electrode system for a continuous analyte sensor
First Claim
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1. An analyte sensor configured for insertion into a host for measuring an analyte in the host, the sensor comprising:
- a first working electrode disposed beneath an active enzymatic portion of a membrane;
a second working electrode disposed beneath an inactive-enzymatic or non-enzymatic portion of a membrane; and
a non-conductive material located between the first working electrode and the second working electrode, wherein the first working electrode and the second working electrode are intertwined.
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Abstract
Disclosed herein are systems and methods for a continuous analyte sensor, such as a continuous glucose sensor. One such system utilizes first and second working electrodes to measure additional analyte or non-analyte related signal. Such measurements may provide a background and/or sensitivity measurement(s) for use in processing sensor data and may be used to trigger events such as digital filtering of data or suspending display of data.
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Citations
92 Claims
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1. An analyte sensor configured for insertion into a host for measuring an analyte in the host, the sensor comprising:
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a first working electrode disposed beneath an active enzymatic portion of a membrane; a second working electrode disposed beneath an inactive-enzymatic or non-enzymatic portion of a membrane; and a non-conductive material located between the first working electrode and the second working electrode, wherein the first working electrode and the second working electrode are intertwined. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16)
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17. A glucose sensor configured for insertion into a host for measuring a glucose concentration in the host, the sensor comprising:
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a first working electrode configured to generate a first signal associated with glucose and non-glucose related electroactive compounds, the glucose and non-glucose related electroactive compounds having a first oxidation potential; a second working electrode configured to generate a second signal associated with non-glucose related electroactive compounds with an oxidation potential that substantially overlaps with the first oxidation potential, wherein the first and second working electrodes are at least one of bundled and twisted; and a non-conductive material located between the first working electrode and the second working electrode. - View Dependent Claims (18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44)
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45. An analyte sensor configured for insertion into a host for measuring an analyte in the host, the sensor comprising:
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a first working electrode comprising a first electroactive surface disposed beneath an active enzymatic portion of a membrane, wherein the first working electrode defines a first longitudinal axis; a second working electrode comprising a second electroactive surface disposed beneath an inactive-enzymatic or non-enzymatic portion of a membrane, wherein the second working electrode defines a second longitudinal axis that is co-linear with the first longitudinal axis, both of which define a longitudinal axis of the sensor; and an insulator located between the first electroactive surface and the second electroactive surface, wherein the sensor comprises a diffusion barrier configured to substantially block diffusion of at least one of an analyte and a co-analyte between the first electroactive surface and the second electroactive surface wherein the analyte sensor is configured to indwell in a blood stream of the host, and wherein the diffusion barrier comprises an offset of the first electroactive surface and the second electroactive surface along the longitudinal axis of the sensor that provides a flow path diffusion barrier configured to block or avoid a substantial amount of diffusion of at least one of the analyte and the co-analyte between the first electroactive surface and the second electroactive surface. - View Dependent Claims (46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60)
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61. A glucose sensor configured for insertion into a host for measuring a glucose concentration in the host, the sensor comprising:
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a first working electrode configured to generate a first signal associated with glucose and non-glucose related electroactive compounds, the glucose and non-glucose related electroactive compounds having a first oxidation potential; a second working electrode configured to generate a second signal associated with noise of the glucose sensor comprising signal contribution due to non-glucose related electroactive compounds with an oxidation potential that substantially overlaps with the first oxidation potential, wherein the first and second working electrodes are twisted together along a longitudinal axis defined by longitudinal axes of the first and second electrodes; and a non-conductive material located between the first working electrode and the second working electrode, wherein the sensor comprises a diffusion barrier configured to substantially block diffusion of at least one of the analyte and the co-analyte between the first working electrode and the second working electrode. - View Dependent Claims (62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 76)
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74. A glucose sensor configured for insertion into a host for measuring a glucose concentration in the host, the sensor comprising:
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a first working electrode configured to generate a first signal associated with glucose and non-glucose related electroactive compounds, the glucose and non-glucose related electroactive compounds having a first oxidation potential; and a second working electrode configured to generate a second signal associated with non-glucose related electroactive compounds with an oxidation potential that substantially overlaps with the first oxidation potential, wherein the first working electrode and the second working electrode are interdigitated. - View Dependent Claims (75, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92)
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Specification