Reflectometry instrument and method for measuring macular pigment

• US 7,467,870 B2
• Filed: 04/27/2006
• Issued: 12/23/2008
• Est. Priority Date: 04/27/2006
• Status: Active Grant

• Current Assignee: Zeavision LLC
• Original Assignee: Zeavision LLC
• Inventors: van Norren, Dirk, Berendschot, Tos T. J. M., van de Kraats, Jan
• Primary Examiner(s): MAI, HUY KIM
• Application Number:
  US11/412,993
• Publication Number:
  US 20070252950A1
• Time in Patent Office: 971 Days
• Field of Search: 351/200, 351/205, 351/206, 351/207, 351/213, 351/214, 351/220, 351/221, 351/246
• US Class Current: 351/221
• CPC Class Codes: A61B 3/1176 for determining lens opacity, e.g. cataract
• CPC Class Codes: A61B 3/12 for looking at the eye fundus, e.g. ophthalmoscopes A61B3/13 takes precedence
• CPC Class Codes: A61B 3/1208 Multiple lens hand-held instruments
• CPC Class Codes: A61B 3/156 for blocking

Abstract

A reflectometry instrument includes a light source, a spectrometer, and a first and second lens. The light source emits an illumination beam to the macula. The spectrometer measures a detection beam that is a portion of the illumination beam reflected from the eye and is indicative of the eye characteristics (e.g. macular pigment). The first and second lenses transmit the illumination beam to the macula and transmit the detection beam from the macula to the spectrometer. The instrument is used on an undilated pupil and minimizes unwanted reflections by at least one of the following: the first and second lenses include anti-reflection coatings; the illumination and detection beams pass through the first and second lenses at locations offset from their centers; and the illumination and the detection beams remain separated when passing through the first and second lenses. Zeaxanthin, lutein, and the total macular pigment levels are measured by the instrument.

Claims

1. A reflectometry instrument to measure macular pigment of a macula of a human eye, comprising:

a light source for emitting an illumination beam in a direction toward the macula;

a spectrometer for measuring a detection beam, the detection beam being a portion of the illumination beam reflected from the macula, the detection beam being indicative of the amount of macular pigment in the macula;

a first lens for transmitting the illumination beam to the macula and for transmitting the detection beam from the macula to the spectrometer, the first lens including an anti-reflection coating; and

a second lens adjacent to the first lens, the second lens being adapted to transmit the illumination beam to the macula and for transmitting the detection beam from the macula to the spectrometer, the second lens including an anti-reflection coating,

wherein the illumination beam and the detection beam remain separated when the illumination beam and the detection beam pass through the first lens and the second lens.

2. The reflectometry instrument of claim 1, wherein the anti-reflection coatings of the first lens and the second lens has a maximum reflectance of 1 percent in the range of about 400 nm to about 500 nm for normal light incidence.

3. The reflectometry instrument of claim 2, wherein the anti-reflection coatings have a reflectance less than 0.3 percent in the 400-450 nm range for normal light incidence.

4. The reflectometry instrument of claim 3, wherein the first lens and the second lens are made of material including crown and flint glasses.

5. The reflectometry instrument of claim 1, wherein the illumination beam and the detection beam are transmitted through the first lens and the second lens at locations offset from the centers of the first and second lenses.

6. The reflectometry instrument of claim 1, wherein the separation of the illumination beam and detection beams occurs in the first and second lens and frontal parts of the eye when using a retinal field of about 1 degree.

7. The reflectometry instrument of claim 1, wherein the separation of the illumination beam and detection beams occurs in an undilated pupil of the eye.

8. The reflectometry instrument of claim 1, further comprising a mirror for turning the illumination beam from the light source toward the first lens, the detection beam being adapted to pass by the mirror without contacting the mirror, the spectrometer being located behind the mirror.

9. The reflectometry instrument of claim 1, in combination with computer code that varies and determines eye-related variables to create a modeled spectral reflectance curve that approximates an actual spectral reflectance curve measured by the spectrometer, at least one of the eye-related variables being a macular pigment amount.

10. The reflectometry instrument of claim 1, in combination with computer code that varies and determines eye-related variables to create a modeled spectral reflectance curve that approximates an actual spectral reflectance curve measured by the spectrometer, at least one of the eye-related variables being a lutein-macular pigment amount and at least one of the eye-related variables being a zeaxanthin-macular pigment amount.

11. A reflectometry instrument to measure macular pigment of a macula of a human eye, comprising:

a light source for emitting an illumination beam in a direction toward the macula;

a spectrometer for measuring a detection beam, the detection beam being a portion of the illumination beam reflected from the macula, the detection beam being indicative of the amount of macular pigment in the macula;

a first lens for transmitting the illumination beam to the macula and for transmitting the detection beam from the macula to the spectrometer, the illumination beam and the detection beam being transmitted by the first lens at a location offset from the center of the first lens; and

a second lens adjacent to the first lens, the second lens for transmitting the illumination beam to the macula and for transmitting the detection beam from the macula to the spectrometer, the illumination beam and the detection beam being transmitted by the second lens at a location offset from the center of the second lens,

wherein the illumination beam and the detection beam remain separated when the illumination beam and the detection beam pass through the first lens and the second lens.

12. The reflectometry instrument of claim 11, wherein the transmission of the illumination beam and the detection beam through the first lens and the second lens occurs at locations that are offset from the centers of the first lens and the second lens, respectfully, by a distance in the range from about 1 mm to about 4 mm.

13. The reflectometry instrument of claim 12, wherein the offset distance is about 3 mm.

14. The reflectometry instrument of claim 11, wherein the first and second lens include crown and flint glasses and include anti-reflection coatings, the reflectance of the anti-reflection coatings being below 1 percent in the range of about 400 nm to about 500 nm for normal light incidence.

15. The reflectometry instrument of claim 14, wherein the anti-reflection coating includes a reflectance below 0.3 percent in the 400 nm to 450 nm range for normal light incidence.

16. The reflectometry instrument of claim 11, wherein the separation of the illumination beam and detection beams occurs in the first and second lens and the frontal parts of the eye when using a retinal field of about 1 degree.

17. The reflectometry instrument of claim 11, wherein the illumination beam travels along an illumination path, the detection beam travels along a detection path, the illumination path and the detection path intersect between the first and second lenses.

18. The reflectometry instrument of claim 11, in combination with computer code that varies and determines eye-related variables to create a modeled spectral reflectance curve that approximates an actual spectral reflectance curve measured by the spectrometer, at least one of the eye-related variables being a macular pigment amount.

19. The reflectometry instrument of claim 11, in combination with computer code that varies and determines eye-related variables to create a modeled spectral reflectance curve that approximates an actual spectral reflectance curve measured by the spectrometer, at least one of the eye-related variables being a lutein-macular pigment amount and at least one of the eye-related variables being a zeaxanthin-macular pigment amount.

20. A method of determining the amount of macular pigment in the macula of a human eye, comprising:

passing an illumination beam through a lens system having a first lens and a second lens, the illumination beam passing through the first lens and the second lens at locations offset from the centers of the first lens and second lens;

directing the illumination beam from the lens system onto the macula so as to produce a detection beam that reflects from the eye;

were

passing the detection beam through the lens system offset from the centers of the first lens and second lens, the detection beam remaining separated from the illumination beam at the first lens and the second lens;

receiving the detection beam at a spectrometer; and

measuring characteristics of the detection beam at the spectrometer.

21. The method of claim 20, wherein the illumination beam travels along an illumination path and the detection beam travels along a detection path in the lens system, and wherein the passing the illumination beam includes:

producing the illumination beam from a source in a direction that is transverse to the illumination path, and

reflecting the illumination beam with a mirror so as to pass the illumination beam along the illumination path through the lens system.

22. The method of claim 21, wherein the illumination beam passes through an illumination mask prior to the reflecting the illumination beam with the mirror to cause the illumination beam to have a partial-circle beam profile.

23. The method of claim 22, wherein the detection beam passes by the mirror without contacting the mirror, the spectrometer being located behind the mirror.

24. The method of claim 22, wherein the detection beam passes through a detection mask subsequent to the passing by the mirror to cause the detection beam to have a partial-circle beam profile.

25. The method of claim 21, wherein the source includes a halogen lamp and filters for filtering ultraviolet energy from the illumination beam.

26. The method of claim 25, wherein the source further includes lenses and masks for producing a beam size for passing to an undilated pupil.

27. The method of claim 20, wherein the first and second lens include a coating that has a reflection that is less than about 0.3% in the range of about 400 to about 450 nm for normal light incidence.

28. The method of claim 20, further including creating a modeled spectral reflectance curve that approximates an actual spectral reflectance curve measured by the spectrometer, the creating includes determining values for a plurality of eye-related variables.

29. The method of claim 28, wherein one of the plurality of eye-related variables is an amount of macular pigment.

30. The method of claim 28, wherein one of the plurality of eye-related variables is an amount of zeaxanthin macular pigment and another of the plurality of eye-related variables is an amount of lutein macular pigment.

31. The method of claim 28, wherein one of the plurality of eye-related variables relates to a characteristic of the lens in the eye.

32. The method of claim 31, wherein the characteristic is indicative of the patient having a cataract.

34. The instrument of claim 32, wherein the lens characteristic is indicative of the patient having a cataract.

35. The instrument of claim 32, wherein the anti-reflection coatings of the first lens and the second lens has a maximum reflectance of 1 percent in the range of about 400 nm to about 500 nm.

36. The instrument of claim 32, wherein the illumination beam and the detection beam are transmitted through the first lens and the second lens at locations offset from the centers of the first and second lenses.

33. A reflectometry instrument to measure a lens characteristics of a human eye, comprising:

a light source for emitting an illumination beam in a direction toward the eye;

a spectrometer for measuring a detection beam, the detection beam being a portion of the illumination beam reflected from the eye, the detection beam being indicative of the lens characteristic in the eye;

a first lens for transmitting the illumination beam to the eye and for transmitting the detection beam from the eye to the spectrometer, the first lens including an anti-reflection coating; and

a second lens adjacent to the first lens, the second lens being adapted to transmit the illumination beam to the eye and for transmitting the detection beam from the eye to the spectrometer, the second lens including an anti-reflection coating,

wherein the illumination beam and the detection beam remain separated when the illumination beam and the detection beam pass through the first lens and the second lens.