Method and apparatus for muscle function measurement

• US 7,470,233 B2
• Filed: 01/26/2005
• Issued: 12/30/2008
• Est. Priority Date: 01/26/2005
• Status: Active Grant

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Bennett, Tommy D., Karamanoglu, Mustafa, Splett, Vincent E.
• Primary Examiner(s): Marmor, II; Charles A
• Assistant Examiner(s): SAIDI, AZADEH
• Application Number:
  US11/043,819
• Publication Number:
  US 20060167358A1
• Time in Patent Office: 1,434 Days
• Field of Search: 600/485, 600/486, 600/300, 600/324, 600/325, 600/333, 600/335, 600/341, 600/345, 600/348, 600/373, 600/374, 600/377, 600/508, 600/561, 600/488, 600/513, 600515-518, 600/510, 600/587, 607/6, 607/7, 607/17, 607/19, 607/23, 607/24, 607/4, 607/5, 607/9, 607/119, 607121-123, 128/903, 604/67, 604/288.01, 604/93.01
• US Class Current: 600/485
• CPC Class Codes: A61B 5/0215 by means inserted into the body catheters A61M25/00
• CPC Class Codes: A61B 5/4519 Muscles A61B5/389, A61B5/224 take precedence
• CPC Class Codes: A61B 5/7239 using differentiation including higher order derivatives

Abstract

The present invention provides an apparatus and method for monitoring muscle function based on an index derived from a pressure or force signal. The muscle function index is derived from an instantaneous muscle stiffness ratio computed as the ratio of the first time derivative of the pressure or force waveform to the corresponding instantaneous pressure or force. The instantaneous stiffness ratio, Ė/E(t), is in units of 1/sec and relates to the rate of strong bond formation and will be influenced by calcium handling properties of the muscle fibers and the intracellular calcium concentration. As such, an index derived from Ė/E(t) provides a measure of the inotropic status of the muscle.

Claims

1. A method, comprising:

sensing a pressure signal associated with a muscular contraction event via a chronically-implantable pressure sensor coupled to a chronically implanted medical device;

computing an instantaneous stiffness ratio waveform as a ratio of a first time derivative of the pressure signal to an instantaneous pressure metric within said IMD; and

deriving an index of muscle function from the instantaneous stiffness ratio waveform within said IMD,

wherein the computing and deriving steps of said method are carried out within via operative circuitry wholly disposed within said IMD; and

wherein the index of muscle function comprises a peak of the stiffness ratio waveform.

2. A method according to claim 1, wherein the pressure signal comprises a cardiac chamber pressure signal.

3. A method according to claim 1, wherein the muscular contraction event comprises at least part of one of a myocardial depolarization sequence and a myocardial repolarization event.

4. A method according to claim 1, wherein the pressure signal is obtained using an intracardiac pressure transducer.

5. A method according to claim 4, wherein the intracardiac pressure transducer is adapted to be disposed within a portion of a right ventricular chamber.

6. A method, comprising:

sensing a force signal associated with a muscular contraction event, wherein the force signal is provided by a chronically-implantable sensor which is coupled to a chronically implanted medical device (IMD);

computing an instantaneous stiffness ratio waveform as a ratio of a first time derivative of the force signal to an instantaneous force metric within the IMD; and

deriving an index of muscle function from the stiffness ratio waveform within the IMD

wherein the computing and deriving steps are performed via circuitry disposed within the. IMD; and

wherein the index of muscle function comprises a peak of the stiffness ratio waveform.

7. A method according to claim 6, wherein the force signal comprises a cardiac chamber force signal.

8. A method according to claim 6, wherein the muscular contraction event comprises at least part of one of a myocardial depolarization sequence and a myocardial repolarization event.

9. A method according to claim 6, wherein the force signal is obtained using an intracardiac force transducer.

10. A method according to claim 9, wherein the intracardiac force transducer is adapted to be disposed within a portion of a right ventricular chamber.

11. A chronically implantable medical device (IMD), comprising:

means for sensing a pressure signal associated with a muscular contraction event wherein the pressure signal is provided by a chronically-implantable sensor and said sensor couples to the (IMD);

means within the IMD for computing an instantaneous stiffness ratio waveform as the ratio of the first time derivative of the pressure signal to the instantaneous pressure; and

means within the IMD for deriving an index of muscle function as a feature of the instantaneous stiffness ratio waveform; and

wherein the index of muscle function comprises a peak of the stiffness ratio waveform.

12. An apparatus according to claim 11, wherein the means for sensing the pressure signal comprises at least one fluid pressure transducer, and wherein the at least one fluid pressure transducer is adapted for deployment into fluid communication to a portion of the venous system of a subject.

13. A device according to claim 11, wherein the pressure signal comprises a cardiac chamber pressure signal.

14. A device according to claim 11, wherein the muscular contraction event comprises at least part of one of a myocardial depolarization sequence and a myocardial repolarization event.

15. A device according to claim 11, wherein the pressure signal sensing means comprises an intracardiac pressure transducer.

16. A method according to claim 11, wherein the intracardiac pressure transducer is adapted to be disposed within a portion of a right ventricular chamber.

17. A chronically implantable medical device (IMD), comprising:

means for sensing a force signal associated with a muscular contraction event wherein the force signal is provided by a chronically-implantable sensor and said sensor couples to the (IMD);

means within the IMD for computing an instantaneous stiffness ratio waveform as the ratio of the first time derivative of the force signal to instantaneous force; and

means within the IMD for deriving an index of muscle function as a feature of the instantaneous stiffness ratio waveform; and

wherein the index of muscle function comprises a peak of the stiffness ratio waveform.

18. A device according to claim 17, wherein the force signal comprises a cardiac chamber force signal.

19. A device according to claim 17, wherein the muscular contraction event comprises at least part of one of a myocardial depolarization sequence and a myocardial repolarization event.

20. A device according to claim 17, wherein the force signal sensing means comprises an intracardiac force transducer.

21. A method according to claim 17, wherein the intracardiac force transducer is adapted to be disposed within a portion of a right ventricular chamber.