Biodegradable drug delivery material for stent
First Claim
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1. A coated stent comprising:
- a stent body in a size suitable for implantation in a blood vessel; and
a coating covering at least a portion of the stent body, the coating including a biodegradable terpolymer having three different types of units from three different monomers and comprising anhydride-derived and imide-derived units,wherein the terpolymer is bulk-erosion resistant when implanted into a lumen of a patient and subjected to blood flow.
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Abstract
A stent is fabricated utilizing a polymer that is selected for its tendency to degrade from the surface inwardly rather than undergo bulk erosion so as to substantially reduce the risk of large particles becoming detached and being swept downstream. Such polymer is hydrophobic yet has water-labile linkages interconnecting the monomers. Ester or imide bonds are incorporated in the polymer to render the surface degrading materials suitable for use in stent applications. The stent may be coated with such polymer or may be wholly formed therefrom.
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Citations
12 Claims
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1. A coated stent comprising:
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a stent body in a size suitable for implantation in a blood vessel; and a coating covering at least a portion of the stent body, the coating including a biodegradable terpolymer having three different types of units from three different monomers and comprising anhydride-derived and imide-derived units, wherein the terpolymer is bulk-erosion resistant when implanted into a lumen of a patient and subjected to blood flow. - View Dependent Claims (2, 3, 4)
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5. A coated stent comprising:
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a stent body in a size suitable for use in a blood vessel; and a coating covering at least a portion of the stent body, the coating including a biodegradable terpolymer having three different types of units from three different monomers and comprising anhydride-derived and imide-derived units in the amount of 20% to 40% of the polymer, wherein the terpolymer is bulk-erosion resistant when implanted into a lumen of a patient and subjected to blood flow. - View Dependent Claims (6, 7, 8, 9, 10)
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11. A coated stent comprising:
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a stent body; and a coating covering at least a portion of the stent body, the coating including a biodegradable terpolymer having three different types of units from three different monomers and comprising anhydride-derived and imide-derived units in the amount of 20% to 40% of the polymer, wherein the terpolymer is bulk-erosion resistant when implanted into a lumen of a patient and subjected to blood flow, and wherein the terpolymer has a degradation rate that is faster than the rate of water penetration into the interior of the polymer after the stent is implanted into the lumen of the patient.
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12. A coated stent comprising:
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a stent body; and a coating covering at least a portion of the stent body, the coating including a biodegradable terpolymer having three different types of units from three different monomers and comprising anhydride-derived and imide-derived units in the amount of 20% to 40% of the polymer, wherein the terpolymer is bulk-erosion resistant when implanted into a lumen of a patient and subjected to blood flow, and wherein the terpolymer further comprises a biodegradable polymer comprising fragments having water-labile ester or imide bonds.
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Specification