Nanoparticle structures and composite materials comprising a silicon-containing compound having a chemical linker that forms a non-covalent bond with a polymer

• US 7,470,466 B2
• Filed: 12/23/2005
• Issued: 12/30/2008
• Est. Priority Date: 12/23/2005
• Status: Expired due to Fees

• Current Assignee: Boston Scientific Scimed, Inc. (Boston Scientific Corporation)
• Original Assignee: Boston Scientific Scimed, Inc. (Boston Scientific Corporation)
• Inventors: Atanasoska, Liliana L., Warner, Robert W., Ippoliti, J. Thomas, Schewe, Scott R.
• Primary Examiner(s): LE, HOA T
• Application Number:
  US11/317,963
• Publication Number:
  US 20070148461A1
• Time in Patent Office: 1,103 Days
• Field of Search: 428/402, 428/403, 977/700, 977/773
• US Class Current: 428/402
• CPC Class Codes: B82Y 30/00 Nanotechnology for materials or surface science, e.g. nanocomposites
• CPC Class Codes: C08J 5/005 Reinforced macromolecular compounds with nanosized materials, e.g. nanoparticles, nanofibres, nanotubes, nanowires, nanorods or nanolayered materials
• CPC Class Codes: C08K 9/04 Ingredients treated with organic substances treated with macromolecular compounds C08K9/08
• CPC Class Codes: Y10S 977/773 Nanoparticle, i.e. structure having three dimensions of 100 nm or less
• CPC Class Codes: Y10S 977/778 within specified host or matrix material, e.g. nanocomposite films
• CPC Class Codes: Y10S 977/783 Organic host/matrix, e.g. lipid
• CPC Class Codes: Y10T 428/2982 Particulate matter [e.g., sphere, flake, etc.]
• CPC Class Codes: Y10T 428/2991 Coated
• CPC Class Codes: Y10T 428/2993 Silicic or refractory material containing [e.g., tungsten oxide, glass, cement, etc.]
• CPC Class Codes: Y10T 428/2998 including synthetic resin or polymer
• CPC Class Codes: Y10T 428/31663 As siloxane, silicone or silane

Abstract

Nanoparticle precursor structures, nanoparticle structures, and composite materials that include the nanoparticle structures in a polymer to form a composite material. The nanoparticle structures have chemical linkage moieties capable of forming non-covalent bonds with portions of a polymer for the composite material. Such composite materials are useful as biomaterials in medical devices.

Claims

1. A nanoparticle structure comprising a compound of the formula [(Si—

O)_n—

(Si—

O)_m]—

(R₂-A-R)_r;

where A is a chemical linkage moiety that can form a non-covalent bond with a polymer, R and R₂ are each independently an organic group;

n, m and p are each independently in a polymeric range;

r is at least 25 percent of n.

2. The nanoparticle structure of claim 1, where the nanoparticle structure is derived from a nanoparticle precursor structure of the formula (R₁O)_wSi(R₂-A-R)_z and at least one silicon alkoxide of the formula Si(OR₃)₄ in a sol-gel process, where A is the chemical linkage moiety that can form a non-covalent bond with the polymer, R, R₁, R₂ and R₃ are each independently an organic group, and w and z are each independently 1 to 3.

3. The nanoparticle structure of claim 2, where [(Si—

O)_n—

(Si—

O)_m]_p is a silicon oxide based polymer that forms a nanoparticle from which the groups (R₂-A-R)_r extend.

4. The nanoparticle structure of claim 3, where the silicon oxide based polymer of the nanoparticle is formed using the sol-gel process.

5. The nanoparticle structure of claim 2, where A is a urethane group.

6. The nanoparticle of claim 2, where R is a (C1-C8)alkyl group and R₂ is a (C1-C18)alkylene group.