Oxidant scavengers

• US 7,470,677 B2
• Filed: 06/09/2003
• Issued: 12/30/2008
• Est. Priority Date: 10/15/1993
• Status: Expired due to Fees

• Current Assignee: Aeolus Sciences Incorporated, Duke University, University of Alabama At Birmingham (University of Alabama System)
• Original Assignee: Aeolus Pharmaceuticals, Inc.
• Inventors: Fridovich, Irwin, Trova, Michael P., Batinic-Haberle, Ines, Day, Brian J., Crapo, James D., Freeman, Bruce A., Folz, Rodney J., Oury, Tim
• Primary Examiner(s): Richter; Johann
• Assistant Examiner(s): Arnold; Ernst V
• Application Number:
  US10/457,071
• Publication Number:
  US 20040019031A1
• Time in Patent Office: 2,031 Days
• Field of Search: 540/145, 540/201, 514/185, 514/492, 424/78.15, 424/630, 424/639, 424/646
• US Class Current: 514/185
• CPC Class Codes: A61K 31/00 Medicinal preparations containing organic active ingredients
• CPC Class Codes: A61K 31/555 containing heavy metals, e.g. hemin, hematin, melarsoprol

Abstract

The present invention relates, in general, to a method of modulating physiological and pathological processes and, in particular, to a method of modulating intra- and extracellular levels of oxidants and thereby processes in which such oxidants are a participant. The invention also relates to compounds and compositions suitable for use in such methods.

Claims

1. A method of protecting cells from oxidant-induced toxicity comprising contacting said cells with a non-toxic amount of a scavenger of the formula,

2. The method according to claim 1 wherein said cells are mammalian cells or plant cells.

3. A method of inhibiting damage due to oxidation of a substance comprising contacting to said substance with a non-toxic amount of a scavenger of the formula,