Sensor head for use with implantable devices
First Claim
1. A sensor for use in a glucose measuring device, the sensor comprising:
- a first electrode, a second electrode, and a non-conductive body located between the first electrode and the second electrode, wherein the first electrode and the second electrode each form an electrochemically reactive surface at one end of the sensor and an electronic connection at another end of the sensor, wherein an electrochemically reactive surface area of the second electrode is greater than an electrochemically reactive surface area of the first electrode; and
a multi-region membrane covering the first electrode and the second electrode, wherein the multi-region membrane comprises an immobilized enzyme domain comprising an enzyme in at least a portion thereof, and wherein the immobilized enzyme is deactivated over the electrochemical reactive surface area of second electrode.
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Abstract
The present invention provides a sensor head for use in an implantable device that measures the concentration of an analyte in a biological fluid which includes: a non-conductive body; a working electrode, a reference electrode and a counter electrode, wherein the electrodes pass through the non-conductive body forming an electrochemically reactive surface at one location on the body and forming an electronic connection at another location on the body, further wherein the electrochemically reactive surface of the counter electrode is greater than the surface area of the working electrode; and a multi-region membrane affixed to the nonconductive body and covering the working electrode, reference electrode and counter electrode. In addition, the present invention provides an implantable device including at least one of the sensor heads of the invention and methods of monitoring glucose levels in a host utilizing the implantable device of the invention.
1133 Citations
22 Claims
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1. A sensor for use in a glucose measuring device, the sensor comprising:
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a first electrode, a second electrode, and a non-conductive body located between the first electrode and the second electrode, wherein the first electrode and the second electrode each form an electrochemically reactive surface at one end of the sensor and an electronic connection at another end of the sensor, wherein an electrochemically reactive surface area of the second electrode is greater than an electrochemically reactive surface area of the first electrode; and a multi-region membrane covering the first electrode and the second electrode, wherein the multi-region membrane comprises an immobilized enzyme domain comprising an enzyme in at least a portion thereof, and wherein the immobilized enzyme is deactivated over the electrochemical reactive surface area of second electrode. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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13. A sensor for use in a glucose measuring device, the sensor comprising:
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a first electrode, a second electrode, and a non-conductive body located between the first electrode and the second electrode, wherein the first electrode and the second electrode each form an electrochemically reactive surface at one end of the sensor and an electronic connection at another end of the sensor; and a multi-region membrane covering the first electrode and the second electrode, wherein the multi-region membrane comprises an immobilized enzyme domain comprising an active enzyme in at least a portion thereof, and wherein the electrochemical reactive surface area of the second electrode is situated at a location distant from the active enzyme. wherein the immobilized enzyme is deactivated over the second electrode. - View Dependent Claims (14, 15, 16, 17, 18, 19, 20, 21, 22)
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Specification