Measurement of a blood flow rate in hemodialysis shunts

• US 7,473,371 B2
• Filed: 04/13/2005
• Issued: 01/06/2009
• Est. Priority Date: 09/16/1994
• Status: Expired due to Fees

• Current Assignee: Transonic Systems, Inc. (Measurement Innovations Corp.)
• Original Assignee: Transonic Systems, Inc. (Measurement Innovations Corp.)
• Inventors: MacGibbon, David R., Krivitski, Nikolai M.
• Primary Examiner(s): KIM, SUN U
• Application Number:
  US11/104,947
• Publication Number:
  US 20050178732A1
• Time in Patent Office: 1,364 Days
• Field of Search: 210/85, 210/87, 210/90, 210/97, 210/646, 210/739, 210/745, 604/4.01, 604/5.01, 600/504, 600/505, 738/61, 738/610.1, 738/610.5, 738/619.5, 738/610.7, 738/610.8, 738/611.8
• US Class Current: 210/739
• CPC Class Codes: A61B 5/0275 using tracers, e.g. dye dilution
• CPC Class Codes: A61M 1/16 with membranes
• CPC Class Codes: A61M 1/3623 Means for actively controlling temperature of blood
• CPC Class Codes: A61M 1/3653 Interfaces between patient blood circulation and extra-corporal blood circuit
• CPC Class Codes: A61M 1/3655 Arterio-venous shunts or fistulae
• CPC Class Codes: A61M 1/3658 Indicating the amount of purified blood recirculating in the fistula or shunt
• CPC Class Codes: A61M 1/3663 Flow rate transducers; Flow integrators
• CPC Class Codes: A61M 1/3669 Electrical impedance measurement of body fluids; transducers specially adapted therefor
• CPC Class Codes: A61M 1/367 Circuit parts not covered by the preceding subgroups of group A61M1/3621

Abstract

The measurement of blood flow in a dialysis shunt is obtained by injection of an indicator material into a venous line leading from dialysis equipment to the shunt. The blood flow in an arterial line leading from the shunt at a location downstream of the venous line to the dialysis equipment is monitored by an arterial line sensor for the presence of the indicator material. A detector connected to the sensor provides a dilution curve in response to the presence of the indicator material and the blood flow in the shunt is calculated from the area under the dilution curve. The locations of the arterial and venous lines in the shunt can be reversed to obtain a measurement of blood recirculation from the venous line into the arterial line.

Claims

1. A method for obtaining a measure of blood flow rate in a patient arterio-venous shunt, the arterio-venous shunt being connected to an extracorporeal blood circulating system, the extracorporeal blood circulating system having a dialyzer connected to the arterio-venous shunt by a first and a second line, wherein the first line directs blood from the arterio-venous shunt to the dialyzer and the second line directs blood from the dialyzer to the arterio-venous shunt, the method comprising the steps of:

(a) connecting the dialyzer to the arterio-venous shunt with an inlet of the first line located downstream from an outlet of the second line;

(b) providing a change in a parameter of the blood flowing in the extracorporeal blood circulating system; and

(c) obtaining the measure of blood flow rate in the arterio-venous shunt based upon a resulting dilution curve by the change in said parameter of the blood and a dialyzer blood flow rate.

2. The method of claim 1 wherein the step of providing a change in a parameter of the blood comprises the step of introducing an indicator into the blood.

3. The method of claim 2 wherein the step of introducing an indicator is selected from the group consisting of introducing the indicator into the first line, introducing the indicator into the second line, and introducing the indicator by the dialyzer.

4. The method of claim 2 wherein the step of introducing an indicator is one of:

introducing a saline solution, introducing sodium, introducing an isotope, introducing a temperature change and introducing a blood treatment adjustment.

5. The method of claim 2 wherein the step of introducing an indicator produces a change in at least one of:

a temperature of the blood, an electrical impedance of the blood, a salinity of the blood, an isotope content of the blood, an ultrasonic property of the blood, and an optical characteristic of the blood.

6. The method of claim 2 wherein the step of introducing an indicator is injecting a saline solution.

7. The method of claim 1 wherein the step of providing a change in a parameter of the blood comprises treating blood in the dialyzer.

8. The method of claim 1 wherein the step of providing a change in a parameter of the blood includes injecting an indicator into the blood.

9. The method of claim 1 wherein the step of providing a change in a parameter of the blood includes injecting a saline solution into the blood.

10. The method of claim 2 wherein the step of introducing an indicator is the step of changing the temperature of the blood entering the arterio-venous shunt from the second line.

11. The method of claim 1 wherein the step of providing a change in a parameter of the blood entails changing at least one of the following blood parameters of the blood flowing in the extracorporeal blood circulating system:

a temperature of the blood, an electrical impedance of the blood, a sodium content of the blood, an isotope content of the blood, an ultrasonic property of the blood and an optical characteristic of the blood.

12. A method for deriving a measure of blood flow rate in an arterio-venous shunt, wherein the arterio-venous shunt is connected to a dialysis system including a dialyzer, an arterial blood line and a venous blood line which connect the dialyzer to the arterio-venous shunt, the method comprising the steps of:

(a) connecting an inlet of the arterial blood line to the arterio-venous shunt at a location downstream from an outlet of the venous blood line;

(b) imparting a change in a parameter of blood flowing in the dialysis system; and

(c) deriving the measure of blood flow rate in the arterio-venous shunt in response to the changed blood parameter and its corresponding resulting dilution curve.

13. The method of claim 12 wherein the step of imparting a change in a blood parameter comprises the step of introducing an indicator into the blood.

14. The method of claim 13 wherein the step of introducing an indicator comprises introducing the indicator into the arterial blood line, introducing the indicator into the venous blood line or introducing the indicator by the dialyzer.

15. The method of claim 13 wherein the step of introducing an indicator is introducing a saline solution, introducing an isotope, introducing a blood temperature change or introducing a blood treatment change.

16. The method of claim 13 wherein the step of introducing an indicator produces a change in at least one of the following parameters:

a temperature of the blood, an electrical impedance of the blood, a saline content of the blood, a sodium content of the blood, an isotope content of the blood, an ultrasonic property of the blood, or an optical characteristic of the blood.

17. The method of claim 13 wherein the step of introducing an indicator is injecting a saline solution.

18. The method of claim 12 wherein the step of imparting a change in a parameter of blood comprises treating blood in the dialyzer.

19. The method of claim 12 wherein the step of imparting a change in a parameter of blood is the step of injecting an indicator into the blood.

20. The method of claim 12 wherein the step of imparting a change in a parameter of blood is injecting a saline solution.

21. The method of claim 13 wherein the step of introducing an indicator is the step of changing a temperature of the blood entering the arterio-venous shunt from the venous blood line.

22. The method of claim 12 wherein the step of imparting a change in a parameter of blood entails changing a temperature of the blood, an electrical impedance of the blood, a salinity of the blood, an isotope content of the blood, an ultrasonic property of the blood or an optical characteristic of the blood.

23. A method for ascertaining a measure of blood flow rate in an arterio-venous shunt, the arterio-venous shunt being connected to a hemodialysis circulating system having a dialyzer, an arterial line and a venous line, the method comprising the steps of:

(a) connecting the arterial and venous lines to the arterio-venous shunt so that the arterial line removing blood from the arterio-venous shunt is downstream from the venous line returning blood to the arterio-venous shunt;

(b) inducing a change in a characteristic of the blood flowing in the hemodialysis circulating system; and

(c) ascertaining the measure of blood flow rate in the arterio-venous shunt based upon a resulting dilution curve by the change in said characteristic of the blood and a dialyzer blood flow rate.

34. The method of claim 23, wherein the step of inducing a change in a characteristic of the blood entails changing at least one of the following blood parameters:

a temperature of the blood, an electrical impedance of the blood, a salinity of the blood, an isotope content of the blood, an ultrasonic property of the blood and an optical characteristic of the blood.

24. A method for deriving a measure of blood flow rate in an arterio-venous shunt, the arterio-venous shunt connectable to a hemodialysis circulating system having a dialyzer, an arterial line and a venous line, the method comprising the steps of:

(a) connecting the arterial and venous lines in a way the arterial line withdrawing blood from the arterio-venous shunt is downstream from the venous line returning blood to the arterio-venous shunt;

(b) providing a change in a blood characteristic in the hemodialysis circulating system; and

(c) deriving the measure of blood flow rate in the arterio-venous shunt based upon a resulting dilution curve by the change in said blood characteristic and a dialyzer blood flow rate.

25. The method of claim 24, wherein the step of providing a change in a blood characteristic comprises the step of introducing an indicator into the blood.

26. The method of claim 25, wherein the step of introducing an indicator is selected from the group consisting of introducing the indicator into the arterial line, introducing the indicator into the venous line, and introducing the indicator into the dialyzer.

27. The method of claim 25, wherein the step of introducing an indicator is one of:

introducing a saline solution, introducing an isotope, introducing a temperature change and introducing a blood treatment change.

28. The method of claim 25, wherein the step of introducing an indicator produces a change in at least one of:

a temperature of the blood, an electrical impedance of the blood, a salinity of the blood, an isotope content of the blood, an ultrasonic property of the blood, and an optical characteristic of the blood.

29. The method of claim 25, wherein the step of introducing an indicator is injecting a saline solution.

30. The method of claim 25, wherein the step of introducing an indicator comprises introducing blood having a change in blood treatment from the dialyzer.

31. The method of claim 25, wherein the step of introducing an indicator is the step of injecting the indicator into the blood entering the arterio-venous shunt from the venous line.

32. The method of claim 31, wherein the step of injecting an indicator is injecting a saline solution.

33. The method of claim 25, wherein the step of introducing an indicator is the step of changing the temperature of the blood entering the arterio-venous shunt from the venous line.

35. The method of claim 24, wherein the step of providing a change in a blood characteristic comprises the step of introducing an indicator into the blood.

36. The method of claim 35, wherein the step of introducing an indicator is selected from the group consisting of introducing the indicator into the arterial line, introducing the indicator into the venous line, and introducing the indicator into the dialyzer.

37. The method of claim 35, wherein the step of introducing an indicator is one of:

introducing a blood salinity change, introducing an isotope, introducing a temperature change and introducing a blood treatment change.

38. The method of claim 35, wherein the step of introducing an indicator produces a change in at least one of:

a temperature of the blood, an electrical impedance of the blood, a salinity of the blood, an isotope content of the blood, an ultrasonic property of the blood, and an optical characteristic of the blood.

39. The method of claim 35, wherein the step of introducing an indicator is injecting a saline solution.

40. The method of claim 35, wherein the step of introducing an indicator comprises introducing a change in blood treatment from the dialyzer into the venous line.

41. The method of claim 35, wherein the step of introducing an indicator is the step of injecting the indicator into the blood entering the arterio-venous shunt from the venous line.

42. The method of claim 41, wherein the step of injecting an indicator is injecting a saline solution.

43. The method of claim 35, wherein the step of introducing an indicator is the step of changing the temperature of the blood entering the arterio-venous shunt from the venous line.

44. The method of claim 24, wherein the step of providing a change in a blood characteristic entails changing at least one of the following blood characteristics:

a temperature of the blood, an electrical impedance of the blood, a salinity of the blood, an isotope content of the blood, an ultrasonic property of the blood and an optical characteristic of the blood.