System and method for image reconstruction in a fiber array spectral translator system

• US 7,474,395 B2
• Filed: 02/13/2007
• Issued: 01/06/2009
• Est. Priority Date: 02/13/2006
• Status: Active Grant

• Current Assignee: Chemimage Corporation
• Original Assignee: Chemimage Corporation
• Inventors: Nelson, Matthew P., Treado, Patrick J., Neiss, Jason H.
• Primary Examiner(s): Geisel; Kara E
• Application Number:
  US11/674,552
• Publication Number:
  US 20070188747A1
• Time in Patent Office: 693 Days
• Field of Search: 356/300, 250/252.1, 348/167, 702/189
• US Class Current: 356/300
• CPC Class Codes: G01J 3/02 Details
• CPC Class Codes: G01J 3/0218 using optical fibers
• CPC Class Codes: G01J 3/0221 the fibers defining an entry slit
• CPC Class Codes: G01J 3/28 Investigating the spectrum using colour filters G01J3/51
• CPC Class Codes: G01J 3/2803 using photoelectric array detector
• CPC Class Codes: G01J 3/2823 Imaging spectrometer
• CPC Class Codes: G01N 21/255 Details, e.g. use of specially adapted sources, lighting or optical systems
• CPC Class Codes: G01N 21/274 Calibration, base line adjustment, drift correction
• CPC Class Codes: G01N 2201/0833 Fibre array at detector, resolving

Abstract

The disclosure relates generally to methods and apparatus for spectral calibration of a spectroscopic system which includes a fiber array spectral translator. One embodiment relates to a method for obtaining a first image of a known substance using a photon detector and a fiber array spectral translator having plural fibers, wherein the first image comprises at least one pixel; providing a second image of the substance wherein the second image comprises at least one pixel; comparing the first image with the second image; and adjusting at least one pixel of the first image based on the comparison of images to thereby obtain an adjusted image.

Claims

1. A method for spectral calibration, comprising:

obtaining a first image of a known substance using a photon detector and a fiber array spectral translator having plural fibers, wherein said first image comprises at least one pixel;

providing a second image of said substance wherein said second image comprises at least one pixel;

comparing said first image with said second image; and

adjusting at least one pixel of said first image based on said comparison of images to thereby obtain an adjusted image.

2. The method of claim 1 wherein said photon detector is selected from the group consisting of:

charge-coupled device (“

CCD”

), complementary metal oxide semiconductor (“

CMOS”

) detector, and focal plane array sensor.

3. The method of claim 2 wherein said first image comprises at least one row of pixels from said CCD.

4. The method of claim 3 wherein the adjusting comprises adjusting at least one row of said first image.

5. The method of claim 1 wherein the comparing comprises a correlation of said first and second images.

6. The method of claim 1 wherein said second image is a calibrated image of said substance.

7. The method of claim 1 further comprising:

obtaining a first spectrum of said substance from one of said plural fibers wherein said first spectrum comprises at least one peak;

providing a second spectrum of said substance wherein said second spectrum comprises at least one peak;

comparing at least one peak of said first spectrum to at least one peak of said second spectrum; and

adjusting said first spectrum based on said comparison of peaks.

8. The method of claim 7 wherein said second spectrum is a reference spectrum of said substance.

9. A method for spectral calibration, comprising:

obtaining a first data set representative of a first image of a known substance, wherein said first data set is obtained using a photon detector and a fiber array spectral translator having plural fibers;

providing a second data set representative of a second image of said substance;

comparing said first data set with said second data set; and

adjusting said first data set based on said comparison of said first and second data sets.

10. The method of claim 9 wherein said photon detector is selected from the group consisting of:

charge-coupled device (“

CCD”

), complementary metal oxide semiconductor (“

CMOS”

) detector, and focal plane array sensor.

11. The method of claim 10 wherein said first data set comprises at least one row of information from said CCD.

12. The method of claim 11 wherein the adjusting comprises adjusting at least one row information from said CCD.

13. The method of claim 9 wherein the comparing comprises a correlation of said first and second data sets.

14. The method of claim 9 wherein said second data set is representative of a calibrated image of said substance.

15. The method of claim 9 further comprising:

obtaining a third data set representative of a first spectrum of said substance from one of said plural fibers wherein said first spectrum comprises at least one peak;

providing a fourth data set representative of a second spectrum of said substance wherein said second spectrum comprises at least one peak;

comparing a part of said third data set representative of at least one peak of said first spectrum to a part of said fourth data set representative of at least one peak of said second spectrum; and

adjusting said third data set based on said comparison of said third and fourth data sets.

16. The method of claim 15 wherein said fourth data set is representative of a reference spectrum of said substance.

17. A method for spectral calibration, comprising:

obtaining a first image of a known substance using a photon detector and a fiber array spectral translator having plural fibers, wherein said first image comprises at least one pixel;

providing a second image of said substance wherein said second image comprises at least one pixel;

obtaining a first spectrum of said substance from one of said plural fibers wherein said first spectrum comprises at least one peak;

providing a second spectrum of said substance wherein said second spectrum comprises at least one peak;

comparing said first image with said second image to thereby obtain a bulk shift adjustment; and

comparing at least one peak of said first spectrum to at least one peak of said second spectrum to thereby obtain a subpixel adjustment.

18. The method of claim 17 wherein said photon detector is selected from the group consisting of:

charge-coupled device (“

CCD”

), complementary metal oxide semiconductor (“

CMOS”

) detector, and focal plane array sensor.

19. The method of claim 17 wherein the comparing of said first and second images comprises a correlation of said first and second images.

20. The method of claim 17 wherein said second image is a calibrated image of said substance.

21. The method of claim 17 wherein said second spectrum is a reference spectrum of said substance.

22. A method for spectral calibration, comprising:

obtaining a first data set representative of a first image of a known substance using a photon detector and a fiber array spectral translator having plural fibers, wherein said first image comprises at least one pixel;

providing a second data set representative of a second image of said substance, wherein said second image comprises at least one pixel;

obtaining a third data set representative of a first spectrum of said substance from one of said plural fibers wherein said first spectrum comprises at least one peak;

providing a fourth data set representative of a second spectrum of said substance wherein said second spectrum comprises at least one peak;

comparing said first data set with said second data set to thereby obtain a bulk shift adjustment; and

comparing said third data set with said fourth data set to thereby obtain a subpixel adjustment.

23. The method of claim 22 wherein said photon detector is selected from the group consisting of:

charge-coupled device (“

CCD”

), complementary metal oxide semiconductor (“

CMOS”

) detector, and focal plane array sensor.

24. The method of claim 22 wherein the comparing of said first and second data sets comprises a correlation of said first and second data sets.

25. The method of claim 22 wherein said second data set is representative of a calibrated image of said substance.

26. The method of claim 22 wherein said fourth data set is representative of a reference spectrum of said substance.

27. A system for spectral calibration of a known substance, comprising:

a photon source for illuminating said substance with first photons to thereby produce second photons;

a fiber array spectral translator having plural fibers, wherein said fiber array spectral translator receives said second photons;

a photon detector operatively connected to said fiber array spectral translator, wherein said photon detector detects said second photons;

a memory unit comprising a first data set representative of a first image of said substance;

a microprocessor unit operatively connected to said photon detector and said memory unit, wherein said microprocessor obtains a second data set from said second photons, compares said first and second data sets, and adjusts said first data set based on said comparison.

28. The system of claim 27 further comprising a display device operatively connected to said microprocessor unit so as to display an image selected from the group consisting of:

said first image, a second image representative of said second data set, an adjusted image representative of said adjusted first data set, and combinations thereof.

29. The system of claim 27 wherein said photon detector is selected from the group consisting of:

charge-coupled device (“

CCD”

), complementary metal oxide semiconductor (“

CMOS”

) detector, and focal plane array sensor.

30. The system of claim 29 wherein said second image comprises at least one row of pixels from said CCD.

31. The system of claim 30 wherein said microprocessor unit adjusts at least one row of said second image.

32. The system of claim 27 wherein said microprocessor compares said first and second data sets by correlating said first and second data sets.

33. The system of claim 27 wherein said first image is a calibrated image of said substance.