Method and apparatus for collecting a blood component and performing a photopheresis treatment
First Claim
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1. An apparatus comprising a cassette for controlling movement of blood and separated blood components, the cassette comprising a housing formed by joining a rigid plastic cover and a rigid plastic base;
- said rigid plastic cover having a top surface, a bottom surface, and a wall having a plurality of openings;
said rigid plastic base having a top surface, a bottom surface, and a plurality of apertures through the top and bottom surfaces, and a wall having a plurality of openings adapted to overlap with the openings of the wall of the cover;
said top surface of the base comprises a first upper level and a first lower level, wherein the first lower level has a plurality of first flexible tubings, secured by raceways, for one or more of a) connecting to other tubings through multitube connectors, b) extending out of or entering the housing, or c) forming first flexible tube loops having one end extending out of the housing and one end entering the housing;
said plurality of apertures are located on the first lower level and expose at least one section of the first flexible tubing inside the housing so that fluid flow through the exposed section can be prevented when an actuator exerts pressure on the exposed section through the apertures against a first occluder bar located above the first lower level surface;
said bottom surface of the base comprises a second upper level and a second lower level, wherein the second lower level has a plurality of second flexible tubings outside of the housing and secured by raceways on said second lower level for one or more of extending through or entering the openings of the wall of the base or forming second flexible tube loops having one end extending out of the wall and one end entering the wall of the base; and
wherein fluid flowing through the second flexible tubing can be prevented when another actuator exerts pressure on the tubing against a second occluder bar located on the second lower level of the bottom surface of the base.
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Abstract
Methods and apparatus for collecting and treating blood component. An apparatus and methods for improvement of an extracorporeal photopheresis treatment is described. A cassette having flexible tubes inside its housing and on the bottom surface outside the cassette housing for ease of manufacturing is operated with a centrifuge bowl having an inlet and two outlets, pressure domes for measuring pressures in tubes, an improved irradiation plate, and a dual chamber bag in an extracorporeal photopheresis treatment.
354 Citations
11 Claims
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1. An apparatus comprising a cassette for controlling movement of blood and separated blood components, the cassette comprising a housing formed by joining a rigid plastic cover and a rigid plastic base;
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said rigid plastic cover having a top surface, a bottom surface, and a wall having a plurality of openings;
said rigid plastic base having a top surface, a bottom surface, and a plurality of apertures through the top and bottom surfaces, and a wall having a plurality of openings adapted to overlap with the openings of the wall of the cover;said top surface of the base comprises a first upper level and a first lower level, wherein the first lower level has a plurality of first flexible tubings, secured by raceways, for one or more of a) connecting to other tubings through multitube connectors, b) extending out of or entering the housing, or c) forming first flexible tube loops having one end extending out of the housing and one end entering the housing; said plurality of apertures are located on the first lower level and expose at least one section of the first flexible tubing inside the housing so that fluid flow through the exposed section can be prevented when an actuator exerts pressure on the exposed section through the apertures against a first occluder bar located above the first lower level surface; said bottom surface of the base comprises a second upper level and a second lower level, wherein the second lower level has a plurality of second flexible tubings outside of the housing and secured by raceways on said second lower level for one or more of extending through or entering the openings of the wall of the base or forming second flexible tube loops having one end extending out of the wall and one end entering the wall of the base; and
wherein fluid flowing through the second flexible tubing can be prevented when another actuator exerts pressure on the tubing against a second occluder bar located on the second lower level of the bottom surface of the base. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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Specification