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Apparatus and method for performing nucleic acid analysis

  • US 7,476,503 B2
  • Filed: 09/16/2005
  • Issued: 01/13/2009
  • Est. Priority Date: 09/17/2004
  • Status: Active Grant
First Claim
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1. A nucleic acid sequencing method comprising:

  • subjecting a target nucleic acid molecule to a template-directed polymerization reaction to yield a nascent nucleic acid strand that is complementary to the target nucleic acid molecule in the presence of a plurality of types of nucleotides or nucleotide analogs, and a polymerization enzyme exhibiting strand-displacement activity, wherein said template-directed polymerization reaction processes an identical sequence of nucleotides in the target nucleic acid molecule more than once;

    registering a time sequence of incorporation of nucleotides or nucleotide analogs into the nascent nucleotide strand; and

    determining a sequence of nucleotides in the target sequence.

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