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Acidic insulin preparations having improved stability

DC CAFC
  • US 7,476,652 B2
  • Filed: 03/25/2005
  • Issued: 01/13/2009
  • Est. Priority Date: 06/18/2002
  • Status: Expired due to Term
First Claim
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1. A pharmaceutical formulation comprising Gly(A21), Arg(B31), Arg(B32)-human insulin;

  • at least one chemical entity chosen from polysorbate 20 and polysorbate 80;

    at least one preservative; and

    water,wherein the pharmaceutical formulation has a pH in the acidic range from 1 to 6.8.

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