Substituted aryl thioureas and related compounds; inhibitors of viral replication
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Abstract
The invention provides compounds and pharmaceutically acceptable salts of Formula I
wherein the variables A1, A2, R1, R2, V, W, X, Y, and Z are defined herein. Certain compounds of Formula I described herein which possess potent antiviral activity. The invention particularly provides compounds of Formula I that are potent and/or selective inhibitors of Hepatitis C virus replication. The invention also provides pharmaceutical compositions containing one or more compound of Formula I, or a salt, solvate, or acylated prodrug of such compounds, and one or more pharmaceutically acceptable carriers, excipients, or diluents.
The invention further comprises methods of treating patients suffering from certain infectious diseases by administering to such patients an amount of a compound of Formula I effective to reduce signs or symptoms of the disease or disorder. These infectious diseases include viral infections, particularly HCV infections. The invention is particularly includes methods of treating human patients suffering from an infectious disease, but also encompasses methods of treating other animals, including livestock and domesticated companion animals, suffering from an infectious disease.
Methods of treatment include administering a compound of Formula I as a single active agent or administering a compound of Formula I in combination with on or more other therapeutic agent.
86 Citations
23 Claims
- 1. A compound of Formula 1
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19. A compound or pharmaceutically acceptable salt thereof, in which the compound is selected from
1-(Benzofuran-2-carbonyl-3-(3-phenoxy-phenyl)-thiourea; -
1-(Benzofuran-2-carbonyl)-3-(3-benzyloxy-phenyl)-thiourea; 1-(Benzo[b]thiophene-2-carbonyl)-3-(3-benzyloxy-phenyl)-thiourea; 1-(3-Benzyloxy-phenyl)-3-(5-fluoro-1H-indole-2-carbonyl)-thiourea; 1-(5-Fluoro-benzofuran-2-carbonyl)-3-(4-phenoxy-phenyl)-thiourea; 1-(5-Fluoro-benzofuran-2-carbothioyl)-3-(4-phenoxy-phenyl)-thiourea; 1-(3-Benzyloxy-phenyl)-3-(2,3-dihydro-benzofuran-2-carbonyl)-thiourea; 1-(3-Benzyloxy-phenyl)-3-(2,3-dihydro-benzo[1,4]dioxine-2-carbonyl)-thiourea; 1-(3-Benzyloxy-phenyl)-3-(chroman-2-carbonyl)-thiourea; 1-(3-Benzyloxy-phenyl)-3-(quinoline-2-carbonyl)-thiourea; 1-(Furan-2-carbonyl)-3-(4-benzo[d]thiazol-2-yl-phenyl)-thiourea; 1-(Benzofuran-2-yl-carbonyl)-3-[5-(benzo[d]oxazol-2-yl)-2-methyl]phenylthiourea; 1-(Pyridin-3-carbonyl)-3-(4-benzo[d]thiazol-2-yl-phenyl)-thiourea; 1-[3-(2-chlorophenyl-5-methyl-isoxazol-4-yl)-carbonyl]-3-(4-ispropylphenyl)thiourea; Butyl 4-(3-(benzofuran-2-yl-carbonyl)thioureido)benzoate; 1-((Benzofuran-2-yl-carbonyl)-3-(4-(phenoxy)-phenyl)thiourea; 1-[(1-methyimidazol-2-yl) carbonyl]-3-(3-benzoxy-phenyl)thiourea; tert-butyl 2-(3-(benzyloxy)phenylcarbamothioylcarbamoyl)pyrrolidine-1-carboxylate; (S)-N-(3-(benzyloxy)phenylcarbamothioyl)-2,3-dihydrobenzo[b][1,4]dioxine-2-carboxamide; Butyl 4-(3-(pyrrolidin-1-yl) carbonyl)thioureido)benzoate; (S)-N-(3-(benzyloxy)phenylcarbamothioyl)-2,3-dihydrobenzo[b][1,4]dioxine2-carboxamide; Butyl 4-(3-(1-methyl-benzofuran-2-yl) carbonyl)thioureido)benzoate; 1((Benzofuran-2-yl-carbonyl)-3-(4-pentyloxy)-phenyl)thiourea; 1-((Benzofuran-2-yl-carbonyl)-3-(4-pentyl)-phenyl)thiourea; 1-((Benzofuran-2-yl-carbonyl)-3-(4-pentyloxy)-phenyl)thiourea; 1-((Benzofuran-2-yl-carbonyl)-3-(3-phenyl)-phenyl)thiourea; Isopropyl 4-(3-(benzofuran-2-yl) carbonyl)thioureido)benzoate; 1-((Benzofuran-2-yl-carbonyl)-3-(3-benzyl)-phenyl)thiourea; 1-((Benzofuran-2-yl-carbonyl)-3-(4-benzyl)-phenyl)thiourea; Isobutyl 4-(3-(benzofuran-2-yl) carbonyl)thioureido)benzoate; 1-((Benzofuran-2-yl-carbonyl)-3-(3-fluoro-4-(piperidin-1-yl)phenyl)-phenyl)thiourea; 1-((Benzofuran-2-yl-carbonyl)-3-(3-(3-methoxybenzyloxy))phenyl)-phenyl)thiourea; 1-((Benzofuran-2-yl-carbonyl)-3-(3-(2-Methoxybenzyloxy)phenyl)-thiourea; 1-((Benzofuran-2-yl-carbonyl)-3-(3-(cyclohexylmethoxy)phenyl)-thiourea; 1-((Benzofuran-2-yl-carbonyl)-3-(4-(5,6-dihydropyridin-1(2H)-yl))phenyl)-thiourea; 1-((5-Methoxy-benzofuran-2-yl-carbonyl)-3-(3-benzyloxy-phenyl)-thiourea; Butyl 4-(3-(5-chloro-benzofuran-2-yl)carbonyl)thioureido)benzoate; 1-(7-Methoxy-benzofuran-2-yl-carbonyl)-3-(3-methoxybenzyloxy)phenyl)-phenyl)thiourea; 1-(3-(Benzyloxy)phenyl)-3-(2-(pyridin-3-yloxy)acetyl)thiourea; 1-(4-oxo-4-H-chromen-2-yl-carbonyl)-3-(3-methoxybenzyloxy)phenyl)-phenyl)thiourea; 1-(3-(Benzyloxy)phenyl)-3-(2-(pyridin-2-yloxy)acetyl)thiourea; 1-(Pyridin-2-yl-carbonyl)-3-(3-methoxybenzyloxy)phenyl)-phenyl)thiourea; 1-(3-Chloro-benzo[b]thiophen-2-yl-carbonyl)-3-(3-ethoxybenzyloxy)phenyl)-phenyl)thiourea; 1-(5-Methylisoxazol-3-yl-carbonyl)-3-(3-ethoxybenzyloxy)phenyl)-phenyl)thiourea; 1-(2-Methyl-5-phenyl-furan-3-yl-carbonyl)-3-(3-ethoxybenzyloxy)phenyl)-phenyl)thiourea; 1-(3-Chloro-benzo[b]thiophen-2-yl-carbonyl)-3-(3-phenyloxy)phenyl)-phenyl)thiourea; 1-(3,5-Dimethylisoxazol-4-yl-carbonyl)-3-(3-phenyloxy)phenyl)-phenyl)thiourea; 1-(5-Methylisoxazol-3-yl-carbonyl)-3-(3-phenyloxy)phenyl)-phenyl)thiourea; Ethyl 1-(2-fluoro-4-(3-(benzofuran-2-yl-carbonyl)thioureido)phenyl)-4-phenylpiperidine-4-carboxylate; 1-(3-((R)-1-Phenylethoxy)phenyl)-3-(3-chloro-methylbenzo[b]thiophen-2-yl-carbonyl)thiourea; 1-(3-((R)-1-Phenylethoxy)phenyl)-3-(5-methylisoxazol-3-yl-carbonyl)thiourea; 1-(3-((S)-1-Phenylethoxy)phenyl)-3-(5-methylisoxazol-3-yl-carbonyl)-thiourea; 1-(3-(Phenethyloxy)phenyl)-3-(3-chloro-methylbenzo[b]thiophen-2-yl-carbonyl)-thiourea; 1-(3-(Phenethyloxy)phenyl)-3-(3,5-dimethylisoxazol-4-yl-carbonyl)-thiourea; 1-(3-(Phenethyloxy)phenyl)-3-(5-methylisoxazol-3-yl-carbonyl)-thiourea; 1-(3-(2,3-Dihydro-1H-inden-2-yloxy)phenyl)-3-(3,5-dimethylisoxazol-4-yl-carbonyl)thiourea; 1-(3-(2,3-Dihydro-1H-inden-2-yloxy)phenyl)-3-(5-methylisoxazol-3-yl-carbonyl)thiourea; 1-(2-Phenylbenzo[d][1,3]dioxol-6-yl)-3-(benzofuran-2-yl-carbonyl)thiourea; 1-(3-((S)-1-Phenylethoxy)phenyl)-3-(benzofuran-2-yl-carbonyl)-thiourea; 1-(3-(Phenethyloxy)phenyl)-3-(benzofuran-2-yl-carbonyl)-thiourea; 1-(3-(2,3-Dihydro-1H-inden-2-yloxy)phenyl)-3-(benzofuran-2-yl-carbonyl)thiourea; 1-(3-((R)-1-Phenylethoxy)phenyl)-3-(benzofuran-2-yl-carbonyl)thiourea; 1-(2,4-dimethylthiazol-5-yl-carbonyl)-3-(3-phenyloxy)phenyl)-phenyl)thiourea; 1-(1-methyl-pyrrol-2-yl-carbonyl)-3-(3-(benzyloxy)phenyl)thiourea; 1-(3-(Phenethyloxy)phenyl)-3-((2,7-dimethylpyrazolo[1,5-a]pyrimidin-6-yl)--carbonyl)-thiourea; 1-(3-(Phenethyloxy)phenyl)-3-(1-ethyl-3-methyl-1H-pyrazol-5-yl-carbonyl)-thiourea; 1-(3-(2,3-Dihydro-1H-inden-2-yloxy)phenyl)-3-(2,4-dimethylthiazol-5-yl-carbonyl)thiourea; 1-(3-(2,3-Dihydro-1H-inden-2-yloxy)phenyl)-3-((2,7-dimethylpyrazolo[1,5-a]pyrimidin-6-yl)-carbonyl)thiourea; 1-(3-(2,3-Dihydro-1H-inden-2-yloxy)phenyl)-3-(1-ethyl-3-methyl-1H-pyrazol-5-yl-carbonyl)thiourea; 1-(4-Methyl-1,2,3-thiadiazol-5-yl-carbonyl)-3-(3-phenyloxy)phenyl)-phenyl)thiourea; 1-(Benzo[d]thiazol-2-yl-carbonyl)-3-(3-phenyloxy)phenyl)-phenyl)thiourea; 1-(4-Methyl-1,2,3-thiadiazol-5-yl-carbonyl)-3-(3-(benzyloxy) phenyl)thiourea; 1-(Benzo[d]thiazol-2-yl-carbonyl)-3-(3-(benzyloxy) phenyl)thiourea; 1-(Benzofuran-2-yl-carbonyl)-3-(3-fluoro-5-pentoxy-phenyl)thiourea; 1-(2-Methyl-pyridin-3-yl-carbonyl)-3-(3-(benzyloxy) phenyl)thiourea; 1-(1-phenyl-1H-pyrazol-5-yl-carbonyl)-3-(3-(benzyloxy) phenyl)thiourea; 1-(1-phenyl-1H-pyrazol-5-yl)-3-((3-phenyloxy)phenyl)-phenyl)thiourea; 1-(2-Phenylbenzo[d][1,3]dioxol-6-yl)-3-(1-phenyl-1H-pyrazol-5-yl-carbonyl)thiourea; 1-(1-phenyl-1H-pyrazol-5-yl)-3-(4-pentoxy-phenyl)-phenyl)thiourea; 1-(1-phenyl-1H-pyrazol-5-yl)-3-((3-phenyloxy-phenyl)-phenyl)thiourea; 1-(Methylbenzo[b]thiophen-2-yl-carbonyl)-3-((4-pentoxy-phenyl)-phenyl)thiourea; 1-(isoxazol-5-yl-carbonyl)-3-(3-(benzyloxy)phenyl)thiourea; 1-(isoxazol-5-yl-carbonyl)-3-(3-(phenoxy)phenyl)thiourea; 1-(isoxazol-5-yl-carbonyl)-3-(4-(pentyl)phenyl)thiourea; 1-(isoxazol-5-yl-carbonyl)-3-(4-(pentoxy)phenyl)thiourea; N-(3-phenoxyphenylcarbamothioyl)-2-(pyridin-4-yl)thiazole-4-carboxamide; N-(4-pentylphenylcarbamothioyl)-2-(pyridin-4-yl)thiazole-4-carboxamide; 1-((3-(trifluoromethyl)phenyl)furan-2-yl-carbonyl)-3-(3-(benzyloxy)phenyl)thiourea; 1-((3-(trifluoromethyl)phenyl)furan-2-yl-carbonyl)-3-(3-(phenoxy)phenyl)thiourea; 1-(5-Bromo-benzofuran-2-yl-carbonyl)-3-(3-(benzyloxy)phenyl)thiourea; 1-(5-Bromo-benzofuran-2-yl-carbonyl)-3-(3-(phenoxy)phenyl)thiourea; 1-(5-Nitro-benzofuran-2-yl-carbonyl)-3-(3-(benzyloxy)phenyl)thiourea; 1-(5-Nitro-benzofuran-2-yl-carbonyl)-3-(3-(phenoxy)phenyl)thiourea; 1-(5-Nitro-benzofuran-2-yl-carbonyl)-3-(4-pentyl phenyl)thiourea; 1-(5-Nitro-benzofuran-2-yl-carbonyl)-3-(4-pentoxy phenyl)thiourea; 1-(Benzofuran-2-yl-carbonyl)-3-(4-(hex-1-ynyl)phenyl) thiourea; 1-(Benzofuran-2-yl-carbonyl)-3-(3-(2-(pyridin-3-yl)ethynyl)phenyl)thiourea; 1-(Benzofuran-2-yl-carbonyl)-3-(3-(2-(pyridin-3-yl)ethyl)phenyl)thiourea; 1-(Benzofuran-2-yl-carbonyl)-3-(3-(pyridin-2-yl)phenyl)thiourea; 1-(Benzofuran-2-yl-carbonyl)-3-(3-(pyridin-2-yl-oxy)-phenyl)thiourea; 1-(3,5-Dimethylisoxazole-4-yl-carbonyl)-3-(4-(hex-1-ynyl)phenyl)thiourea; 1-(3,5-Dimethylisoxazole-4-yl-carbonyl)-3-(3-(2-(pyridin-3-yl)ethynyl)phenyl)thiourea; 1-(Benzofuran-2-yl-carbonyl)-3-((3-(trifluoromethyl)benzyloxy)-phenyl)thiourea; 1-(Benzofuran-2-yl-carbonyl)-3-(4-((1-methylpiperidin-4-yl)methoxy)-3-fluorophenyl)thiourea; 1-(Benzofuran-2-yl-carbonyl)-3-(3-(trifluoromethyl)-4-(piperidin-1-yl)phenyl)thiourea; 1-(1,3-dimethyl-1H-thieno[2,3-c]pyrazol-5-yl-carbonyl)-3-(3-(phenoxy)phenyl)thiourea; 1(5-(2-methylthiazol-4-yl)isoxazol-3-yl-carbonyl)-3-(3-(benzyloxy)phenyl)thiourea; 1-(5-(2-methylthiazol-4-yl)isoxazol-3-yl-carbonyl)-3-(3-phenoxy-phenyl)thiourea; 1-(5-(2-methylthiazol-4-yl)isoxazol-3-yl-carbonyl)-3-(4-pentyl-phenyl)thiourea; 1-(5-(2-methylthiazol-4-yl)isoxazol-3-yl-carbonyl)-3-(4-pentoxy-phenyl)thiourea; 1-(1,5-Dimethyl-1H-pyrazol-3-yl-carbonyl)-3-(3-(benzyloxy)phenyl)thiourea; 1-(1,5-Dimethyl-1H-pyrazol-3-yl-carbonyl)-3-(3-(phenoxy)phenyl)thiourea; 1-(1,5-Dimethyl-1H-pyrazol-3-yl-carbonyl)-3-(4-pentyl-phenyl)thiourea; 1-(1,5-Dimethyl-1H-pyrazol-3-yl-carbonyl)-3-(4-pentoxy-phenyl)thiourea; 1-(1-Methyl-3-tert-butyl-1H-pyrazol-3-yl-carbonyl)-3-(3-(benzyloxy)phenyl)thiourea; 1-(1-Methyl-3-tert-butyl-1H-pyrazol-3-yl-carbonyl)-3-(3-(phenoxy) phenyl)thiourea; 1-(1-Methyl-3-tert-butyl-1H-pyrazol-3-yl-carbonyl)-3-(4-pentyl-phenyl)thiourea; 1-(2-Trifluoromethyl-5-methyl-furan-2-yl-carbonyl)-3-(3-(benzyloxy)-phenyl)thiourea; 1-(2-Trifluoromethyl-5-methyl-furan-2-yl-carbonyl)-3-(3-(phenoxy)-phenyl)thiourea; 1-(2-Trifluoromethyl-5-methyl-furan-2-yl-carbonyl)-3-(4-pentyl-phenyl)thiourea; 1-(Benzo[c][1,2,5]oxadiazol-5-yl-carbonyl)-3--(3-(benzyloxy)phenyl)thiourea; 1-(Benzo[c][1,2,5]oxadiazol-5-yl-carbonyl)-3-(3-(phenoxy)phenyl)thiourea; 1-(Benzo[c][1,2,5]oxadiazol-5-yl-carbonyl)-3-(4-(pentyl)phenyl)thiourea; 1-(Benzo[c][1,2,5]oxadiazol-5-yl-carbonyl)-3-(4-(pentoxy)phenyl)thiourea; 1-(2,7-Dimethylpyrazolo[1,5-a]pyrimidin-6-yl-carbonyl)-3-(3-(benzyloxy)-phenyl)thiourea; 1-(2,7-Dimethylpyrazolo[1,5-a]pyrimidin-6-yl-carbonyl)-3-(3-(phenoxy)-phenyl)thiourea; 1-(2,7-Dimethylpyrazolo[1,5-a]pyrimidin-6-yl-carbonyl)-3-(4-(pentyl)-phenyl)thiourea; 1-(3-Methylisoxazol-4-yl-carbonyl)-3-(3-(benzyloxy)-phenyl)thiourea; 1-(3-Methylisoxazol-4-yl-carbonyl)-3-(3-(phenoxy)-phenyl)thiourea; 1-(3-Methylisoxazol-4-yl-carbonyl)-3-(4-(pentyl)-phenyl)thiourea; 1-(3-Methylisoxazol-4-yl-carbonyl)-3-(4-(pentoxy)-phenyl)thiourea; 1-(5-Methyl-2-phenyl-2H-1,2,3-triazol-4-yl-carbonyl)-3-(3-(benzyloxy)-phenyl)thiourea; 1-(5-Methyl-2-phenyl-2H-1,2,3-triazol-4-yl-carbonyl)-3-(3-(phenoxy)-phenyl)thiourea; 1-(5-Chloro-3-methylbenzo[b]thiophen-2-yl-carbonyl)-3-(3-(benzyloxy)-phenyl)thiourea; 1-(5-Chloro-3-methylbenzo[b]thiophen-2-yl-carbonyl)-3-(3-(phenoxy)-phenyl)thiourea; 1-(1,3-Dimethyl-1H-pyrazol-5-yl-carbonyl)-3-(3-(benzyloxy)-phenyl)thiourea; 1-(1,3-Dimethyl-1H-pyrazol-5-yl-carbonyl)-3-(3-(phenoxy)-phenyl)thiourea; 1-(1,3-Dimethyl-1H-pyrazol-5-yl-carbonyl)-3-(4-(pentyl)-phenyl)thiourea; 1-(1,3-Dimethyl-1H-pyrazol-5-yl-carbonyl)-3-(4-(pentoxy)-phenyl)thiourea; 1-(2-(Pyridin-3-yl)thiazol-4-yl-carbonyl)-3-(3-(benzyloxy)-phenyl)thiourea; 1-(2-(Pyridin-3-yl)thiazol-4-yl-carbonyl)-3-(3-(phenyloxy)-phenyl)thiourea; 1-(2-(Pyridin-3-yl)thiazol-4-yl-carbonyl)-3-(4-(pentyl)-phenyl)thiourea; 1-(2-(Pyridin-3-yl)thiazol-4-yl-carbonyl)-3-(4-(pentoxy)-phenyl)thiourea; 1-(4-Methoxy-benzofuran-2-yl-carbonyl)-3-(4-(benzyloxy)-phenyl)thiourea; 1-(4-Methoxy-benzofuran-2-yl-carbonyl)-3-(3-fluoro-4-pentoxy-phenyl)thiourea; 1-(Benzofuran-2-yl-carbonyl)-3-(3,5-dibromo-4-(pent-4-enyloxy)phenyl)thiourea; 1-(Benzofuran-2-yl-carbonyl)-3-(3-((pyridin-3-yl)methyl)phenyl)thiourea; 1-(5-Iodo-beuzofuran-2-yl-carbonyl)-3-(3-(benzyloxy)phenyl)thiourea; 1-(5-Phenyl-benzofuran-2-yl-carbonyl)-3-(3-(benzyloxy)phenyl)thiourea; 1-(5-(2-Pyridyl)benzofuran-2-yl-carbonyl)-3-(3-(benzyloxy)phenyl)thiourea; 1-(3-Propoxy-pyridin-2-yl-carbonyl)-3-(4-(pentyl)phenyl)thiourea; 1-(2,5-Dichlorothiophen-3-yl-carbonyl)-3-(4-(pentoxy)-phenyl)thiourea; 1-(3-Methyl-5-(methylthio)-4-vinylthiophen-2-yl-carbonyl)-3-(4-(pentoxy)-phenyl)thiourea; 1-(3-Methyl-5-(methylthio)-4-vinylthiophen-2-yl-carbonyl)-3-(4-(benzyloxy)-phenyl)thiourea; 1-(5-(Methylthio)-thiophen-2-yl-carbonyl)-3-(4-(benzyloxy)-phenyl)thiourea; 1-(5,7-Dimethylpyrazolo[1,5-a]pyrimidin-2-yl-carbonyl)-3-(4-(benzyloxy)-phenyl)thiourea; 1-(2,5-Dichlorothiophen-3-yl-carbonyl)-3-(4-(phenoxy)-phenyl)thiourea; 1-(3-Methyl-5-(methylthio)-4-vinylthiophen-2-yl-carbonyl)-3-(4-(phenoxy)-phenyl)thiourea; 1-(5-(Methylthio)-thiophen-2-yl-carbonyl-3-(4-(phenoxy)-phenyl)thiourea; 1-(7-Fluoro-benzofuran-2-yl-carbonyl)-3-(4-(pentoxy)-phenyl)thiourea; 1-(7-Fluoro-benzofuran-2-yl-carbonyl)-3-(3-(benzyloxy)-phenyl)thiourea; 1-(2-(1,3-Dioxoisoindolin-2-yl)acetyl)-3-(3-phenoxyphenyl)thiourea; 1-(2-(1,3-Dioxoisoindolin-2-yl)acetyl)-3-(3-benzyloxyphenyl)thiourea; 1-(Benzofuran-2-yl-carbonyl)-3-(3-(benzyloxy)methyl-phenyl)thiourea; 1-(Benzofuran-2-yl-carbonyl)-3-(3-(phenylamino)methyl-phenyl)thiourea; 1-(Benzofuran-2-yl-carbonyl)-3-(4-(N-benzyl-N-methylamino)-3-fluorophenyl)thiourea; Phenyl 3-(3-((benzofuran-2-yl)-carbonyl)thioureido)benzoate; 1-(Quinoxalin-2-yl-carbonyl)-3-(3-phenoxy-phenyl)thiourea; 1-(Quinoxalin-2-yl-carbonyl)-3-(4-pentoxy-phenyl)thiourea; 1-(Quinoxalin-2-yl-carbonyl)-3-(4-pentyl-phenyl)thiourea; 1-(5-Cyano-benzofuran-2-yl-carbonyl)-3-(3-phenoxy-phenyl)thiourea; 1-(5-Cyano-benzofuran-2-yl-carbonyl)-3-(4-pentyl-phenyl)thiourea; 1-(4-Methyl-1,2,3-thiadiazol-5-yl-carbonyl)-3-(4-pentoxy-phenyl)thiourea; 1-(4-Methyl-1,2,3-thiadiazol-5-yl-carbonyl)-3-(4-pentoxy-phenyl)thiourea; Butyl 4-(3-(4-Methyl-1,2,3-thiadiazol-5-yl-)carbonyl)thioureido)benzoate; 1-(Pyrazin-2-yl-carbonyl)-3-(3-phenoxy-phenyl)thiourea; 1-(Pyrazin-2-yl-carbonyl)-3-(4-pentyl-phenyl)thiourea; 1-(Pyrazin-2-yl-carbonyl)-3-(4-pentoxy-phenyl)thiourea; 1-(3-Fluoro-4-(pentyloxy)phenyl)-3-(2-(1,3-dioxoisoindolin-2-yl)acetyl)thiourea; 1-(Benzofuran-2-yl-carbonyl)-3-(3-trifluoromethyl-4-pentoxy-phenyl)thiourea; 1-(1-Benzyl-1H-tetrazol-5-yl-carbonyl)-3-(3-(benzyloxy)-phenyl)thiourea; 1-(Benzofuran-2-yl-carbonyl)-3-(4-(N-methyl-N-pentylamino)-3-fluorophenyl)thiourea; 1-(1-Benzyl-1H-tetrazol-5-yl-carbonyl)-3-(4-pentyl-phenyl)thiourea; 1-(6-Trifluoromethyl-pyrid-3-yl-carbonyl)-3-(4-pentyl-phenyl)thiourea; 1-(6-Trifluoromethyl-pyrid-3-yl-carbonyl)-3-(4-pentoxy-phenyl)thiourea; 1-(5-(Trifluoromethyl)-2-phenyloxazol-4-yl-carbonyl)-3-(3-(benzyloxy)-phenyl)thiourea; 1-(5-(Trifluoromethyl)-2-phenyloxazol-4-yl-carbonyl)-3-(3-(phenoxy)-phenyl)thiourea; 1-(5-(2-Chloro-5-trifluoromethylphenyl)-furan-2-yl-carbonyl)-3-(4-(pentoxy)-phenyl)thiourea; 1-((5-Acetamidobenzofuran-2-yl)carbonyl)-3-(3-phenoxyphenyl)thiourea; 1-(3,5-Dimethylisoxazole-4-yl-carbonyl)-3-(4-pentyl-phenyl)thiourea; 1-(Benzofuran-2-yl-carbonyl)-3-((2,3,4,5,6-penta-fluorophenoxy)-phenyl)thiourea; Pentyl 2-phenyl-4-(3-(benzofuran-2-yl)thioureido)benzoate; 1-(3-Pyrid-3-yl-carbonyl)-3-(3-benzyloxy-phenyl)thiourea; 1-(3-Pyrid-3-yl-carbonyl)-3-(3-phenoxy-phenyl)thiourea; 1-(3-Pyrid-3-yl-carbonyl)-3-(4-pentoxy-phenyl)thiourea; 1-(3-Pyrid-3-yl-carbonyl)-3-(4-pentyl-phenyl)thiourea; 1-(2-Morpholinoacetyl)-3-(3-phenoxyphenyl)thiourea; 1-(2-Morpholinoacetyl)-3-(4-(pentyloxy)phenyl)thiourea; 1-(2-Morpholinoacetyl)-3-(4-(pentyl)phenyl)thiourea; 1-(4-(Pentyloxy)phenyl)-3-(2-(piperidin-1-yl)acetyl)thiourea; 1-(Benzofuran-2-yl-carbonyl)-3-(6-pentoxy-pyrid-3-yl)thiourea; 1-(3-Pyrid-3-yl-carbonyl)-3-(3-benzyloxy-phenyl)thiourea hydrochloride; 1-(3-Pyrid-3-yl-carbonyl)-3-(3-phenoxy-phenyl)thiourea hydrochloride; 1-(3-Pyrid-3-yl-carbonyl)-3-(4-pentyl-phenyl)thiourea hydrochloride; 1-(Benzofuran-2-yl-carbonyl)-3-(trifluoromethylthlo-phenyl)thiourea; 1-(3-(Piperidin-1-yl)propanoyl)-3-(4-pentylphenyl)thiourea; 1-(3-(Piperidin-1-yl)propanoyl)-3-(4-(pentyloxy)phenyl)thiourea; 1-(3-(Piperidin-1-yl)propanoyl)-3-(3-phenoxyphenyl)thiourea; 1-(3-Morpholinopropanoyl)-3-(4-(pentyloxy)phenyl)thiourea; 1-(1-Methylpiperidin-3-yl-carbonyl)-3-(4-(pentyloxy)phenyl)thiourea; 1-(1-Methylpiperidin-3-yl-carbonyl)-3-(4-(pentyloxy)phenyl)thiourea; 1-(2-(2-methylpiperidin-1-yl)acetyl)-3-(4-(pentyloxy)phenyl)thiourea; 1-(2-Oxo-4-phenyl-pyrrolidin-1-ylcarbonyl)-3-(3-benzyloxy-phenyl)thiourea; and 1-(5-Trifluoromethoxy-benzofuran-2-yl-carbonyl)-3-(3-benzyloxy-phenyl)thiourea.
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Specification