Method and apparatus for investigating force-deformation properties in muscles in walls of bodily hollow systems
First Claim
1. A method for investigating force-deformation properties in muscles walls of a bodily hollow system using a balloon, wherein (i) said system has an opening, (ii) said balloon is situated between a proximal end and a distal end of a catheter, (iii) said catheter comprises an inside canal, and (iv) said method comprises the steps of:
- (a) inflating said balloon until said balloon abuts the inner wall of said system, wherein the inflation is a stepwise distension or a ramp distension with controlled distension rates, such that said balloon and said catheter are fixed longitudinally in relation to said system, and subsequently(b) introducing a mechanical stimulus by the inflated balloon to the muscles in the walls, wherein said mechanical stimulus is introduced between the opening of said system and the distal end of the catheter through said canal,(c) measuring the change of a physical property of the balloon during inflation of the balloon, wherein said physical property is a dimensional state of the balloon itself, is correlated to a force induced to the balloon, or is a mutual state between the balloon and the wall of the system, whereby(i) data related to the total tissue properties is obtained from a distention test in the absence of an muscle relaxant, and(ii) data related to the passive tissue properties is obtained from a distention test in the presence of an muscle relaxant,(d) computing the data related to the active tissue properties from the data related to the passive tissue properties and the total tissue properties obtained from step (c) according to the equation;
total tissue properties=active tissue properties+passive tissue properties, and(e) deriving force-deformation diagrams from the data related to the passive tissue properties and the active tissue properties.
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Abstract
The invention relates to a method for investigating force-deformation properties in muscles in walls of bodily hollow systems. The invention also relates to an apparatus for performing such investigating force-deformation properties in muscles in walls of bodily hollow systems and the use of such apparatus. By the method and the apparatus it is possible from measurements made deriving data on force-deformation relationship in the walls of the hollow system in order to obtain knowledge on active and passive tissue properties.
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Citations
24 Claims
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1. A method for investigating force-deformation properties in muscles walls of a bodily hollow system using a balloon, wherein (i) said system has an opening, (ii) said balloon is situated between a proximal end and a distal end of a catheter, (iii) said catheter comprises an inside canal, and (iv) said method comprises the steps of:
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(a) inflating said balloon until said balloon abuts the inner wall of said system, wherein the inflation is a stepwise distension or a ramp distension with controlled distension rates, such that said balloon and said catheter are fixed longitudinally in relation to said system, and subsequently (b) introducing a mechanical stimulus by the inflated balloon to the muscles in the walls, wherein said mechanical stimulus is introduced between the opening of said system and the distal end of the catheter through said canal, (c) measuring the change of a physical property of the balloon during inflation of the balloon, wherein said physical property is a dimensional state of the balloon itself, is correlated to a force induced to the balloon, or is a mutual state between the balloon and the wall of the system, whereby (i) data related to the total tissue properties is obtained from a distention test in the absence of an muscle relaxant, and (ii) data related to the passive tissue properties is obtained from a distention test in the presence of an muscle relaxant, (d) computing the data related to the active tissue properties from the data related to the passive tissue properties and the total tissue properties obtained from step (c) according to the equation;
total tissue properties=active tissue properties+passive tissue properties, and(e) deriving force-deformation diagrams from the data related to the passive tissue properties and the active tissue properties. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23)
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24. A method for investigating force-deformation properties in muscles walls of a bodily hollow system using a balloon, wherein (i) said system has an opening, (ii) said balloon is situated between a proximal end and a distal end of a catheter, (iii) said catheter comprises an inside canal, and (iv) said method comprises the steps of:
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(a) inflating said balloon until said balloon abuts the inner wall of said system, wherein the inflation is a stepwise distension or a ramp distension with controlled distension rates, such that said balloon and said catheter are fixed longitudinally in relation to said system, and subsequently (b) introducing a mechanical stimulus by the inflated balloon to the muscles in the walls, wherein said mechanical stimulus is introduced between the opening of said system and the distal end of the catheter through said canal, (c) measuring the change of a physical state of said system during inflation of the balloon, wherein said physical state is correlated to a corresponding physical property of the balloon, or to a mutual state between the balloon and the wall of the system, whereby (i) data related to the total tissue properties is obtained from a distention test in the absence of an muscle relaxant, and (ii) data related to the passive tissue properties is obtained from a distention test in the presence of an muscle relaxant, (d) computing data related to the active tissue properties from the data related to the passive tissue properties and the total tissue properties obtained from step (c) according to the equation;
total tissue properties=active tissue properties+passive tissue properties, and(e) deriving force-deformation diagrams from the data related to the passive tissue properties and the active tissue properties, wherein the force-deformation diagrams comprise length-tension diagrams, tension-strain diagrams, and stress-strain diagrams under various conditions comprising during administration of drugs in animals or persons with diseases.
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Specification