Compositions and methods for identifying and targeting cancer cells of alimentary canal origin
First Claim
1. An in vitro method of screening an individual for metastatic colorectal cancer cells or primary and/or metastatic stomach or esophageal cancer cells comprising the steps of examining a sample of extraintestinal tissue and/or body fluids from an individual to detect the presence of CDX2 protein in cells in said sample wherein the presence of CDX2 protein indicates a possibility of metastatic colorectal cancer cells or primary and/or metastatic stomach or esophageal cancer cells in said sample.
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Abstract
Screening and diagnostic reagents, kits and methods for metastatic colorectal cancer or primary and/or metastatic stomach or esophageal cancer are disclosed. Vaccines compositions and methods of for treating and preventing metastatic colorectal cancer or primary and/or metastatic stomach or esophageal cancer are disclosed.
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Citations
32 Claims
- 1. An in vitro method of screening an individual for metastatic colorectal cancer cells or primary and/or metastatic stomach or esophageal cancer cells comprising the steps of examining a sample of extraintestinal tissue and/or body fluids from an individual to detect the presence of CDX2 protein in cells in said sample wherein the presence of CDX2 protein indicates a possibility of metastatic colorectal cancer cells or primary and/or metastatic stomach or esophageal cancer cells in said sample.
- 3. An in vitro method of detecting metastatic colorectal cancer in an individual diagnosed with primary colorectal cancer comprising the steps of examining a sample of extraintestinal tissue and/or body fluids from said individual to detect the presence of CDX2 protein in said sample wherein the presence of CDX2 protein in said sample indicates that the individual has metastatic colorectal cancer.
- 5. An in vitro method of confirming that a tumor cell removed from a patient suspected of having colorectal, stomach or esophageal cancer cells is a colorectal, stomach or esophageal tumor cell comprising the step of detecting the presence of CDX2 protein in a tumor cell wherein the presence of CDX2 protein indicates that the tumor cell is a colorectal, stomach or esophageal tumor cell.
- 7. A method of diagnosing metastatic esophageal cancer in an individual who has been diagnosed with primary esophageal cancer comprising the step of examining a sample of extraintestinal tissue and/or body fluids from an individual to detect the presence of CDX2 protein in the sample, wherein the presence of CDX2 protein indicates that the individual has metastatic esophageal cancer.
- 13. A method of diagnosing metastatic stomach cancer in an individual who has been diagnosed with primary stomach cancer comprising the steps of examining a sample of extraintestinal tissue and/or body fluids from an individual to detect the presence of CDX2 protein in said sample wherein the presence of CDX2 protein indicates that the individual has metastatic stomach cancer.
Specification