Reagents and methods useful for detecting diseases of the breast
First Claim
1. An isolated polypeptide having a sequence consisting of an amino acid sequence selected from the group consisting of SEQUENCE ID NO:
- 16, SEQUENCE ID NO;
17, SEQUENCE ID NO;
18, SEQUENCE ID NO;
19, SEQUENCE ID NO;
20, and fragments of SEQUENCE ID NOS;
16-20, wherein said fragments consist of a sequence having a length of 15 to 20 amino acids.
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Accused Products
Abstract
A set of contiguous and partially overlapping RNA sequences and polypeptides encoded thereby, designated as BS106 and transcribed from breast tissue is described. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the breast such as breast cancer. Also provided are antibodies which specifically bind to BS106-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific BS106 polypeptide, which molecules are useful for the therapeutic treatment of breast diseases, tumors or metastases.
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Citations
10 Claims
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1. An isolated polypeptide having a sequence consisting of an amino acid sequence selected from the group consisting of SEQUENCE ID NO:
- 16, SEQUENCE ID NO;
17, SEQUENCE ID NO;
18, SEQUENCE ID NO;
19, SEQUENCE ID NO;
20, and fragments of SEQUENCE ID NOS;
16-20, wherein said fragments consist of a sequence having a length of 15 to 20 amino acids. - View Dependent Claims (2, 3)
- 16, SEQUENCE ID NO;
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4. An assay kit for determining the presence of an antigen or antibody in a test sample, comprising a container containing a polypeptide having a sequence consisting of an amino acid sequence selected from the group consisting of SEQUENCE ID NO:
- 16, SEQUENCE ID NO;
17, SEQUENCE ID NO;
18, SEQUENCE ID NO;
19, SEQUENCE ID NO;
20 and fragments thereof, wherein said fragments consist of a sequence having a length of 15 to 20 amino acids. - View Dependent Claims (5, 10)
- 16, SEQUENCE ID NO;
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6. A method for producing a polypeptide comprising at least one epitope, said method comprising incubating host cells that have been transfected with an expression vector containing a polynucleotide sequence encoding a polypeptide, wherein said polypeptide comprises an amino acid sequence having a sequence consisting of an amino acid sequence selected from the group consisting of SEQUENCE ID NO:
- 16, SEQUENCE ID NO;
17, SEQUENCE ID NO;
18, SEQUENCE ID NO;
19, SEQUENCE ID NO;
20, and fragments thereof, wherein said fragments consist of a sequence having a length of 15 to 20 amino acids.
- 16, SEQUENCE ID NO;
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7. A method for detecting the presence of antibodies specific for an antigen in a test sample suspected of containing such antibodies, said method comprising:
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(a) contacting the test sample with a polypeptide derived from an amino acid sequence or fragment thereof having an amino acid sequence selected from the group consisting of SEQUENCE ID NO;
16, SEQUENCE ID NO;
17, SEQUENCE ID NO;
18, SEQUENCE ID NO;
19, SEQUENCE ID NO;
20, and fragments thereof, and further wherein said contacting is carried out for a time and under conditions sufficient to allow antigen/antibody complexes to form; and(b) detecting said complexes, and even still further wherein said fragments consist of a sequence having a length of 15 to 20 amino acids. - View Dependent Claims (8)
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9. A composition of matter comprising an isolated polypeptide, wherein said polypeptide has an amino acid sequence selected from the group consisting of SEQUENCE ID NO:
- 16, SEQUENCE ID NO;
17, SEQUENCE ID NO;
18 SEQUENCE ID NO;
19, SEQUENCE ID NO;
20, and fragments of SEQUENCE ID NOS;
16-20, wherein said fragments consist of a sequence having a length of 15 to 20 amino acids.
- 16, SEQUENCE ID NO;
Specification