Echo train preparation for fast spin-echo acquisition

• US 7,479,783 B2
• Filed: 03/29/2007
• Issued: 01/20/2009
• Est. Priority Date: 11/15/2006
• Status: Active Grant

• Current Assignee: Beth Israel Deaconess Medical Center, Inc. (Beth Israel Lahey Health, Inc.)
• Original Assignee: Beth Israel Deaconess Medical Center, Inc. (Beth Israel Lahey Health, Inc.)
• Inventors: Alsop, David
• Primary Examiner(s): Shrivastav; Brij B
• Application Number:
  US11/729,815
• Publication Number:
  US 20080111547A1
• Time in Patent Office: 663 Days
• Field of Search: 324300-322, 600407-455
• US Class Current: 324/307
• CPC Class Codes: G01R 33/5615 Echo train techniques involving acquiring plural, differently encoded, echo signals after one RF excitation, e.g. using gradient refocusing in echo planar imaging [EPI], RF refocusing in rapid acquisition with relaxation enhancement [RARE] or using both RF and gradient refocusing in gradient and spin echo imaging [GRASE]
• CPC Class Codes: G01R 33/5617 using RF refocusing, e.g. RARE

Abstract

In one aspect, a method of inducing nuclear magnetic resonance (NMR) signals from a region of an object to be imaged is provided. The method comprises applying to the region a preparation sequence configured to substantially establish a zero flip-angle pseudo steady state (PSS) for the region, applying to the region a transitioning sequence configured to transition the zero flip-angle PSS to a higher target flip-angle PSS, and applying a radio frequency (RF) pulse sequence configured to cause the region to emit detectable NMR signals.

Claims

1. A method of inducing nuclear magnetic resonance (NMR) signals from a region of an object to be imaged, the method comprising:

applying to the region a preparation sequence configured to substantially establish a zero flip-angle pseudo steady state (PSS) for the region;

applying to the region a transitioning sequence configured to transition the zero flip-angle PSS to a higher target flip-angle PSS; and

applying a radio frequency (RF) pulse sequence configured to cause the region to emit detectable NMR signals.

2. The method of claim 1, wherein the preparation sequence includes an RF preparation pulse sequence, wherein pulses in the preparation pulse sequence increase in magnitude during a first preparation interval and then decrease in magnitude during a second preparation interval subsequent to the first preparation interval.

3. The method of claim 2, wherein the envelope of the pulses in the preparation pulse sequence is generally sinusoidal in shape.

4. The method of claim 2, wherein the envelope of the pulses in the preparation pulse sequence is approximately symmetrical in time, the magnitude of the pulses increasing from zero to a maximum amplitude during the first preparation interval and decreasing back to zero during the second preparation interval.

5. The method of claim 2, wherein at least one of the pulses in the preparation pulse sequence is approximately shaped as a hyperbolic secant.

6. The method of claim 2, wherein the transitioning sequence includes an RF transitioning pulse sequence, wherein pulses in the transitioning pulse sequence increase in magnitude during a first transitioning interval.

7. The method of claim 6, wherein the pulses in the transitioning pulse sequence increase from a magnitude of zero to a maximum magnitude during the first transitioning interval.

8. The method of claim 7, wherein pulses in the transitioning pulse sequence maintain the maximum magnitude during a second transitioning interval subsequent the first transitioning interval.

9. The method of claim 6, wherein the transitioning pulse sequence is configured to transition the zero flip-angle PSS through a plurality of incrementally higher flip-angle pseudo steady states to establish the target flip-angle PSS.

10. The method of claim 6, wherein the transitioning pulse sequence is configured to establish a target flip-angle PSS of less than 180°

C.

11. The method of claim 6, wherein the transitioning pulse sequence is configured to establish a target flip-angle PSS of less than 90°

C.

12. The method of claim 6, wherein the transitioning pulse sequence is configured to establish a target flip-angle PSS of less than 50°

C.

13. The method of claim 6, wherein the transitioning pulse sequence is configured to establish a target flip-angle PSS of less than 30°

C.

14. The method of claim 6, wherein the RF pulse sequence configured to cause the region to emit detectable NMR signals includes a plurality of refocusing pulses configured to cause a flip-angle substantially equal to the target flip angle.

15. The method of claim 6, wherein the refocusing pulse sequence is at least one of a spin-echo, a fast spin-echo, and a rapid acquisition with relaxation enhancement (RARE) pulse sequence.

16. The method of claim 15, wherein an interval between pulses in the preparation pulse sequence is substantially half of a spin-echo period.

17. The method of claim 15, wherein an interval between pulses in the transitioning pulse sequence is substantially equal to a spin-echo period.

18. The method of claim 1, wherein the region comprises a region of a human body.

19. The method of claim 2, further comprising:

applying to the region a magnetic field B₀;

wherein the RF preparation pulse sequence is configured to establish the zero flip-angle PSS by aligning nuclear spins within the region such that the nuclear spins alternate direction along an orientation that is approximately parallel to the magnetic field B₀.

20. The method of claim 19, wherein the nuclear spins alternate direction in a square wave fashion as a function of location in the region and spin frequency.

21. An apparatus adapted to deliver sequences configured to cause a region of an object to be imaged to emit NMR signals, the apparatus comprising:

a transmit component adapted to provide radio frequency (RF) electromagnetic radiation to a region;

a reception component adapted to detect NMR signals emitted from the region; and

a controller adapted to operate the transmit component to provide a preparation sequence configured to substantially establish a zero flip-angle pseudo steady state (PSS) for the region, a transitioning sequence configured to transition an established zero flip-angle PSS to a higher target flip-angle PSS, and a radio frequency (RF) pulse sequence configured to cause the region to emit detectable NMR signals.

22. The apparatus of claim 21, wherein the preparation sequence includes an RF preparation pulse sequence, wherein pulses in the preparation pulse sequence increase in magnitude during a first preparation interval and then decrease in magnitude during a second preparation interval subsequent to the first preparation interval.

23. The apparatus of claim 22, wherein the envelope of the pulses in the preparation pulse sequence is generally sinusoidal in shape.

24. The apparatus of claim 22, wherein the envelope of the pulses in the preparation pulse sequence is approximately symmetrical in time, the magnitude of the pulses increasing from zero to a maximum amplitude during the first preparation interval and decreasing back to zero during the second preparation interval.

25. The apparatus of claim 22, wherein at least one of the pulses in the preparation pulse sequence is approximately shaped as a hyperbolic secant.

26. The apparatus of claim 22, wherein the transitioning sequence includes an RF transitioning pulse sequence, wherein pulses in the transitioning pulse sequence increase in magnitude during a first transitioning interval.

27. The apparatus of claim 26, wherein the pulses in the transitioning pulse sequence increase from a magnitude of zero to a maximum magnitude during the first transitioning interval.

28. The apparatus of claim 27, wherein pulses in the transitioning pulse sequence maintain the maximum magnitude during a second transitioning interval subsequent the first transitioning interval.

29. The apparatus of claim 26, wherein the transitioning pulse sequence is configured to transition the zero flip-angle PSS through a plurality of incrementally higher flip-angle pseudo steady states to establish the target flip-angle PSS.

30. The apparatus of claim 29, wherein the transitioning pulse sequence is configured to establish a target flip-angle PSS of less than 180°

C.

31. The apparatus of claim 29, wherein the transitioning pulse sequence is configured to establish a target flip-angle PSS of less than 90°

C.

32. The apparatus of claim 29, wherein the transitioning pulse sequence is configured to establish a target flip-angle PSS of less than 50°

C.

33. The apparatus of claim 29, wherein the transitioning pulse sequence is configured to establish a target flip-angle PSS of less than 30°

C.

34. The apparatus of claim 26, wherein the RF pulse sequence configured to cause the region to emit detectable NMR signals includes a plurality of refocusing pulses configured to cause a flip-angle substantially equal to the target flip angle.

35. The apparatus of claim 26, wherein the refocusing pulse sequence is at least one of a spin-echo, a fast spin-echo, and a rapid acquisition with relaxation enhancement (RARE) pulse sequence.

36. The apparatus of claim 35, wherein an interval between pulses in the preparation pulse sequence is substantially half of a spin-echo period.

37. The apparatus of claim 35, wherein an interval between pulses in the transitioning pulse sequence is substantially equal to a spin-echo period.

38. The apparatus of claim 21, wherein the region comprises a region of a human body.

39. The apparatus of claim 22, further comprising a magnet capable of applying to the region a magnetic field B₀, and wherein the RF preparation pulse sequence is configured to establish the zero flip-angle PSS by aligning nuclear spins within the region such that the nuclear spins alternate direction along an orientation that is approximately parallel to the magnetic field B₀.

40. The apparatus of claim 39, wherein the nuclear spins alternate direction in a square wave fashion as a function of location in the region and spin frequency.

41. The apparatus of claim 21, wherein the transmit component includes an RF out signal generator and an RF coil array having at least one RF coil array, wherein the signal generator provides power to the RF coil array to provide the RF electromagnetic energy.

42. The apparatus of claim 41, wherein the receive component includes the RF coil array and a measurement component to detect disturbances in the RF coil array caused by the NMR signals emitted from the region.