Electro-optical stimulation/measurement

• US 7,480,433 B2
• Filed: 02/14/2003
• Issued: 01/20/2009
• Est. Priority Date: 02/19/2002
• Status: Active Grant

• Current Assignee: Tufts University
• Original Assignee: Tufts University
• Inventors: Walt, David R., Szunerits, Sabine
• Primary Examiner(s): Font; Frank G
• Assistant Examiner(s): Wong; Eric
• Application Number:
  US10/503,995
• Publication Number:
  US 20060013543A1
• Time in Patent Office: 2,167 Days
• Field of Search: 385115-121
• US Class Current: 385/116
• CPC Class Codes: A61B 5/0071 by measuring fluorescence emission
• CPC Class Codes: A61N 1/205 for promoting a biological process
• CPC Class Codes: A61N 2005/063 comprising light transmitting means, e.g. optical fibres
• CPC Class Codes: A61N 5/0613 Apparatus adapted for a specific treatment
• CPC Class Codes: A61N 5/0622 Optical stimulation for exciting neural tissue
• CPC Class Codes: B82Y 15/00 Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
• CPC Class Codes: B82Y 30/00 Nanotechnology for materials or surface science, e.g. nanocomposites
• CPC Class Codes: G01D 5/268 using optical fibres G01D5/28 - G01D5/38 take precedence
• CPC Class Codes: G01N 21/66 electrically excited, e.g. electroluminescence

Abstract

An electro-optical system includes an array including a plurality of optical fibers and a plurality of electrodes, and an insulator. The optical fibers are configured to transmit light, the optical fibers being mechanically coupled at distal ends in a distal arrangement and mechanically coupled at proximal ends in a proximal arrangement. The plurality of electrodes are substantially coaxially disposed with at least portions of corresponding optical fibers, the electrodes being electrically conductive, with the electrodes and optical fibers being disposed in pairs, thereby being pair components, with one of the pair components of each pair being disposed about a radial periphery of the other pair component. The insulator is disposed between the plurality of electrodes and configured to inhibit transfer of electrical energy between the plurality of electrodes.

Claims

1. An electro-optical system comprising:

an array comprising;

a plurality of optical fibers configured to transmit light, the optical fibers being mechanically coupled at distal ends in a distal arrangement and mechanically coupled at proximal ends in a proximal arrangement; and

a plurality of electrodes substantially coaxially disposed with at least portions of corresponding optical fibers, the electrodes being electrically conductive, with the electrodes and optical fibers being disposed in pairs, thereby being pair components, with one of the pair components of each pair being disposed about a radial periphery of the other pair component; and

an insulator disposed between the plurality of electrodes and configured to inhibit transfer of electrical energy between the plurality of electrodes.

2. The system of claim 1 further comprising:

an electrical apparatus coupled to at least some of the plurality of electrodes and configured to at least one of transmit electrical energy to, and receive electrical energy from, the at least some of the plurality of electrodes; and

an optical apparatus configured and disposed to receive light from the proximal ends of the optical fibers.

3. The system of claim 2 wherein the electrical device is coupled to less than all the plurality of electrodes.

4. The system of claim 3 wherein the electrical device is coupled to a percentage of the electrodes such that diffusional overlap at distal ends of the electrodes will be substantially negligible.

5. The system of claim 4 wherein the electrical device is coupled to approximately 20-30% of the electrodes.

6. The system of claim 1 wherein the electrode of each pair is disposed about the radial periphery of the fiber of each pair.

7. The system of claim 6 wherein an edge-to-edge spacing between any two electrodes coupled to the electrical apparatus is greater than about 10 times a typical diameter of one the plurality of electrodes.

8. The system of claim 1 wherein the optical fiber of each pair is disposed about the radial periphery of the electrode of each pair.

9. The system of claim 8 wherein a center-to-center spacing between any two electrodes disposed coaxially with the at least some of the plurality of optical fibers is greater than about 10 times a typical diameter of one of the plurality of electrodes.

10. The system of claim 1 wherein the distal ends of the optical fibers correlate to the proximal ends of the optical fibers in a known manner.

11. The system of claim 1 wherein the distal arrangement and the proximal arrangement are substantially similar.

12. The system of claim 1 wherein the electrical apparatus is configured to at least one of transfer electrical energy to, and receive electrical energy from, the at least some of the plurality of electrodes as a group.

13. The system of claim 1 wherein the electrical apparatus is configured to at least one of transfer electrical energy to, and receive electrical energy from, the at least some of the plurality of electrodes individually.

14. The system of claim 1 wherein the electrodes comprise electrically-conductive material coating an outer surface of the optical fibers.

15. A method of stimulating and sensing an object, the method comprising:

providing energy in a first form to the object through at least one of a plurality of first energy transmitters disposed in a first array at least at distal ends of the first energy transmitters, the first form of energy being one of electrical and optical; and

sensing energy in a second form, produced by the object, through at least one of a plurality of second energy transmitters disposed in a second array at least at distal ends of the second energy transmitters, the first and second energy transmitters being mechanically coupled together and coaxially disposed at least at their distal ends, the second form of energy being one of electrical and optical, the second form of energy being different than the first form of energy.

16. The method of claim 15 wherein the first form of energy is electrical and the first energy transmitters are microelectrodes, and wherein the providing energy includes providing energy to all of the plurality of first energy transmitters.

17. The method of claim 15 wherein the first form of energy is electrical and the first energy transmitters are microelectrodes, and wherein the providing energy includes selectively providing energy to a portion of the plurality of first energy transmitters.

18. The method of claim 17 wherein the providing energy includes providing energy to the portion of the plurality of first energy transmitters such that diffusional overlap of the energy at distal ends of the portion of the plurality of first energy transmitters is substantially negligible.

19. The method of claim 15 wherein the first form of energy is electrical and the first energy transmitters are microelectrodes, and wherein the providing energy includes providing different amounts of energy to different ones of the plurality of first energy transmitters.

20. The method of claim 15 wherein either the first or the second energy transmitters are electrodes, the method further comprising providing electrical energy through the electrodes to kill living tissue in the object in a vicinity of distal ends of the electrodes.

21. The method of claim 15 further comprising processing the second energy to determine an image of at least a portion of the object.

22. The method of claim 15 further comprising providing energy in the second form to the object through at least one of the second energy transmitters.

23. The method of claim 22 wherein the providing energy in the first form and the providing energy in the second form occurs concurrently.

24. The method of claim 23 further comprising sensing energy in the first form concurrently with the sensing energy in the second form.

25. The method of claim 15 wherein the second energy transmitters are optical fibers, and the sensing includes sensing optical energy transmitted by at least two of the optical fibers.

26. The method of claim 15 wherein the first energy transmitters are optical fibers and the providing includes transmitting optical energy through less than all of the optical fibers.

27. An electro-optical actuator/sensor system comprising:

optical means for delivering light to an optical-fiber array;

electrical means for delivering electricity through an electrical array of microelectrodes, the electrical means comprising electrically-conductive cladding of the optical fibers in the optical-fiber array;

an electrical apparatus coupled to the electrical means and configured to transfer electrical energy between the electrical apparatus and selected ones of the microelectrodes; and

an optical apparatus configured and disposed to transfer light between the apparatus and the optical-fiber array.

28. The system of claim 27 wherein distal and proximal ends of the optical fibers and electrodes are coherently related.

29. The system of claim 27 wherein the electrical apparatus is coupled to transfer electrical energy to about 20-30% of the electrodes.

30. The system of claim 27 wherein distal ends of the electrodes are disposed proximate to distal ends of the optical fibers and are separated from each other such that diffusional overlap associated with the electrodes is substantially negligible.

31. An electro-optical array comprising:

an optical substrate configured to transmit light, the substrate defining a plurality of openings extending through a thickness of the substrate;

a plurality of electrodes disposed within the openings through the substrate; and

at least one electrical conductor coupled to a portion of the plurality of electrodes, the at least one electrical conductor being configured to couple to an apparatus for supplying current to, and receiving current from, the at least one electrical conductor.

32. The array of claim 31 further comprising a plurality of optical rings disposed within the plurality of openings between the substrate and the electrodes, the optical rings having a higher index of reflection than the substrate.

33. The array of claim 31 wherein the openings defined by the substrate extend substantially straight through the substrate.

34. The array of claim 31 wherein distal ends of the electrodes are disposed relative to each other in a distal arrangement, and proximal ends of the electrodes are disposed relative to each other in a proximal arrangement, and the distal and proximal arrangements are substantially similar.

35. The array of claim 31 wherein the portion of the electrodes is such that diffusional overlap from distal ends of the electrodes is substantially negligible.

36. The array of claim 35 wherein the portion of the electrodes comprises approximately 50% of the electrodes.

37. The array of claim 35 wherein the portion of the electrodes comprises approximately 20-30% of the electrodes.

38. A method of specifically stimulating a target cell in a population of non-target cells, comprising:

providing energy, using a portion of an array of energy transmitters, to cells that include said target cell and said non-target cells;

detecting an optical signal, using another portion of said array of energy transmitters, to identify said target cell; and

delivering an electrical current, using yet another portion of said array of energy transmitters, to said cell;

wherein said electrical current is substantially not delivered to a non-target cell and wherein said target cell is stimulated to transduce an intracellular or extracellular signal.

39. A method of specifically destroying a target cell in a population of non-target cells, comprising:

providing energy, using a portion of an array of energy transmitters, to cells that include said target cell and said non-target cells;

detecting an optical signal, using another portion of said array of energy transmitters, to identify said target cell; and

delivering an electrical current, using yet another portion of said array of energy transmitters, to said cell;

wherein said electrical current is substantially not delivered to a non-target cell and wherein said target cell is destroyed.