Catheter with physiological sensor

• US 7,481,774 B2
• Filed: 04/22/2003
• Issued: 01/27/2009
• Est. Priority Date: 03/05/1999
• Status: Expired due to Fees

• Current Assignee: Data Sciences U K Limited (International Business Machines Corporation)
• Original Assignee: Transoma Medical, Inc.
• Inventors: Zwiers, Lynn M., Drexler, Mark J., Mills, Perry A., Brockway, Brian P.
• Primary Examiner(s): Hindenburg; Max
• Assistant Examiner(s): HOEKSTRA, JEFFREY GERBEN
• Application Number:
  US10/420,388
• Publication Number:
  US 20030195428A1
• Time in Patent Office: 2,107 Days
• Field of Search: 600/561, 600/587, 600/485, 600/486, 600/466, 600/467, 600/468
• US Class Current: 600/561
• CPC Class Codes: A61B 5/036 by means introduced into body tracts A61B5/032 and A61B5/035 take precedence
• CPC Class Codes: A61B 5/283 Invasive

Abstract

The disclosed embodiments present improved catheters with physiological sensors. In one embodiment, the catheter includes, generally, a pressure transducer/electronics assembly connected to a pressure transmission catheter. The pressure transmission catheter includes a hollow tube made from a low compliance material. The distal end of the hollow tube is filled with a gel-like material or plug which acts as a barrier between the catheter liquid and the target fluid. The hollow tube is partially filled with a low viscosity liquid and is in fluid communication with the gel-like material and the pressure transducer. The pressure of the target fluid is transmitted to the liquid in the hollow tube through the gel-like material and/or the wall of the distal tip and is fluidically transmitted to the pressure transducer. The pressure transmission catheter may be inserted into a vessel lumen or into a lumen of a therapeutic or diagnostic catheter for biomedical applications.

Claims

1. A pressure sensing device comprising:

a pressure transducer; and

a pressure transmission catheter comprising;

an elongate structure formed to define an internal lumen extending from a distal sensing portion of the pressure transmission catheter to a proximal end of the pressure transmission catheter in fluid communication with the pressure transducer, wherein the pressure transmission catheter is constructed to provide no transfer of fluid between the internal lumen and space outside of the pressure sensing device;

a pressure-transmitting liquid contained within the internal lumen;

support structure formed to surround the internal lumen at the distal sensing portion to prevent collapse of the internal lumen by lateral pressure forces, the support structure further being formed to define a plurality of openings through the support structure, the plurality of openings comprising at least one opening that is laterally facing; and

diaphragm structure formed in relation to the support structure to provide a diaphragm portion for each of the support structure openings.

2. The pressure sensing device according to claim 1, wherein the diaphragm structure comprises a compliant membrane formed around at least lateral outside surfaces of the support structure and over any of the openings that are laterally facing.

3. The pressure sensing device according to claim 2, wherein one of the openings of the support structure is at a distal longitudinal end of the pressure transmission catheter.

4. The pressure sensing device according to claim 3, wherein the diaphragm structure comprises a gel plug to cover the opening in the support structure at the distal longitudinal end.

5. The pressure sensing device according to claim 1, wherein a plurality of the support structure openings are laterally facing.

6. The pressure sensing device according to claim 1, wherein the elongate structure comprises a material selected from the group consisting of polyamide, polyimide, impregnated plastic, polytetra fluoroethylene, polyethylene, polyurethane, polyvinyl chloride, and polypropylene.

7. The pressure sensing device according to claim 1, wherein the elongate structure comprises a metal selected from the group consisting of 316 stainless steel, Nitinol, titanium, MP35N, and MP52.

8. The pressure sensing device according to claim 1, wherein a distal end of the elongate structure comprises a thin-wall portion, the support structure is disposed over the thin-wall portion, and wherein pressure is referred though the laterally facing openings to the pressure transmitting fluid through the thin-wall portion.

9. The pressure sensing device according to claim 1, wherein the pressure transmitting liquid is selected from the group consisting of water, saline, fluorinated hydrocarbon, silicone oils, alcohols, and propylene glycol dispersed in water.

10. The pressure sensing device according to claim 1, wherein at least a portion of the elongate structure is electrically conductive.

11. The pressure sensing device according to claim 10, wherein the elongate structure is substantially covered with an insulating material.

12. The pressure sensing device according to claim 1, wherein a distal end of the elongate structure includes an electrically conductive portion which acts as an electrode for detecting an electric signal.

13. The pressure sensing device according to claim 12, and further including a conductor that is coupled to the electrically conductive portion and disposed along the length of the elongate structure.

14. The pressure sensing device according to claim 1, wherein at least two liquids are disposed within the internal lumen.

15. The pressure sensing device according to claim 1, wherein the pressure transmission catheter is adapted for implantation.

16. The pressure sensing device according to claim 1, further comprising an implantable housing, and wherein the pressure transducer is mounted within the implantable housing.

17. The pressure sensing device according to claim 1, wherein the pressure transducer is coupled to an electrical lead.

18. The pressure sensing device according to claim 17, wherein the electrical lead provides input power.

19. The pressure sensing device according to claim 17, wherein the electrical lead delivers output signals to a control system.

20. The pressure sensing device according to claim 17, wherein the electrical lead delivers output signals to a therapeutic system.

21. The pressure sensing device according to claim 1, wherein the elongate structure comprises a biocompatible material.

22. The pressure sensing device according to claim 1, wherein a distal end of the elongate structure further comprises a thin-wall portion.

23. The pressure sensing device according to claim 1, wherein at least two liquids are disposed within the internal lumen, and wherein the at least two liquids comprise:

a first liquid in communication with the pressure transducer; and

a second liquid in communication with the diaphragm structure and the first liquid, and wherein the first liquid and the second liquid are not soluble with each other and together substantially fill at least a portion of the internal lumen.

24. The pressure sensing device according to claim 1, wherein the diaphragm structure is comprised of a compliant material.

25. The pressure sensing device according to claim 1, wherein a distal end of the elongate structure includes a plurality of ribs.

26. The pressure sensing device according to claim 1, wherein the a distal end of the elongate structure further comprises a plurality of holes.

27. The pressure sensing device according to claim 26, wherein the diaphragm structure is disposed over the plurality of holes.

28. The pressure sensing device according to claim 1, further comprising a flexible tip comprising:

a coil having a first end and second end;

a rounded head; and

wherein the rounded head is coupled to the first end of the coil, and the second end of the coil is coupled to a distal end of the elongate structure.

29. The pressure sensing device according to claim 1, further comprising a flexible tip comprising:

a coil having a first end and a second end;

a rounded head;

a cone-shaped insert having a plurality of holes; and

wherein the rounded head is attached to the first end of the coil, and the second end of the coil is attached to the cone-shaped insert and wherein the cone-shaped insert is inserted into a distal end of the elongate structure.

30. The pressure sensing device according to claim 1, wherein the support structure is integral with a the distal end of the elongate structure.

31. The pressure sensing device according to claim 1, wherein the support structure is integral with a the distal end of the elongate structure, and wherein the plurality of openings comprise thin areas of the elongate structure tube where material was removed.

32. The pressure sensing device according to claim 1, wherein a distal end of the elongate structure comprises a thin-wall portion, the support structure is disposed interior of the thin-wall portion, and the diaphragm structure comprises the thin-wall portion.