Intra-aortic renal drug delivery catheter

• US 7,481,803 B2
• Filed: 04/23/2003
• Issued: 01/27/2009
• Est. Priority Date: 11/28/2000
• Status: Expired due to Fees

• Current Assignee: AngioDynamics, Inc.
• Original Assignee: FlowMedica, Inc. (AngioDynamics, Inc.)
• Inventors: Rosenthal, Michael H., Payne, Sam G., Pesotchinsky, Sophia, Kesten, Randy J., Kramer, Andrew K.
• Primary Examiner(s): Sirmons; Kevin C.
• Assistant Examiner(s): WITCZAK, CATHERINE
• Application Number:
  US10/422,624
• Publication Number:
  US 20040064089A1
• Time in Patent Office: 2,106 Days
• Field of Search: 604/8, 604/500, 604507-510, 604/517, 604/93.01, 604/94.01, 604/96.01, 604/264, 604/284, 604/6.16
• US Class Current: 604/507
• CPC Class Codes: A61K 31/55 having seven-membered rings, e.g. azelastine, pentylenetetrazole
• CPC Class Codes: A61M 2025/0034 characterized by elements which are assembled, connected or fused, e.g. splittable tubes, outer sheaths creating lumina or separate cores making of catheters A61M25/0009
• CPC Class Codes: A61M 2025/0035 characterized by a variable lumen cross-section by means of a resilient flexible septum or outer wall
• CPC Class Codes: A61M 2025/0036 with more than four lumina
• CPC Class Codes: A61M 2025/0037 characterized by lumina being arranged side-by-side
• CPC Class Codes: A61M 2025/0039 characterized by lumina being arranged coaxially
• CPC Class Codes: A61M 2025/004 characterized by lumina being arranged circumferentially
• CPC Class Codes: A61M 2025/105 having a balloon suitable for drug delivery, e.g. by using holes for delivery, drug coating or membranes
• CPC Class Codes: A61M 2025/1052 for temporarily occluding a vessel for isolating a sector
• CPC Class Codes: A61M 2025/1072 having balloons with two or more compartments
• CPC Class Codes: A61M 2025/1095 with perfusion means for enabling blood circulation while the balloon is in an inflated state or in a deflated state, e.g. permanent by-pass within catheter shaft
• CPC Class Codes: A61M 2025/1097 with perfusion means for enabling blood circulation only while the balloon is in an inflated state, e.g. temporary by-pass within balloon
• CPC Class Codes: A61M 25/005 with embedded materials for reinforcement, e.g. wires, coils, braids
• CPC Class Codes: A61M 25/10 Balloon catheters A61M25/0125 takes precedence; embolectomy A61B17/22032; retractors A61B17/02; inflatable balloons for placing stents or stent-grafts A61F2/958 ; stomach balloons for treatment of obesity A61F5/0003; oesophagal tubes A61J15/00
• CPC Class Codes: A61M 25/1002 characterised by balloon shape A61M25/1006, A61M25/1009 take precedence
• CPC Class Codes: A61M 25/1011 Multiple balloon catheters
• CPC Class Codes: A61M 29/02 Dilators made of swellable material balloon catheters for angioplasty A61M25/104
• CPC Class Codes: A61P 13/12 of the kidneys

Abstract

A catheter for delivering a therapeutic or diagnostic agent to a branch blood vessel of a major blood vessel, generally comprising an elongated shaft having at least one lumen in fluid communication with an agent delivery port in a distal section of the shaft, an expandable tubular member on the distal section of the shaft, and a radially expandable member on the tubular member. The tubular member is configured to extend within the blood vessel up-stream and down-stream of a branch vessel, and has an interior passageway which is radially expandable within the blood vessel to separate blood flow through the blood vessel into an outer blood flow stream exterior to the tubular member and an inner blood flow stream within the interior passageway of the tubular member.

Claims

1. A method for enhancing renal function in a patient, comprising:

separating a portion of aortic blood flowing into a location within an abdominal aorta into a first blood flow stream that flows along a first flow path substantially only into a plurality of renal arteries via a plurality of respective ostia having unique respective locations along the abdominal aorta wall and a second blood flow stream that flows along a second flow path across the renal artery ostia and into downstream circulation;

injecting a volume of fluid agent into the first flow path within the abdominal aorta at the location;

wherein the injected fluid agent is delivered substantially only into the plurality of renal arteries via the first flow path into their respective ostia while the second blood flow stream flows along the second flow path across the renal artery ostia and into downstream circulation; and

wherein the fluid agent being delivered into the plurality of renal arteries comprises a volume of nifedipine.

2. The method of claim 1, wherein the injected fluid agent is delivered substantially only into the plurality of renal arteries via their respective ostia simultaneously.

3. The method of claim 1, wherein the first flow path passes exterior to a tubular member, and the second blood flow path passes within an interior passageway of the tubular member.

4. The method of claim 3, wherein the tubular member tapers from a larger diameter downstream end to a smaller diameter upstream end.

5. The method of claim 3, further comprising inflating the tubular member.

6. A method for enhancing renal function in a patient, comprising:

separating a portion of aortic blood flowing into a location within an abdominal aorta into a first blood flow stream that flows along a first flow path substantially only into a plurality of renal arteries via a plurality of respective ostia having unique respective locations along the abdominal aorta wall and a second blood flow stream that flows along a second flow path across the renal artery ostia and into downstream circulation;

injecting a volume of fluid agent into the first flow path within the abdominal aorta at the location;

wherein the injected fluid agent is delivered substantially only into the plurality of renal arteries via the first flow path into their respective ostia while the second blood flow stream flows along the second flow path across the renal artery ostia and into downstream circulation; and

wherein the fluid agent being delivered into the plurality of renal arteries comprises a volume of Verapamil.

7. The method of claim 6, wherein the injected fluid agent is delivered substantially only into the plurality of renal arteries via their respective ostia simultaneously.

8. The method of claim 6, wherein the first flow path passes exterior to a tubular member, and the second blood flow path passes within an interior passageway of the tubular member.

9. The method of claim 8, wherein the tubular member tapers from a larger diameter downstream end to a smaller diameter upstream end.

10. The method of claim 8, further comprising inflating the tubular member.

11. A method for enhancing renal function in a patient, comprising:

separating a portion of aortic blood flowing into a location within an abdominal aorta into a first blood flow stream that flows along a first flow path substantially only into a plurality of renal arteries via a plurality of respective ostia having unique respective locations along the abdominal aorta wall and a second blood flow stream that flows along a second flow path across the renal artery ostia and into downstream circulation;

injecting a volume of fluid agent into the first flow path within the abdominal aorta at the location;

wherein the injected fluid agent is delivered substantially only into the plurality of renal arteries via the first flow path into their respective ostia while the second blood flow stream flows along the second flow path across the renal artery ostia and into downstream circulation; and

wherein the fluid agent being delivered into the plurality of renal arteries comprises a volume of Fenoldopam.

12. The method of claim 11, wherein the injected fluid agent is delivered substantially only into the plurality of renal arteries via their respective ostia simultaneously.

13. The method of claim 11, wherein the first flow path passes exterior to a tubular member, and the second blood flow path passes within an interior passageway of the tubular member.

14. The method of claim 13, wherein the tubular member tapers from a larger diameter downstream end to a smaller diameter upstream end.

15. The method of claim 13 further comprising inflating the tubular member.

16. A method for enhancing renal function in a patient, comprising:

separating a portion of aortic blood flowing into a location within an abdominal aorta into a first blood flow stream that flows along a first flow path substantially only into a plurality of renal arteries via a plurality of respective ostia having unique respective locations along the abdominal aorta wall and a second blood flow stream that flows along a second flow path across the renal artery ostia and into downstream circulation;

injecting a volume of fluid agent into the first flow path within the abdominal aorta at the location;

wherein the injected fluid agent is delivered substantially only into the plurality of renal arteries via the first flow path into their respective ostia while the second blood flow stream flows along the second flow path across the renal artery ostia and into downstream circulation; and

wherein the fluid agent being delivered into the plurality of renal arteries comprises a volume of a dopamine DA₁ agonist.

17. The method of claim 16, wherein the injected fluid agent is delivered substantially only into the plurality of renal arteries via their respective ostia simultaneously.

18. The method of claim 16, wherein the first flow path passes exterior to a tubular member, and the second blood flow path passes within an interior passageway of the tubular member.

19. The method of claim 18, wherein the tubular member tapers from a larger diameter downstream end to a smaller diameter upstream end.

20. The method of claim 18, further comprising inflating the tubular member.