Encapsulated covered stent

• US 7,481,835 B1
• Filed: 10/29/2004
• Issued: 01/27/2009
• Est. Priority Date: 10/29/2004
• Status: Expired due to Fees

• Current Assignee: Advanced Cardiovascular Systems Incorporated
• Original Assignee: Advanced Cardiovascular Systems Incorporated
• Inventors: Andreacchi, Anthony, Gada, Manish, Pacetti, Stephen Dirk, Le, Hung Manh
• Primary Examiner(s): GHERBI, SUZETTE JAIME J
• Application Number:
  US10/976,550
• Time in Patent Office: 1,551 Days
• Field of Search: 623/901, 623 111- 116
• US Class Current: 623/1.15
• CPC Class Codes: A61F 2/91 made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
• CPC Class Codes: A61F 2250/0067 Means for introducing or releasing pharmaceutical products into the body
• CPC Class Codes: A61L 2300/60 characterised by a special physical form
• CPC Class Codes: A61L 31/10 Macromolecular materials
• CPC Class Codes: A61L 31/16 Biologically active materials, e.g. therapeutic substances A61L31/047 takes precedence
• CPC Class Codes: Y10S 623/901 Method of manufacturing prosthetic device

Abstract

This disclosure provides a description of medical devices with polymeric cobwebbing disposed near the surfaces of the medical device. This cobwebbing can contain drug(s) and can enhance the mechanical and chemical function of intraluminal stents. Methods of using these devices and methods of preparing the devices are disclosed, as well.

Claims

1. A medical device, comprising an implantable portion with cutouts in the implantable portion that create a lattice structure having sidewalls and openings, and a plurality of polymer filaments between the sidewalls or between separate portions of the same sidewall wherein the filaments have an average diameter of 0.1 to 100 microns when the device is ready for delivery and wherein the polymer filaments block 10-90 percent of an opening formed by the cutout portion.

2. The medical device of claim 1 wherein the average diameter of the filaments is 0.2 to 80 microns.

3. The medical device of claim 1 wherein the average interfilament spacing is 0.2 to 80 microns when the device is ready for delivery.

4. The medical device of claim 1 wherein the average interfilament spacing is 0.5 to 10 microns.

5. The medical device of claim 1 wherein the polymer filaments block 20-80 percent of the opening formed by the cutout portion.

6. The medical device of claim 1 wherein the polymer filaments block 30-70 percent of the opening formed by the cutout portion.

7. The medical device of claim 6 wherein the medical device is a stent.

8. A method comprising inserting the medical device of claim 1 into a body lumen at a treatment position.

9. The method of claim 8 wherein the medical device is a stent.

10. The method of claim 9 wherein the filaments additionally comprise drug(s).

11. The method of claim 10 wherein the drug is selected from the group consisting of an antiproliferative, an antineoplastic, an antiinflammatory, an antiplatelet, an anticoagulant, an antifibrin, an antithrombin, an antimitotic, an antibiotic, an antioxidant and combinations thereof.

12. The method of claim 8 wherein the polymer filaments are selected from the group consisting of Elast-Eon 2 80A, polycarbonate urethanes, silicone urethanes, polyether urethanes, silicones, fluorosilicates, poly(ethylene-co-vinyl alcohol), poly(ethylene-co-vinyl acetate), poly(butyl methacrylate), poly(methacrylate), poly(acrylates), styrene-ethylene/butylene-styrene triblock copolymers, styrene-isobutylene-styrene triblock copolymers, poly(vinylidene fluoride), poly(vinylidene fluoride-co-hexafluoropropylene), poly(vinylidene fluoride-co-chlorotrifluoroethylene), and solvent soluble fluoropolymers.

13. A method of making the medical device of claim 6 comprising coating a medical device with a composition comprising a polymer wherein the step of coating comprises selecting any combination of process parameters such that polymer filaments form between the sidewalls.

14. The medical device of claim 1 wherein the medical device is a stent.

15. The medical device of claim 14 wherein the filaments additionally comprise drug(s).

16. The medical device of claim 15 wherein the drug is selected from antiproliferative, antineoplastic, antiinflammatory, antiplatelet, anticoagulant, antifibrin, antithrombin, antimitotic, antibiotic, or antioxidant substances, or their combinations.

17. The medical device of claim 14 wherein the polymer is selected from Elast-Eon 2 80A, polycarbonate urethanes, silicone urethanes, polyether urethanes, silicones, fluorosilicates, poly(ethylene-co-vinyl alcohol), poly(ethylene-co-vinyl acetate), poly(butyl methacrylate), poly(methacrylate), poly(acrylates), styrene-ethylene/butylene-styrene triblock copolymers, styrene-isobutylene-styrene triblock copolymers, poly(vinylidene fluoride), poly(vinylidene fluoride-co-hexafluoropropylene), poly(vinylidene fluoride-co-chlorotrifluoroethylene), and solvent soluble fluoropolymers.

18. A method of making the medical device of claim 1 comprising coating a medical device with a composition comprising a polymer wherein the step of coating comprises selecting any combination of process parameters such that polymer filaments form between the sidewalls.