Albumin fusion proteins
First Claim
1. An albumin fusion protein comprising a serum cholinesterase polypeptide fused to an albumin polypeptide, wherein said serum cholinesterase polypeptide is selected from:
- (a) a full-length serum cholinesterase;
(b) a mature serum cholinesterase; and
(c) a fragment of serum cholinesterase, wherein said fragment has serum cholinesterase activity;
and wherein said albumin polypeptide is selected from;
(i) a full-length albumin;
(ii) a mature albumin;
(iii) a fragment of albumin, wherein said fragment of albumin has the ability to prolong the serum half-life of the fused serum cholinesterase polypeptide compared to the unfused serum cholinesterase polypeptide;
(iv) a polypeptide consisting of an amino acid sequence at least 95% identical to SEQ ID NO;
18, wherein said polypeptide has the ability to prolong the serum half-life of the fused serum cholinesterase polypeptide compared to the unfused serum cholinesterase polypeptide;
(v) amino acids 1 to 585 of SEQ ID NO;
18; and
(vi) amino acids 1 to 387 of SEQ ID NO;
18.
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Abstract
The present invention encompasses albumin fusion proteins. Nucleic acid molecules encoding the albumin fusion proteins of the invention are also encompassed by the invention,as are vectors containing these nucleic acids, host cells transformed with these nucleic acids vectors, and methods of making the albumin fusion proteins of the invention and using these nucleic acids, vectors, and/or host cells. Additionally the present invention encompasses pharmaceutical compositions comprising albumin fusion proteins and methods of treating, preventing, or ameliorating diseases, disorders or conditions using albumin fusion proteins of the invention.
168 Citations
21 Claims
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1. An albumin fusion protein comprising a serum cholinesterase polypeptide fused to an albumin polypeptide, wherein said serum cholinesterase polypeptide is selected from:
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(a) a full-length serum cholinesterase; (b) a mature serum cholinesterase; and (c) a fragment of serum cholinesterase, wherein said fragment has serum cholinesterase activity; and wherein said albumin polypeptide is selected from; (i) a full-length albumin; (ii) a mature albumin; (iii) a fragment of albumin, wherein said fragment of albumin has the ability to prolong the serum half-life of the fused serum cholinesterase polypeptide compared to the unfused serum cholinesterase polypeptide; (iv) a polypeptide consisting of an amino acid sequence at least 95% identical to SEQ ID NO;
18, wherein said polypeptide has the ability to prolong the serum half-life of the fused serum cholinesterase polypeptide compared to the unfused serum cholinesterase polypeptide;(v) amino acids 1 to 585 of SEQ ID NO;
18; and(vi) amino acids 1 to 387 of SEQ ID NO;
18.- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21)
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Specification