Method for attachment of silylated molecules to glass surfaces
First Claim
Patent Images
1. A compound having a formula vii:
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[(R1)(R2)(R3)Si—
X-Z-CYNH]2Si (NHCYL-M)2
viiwherein R1, R2 and R3 independently represents C1-C6 alkoxy, C1-C6 alkyl, phenyl, or aryl substituted with one or more groups selected from the group consisting of C1-C6 alkyl and C1-C6 alkoxy;
L represents a linking group;
X represents linear or branched C1-C20 alkyl or aryl substituted with one or more groups selected from the group consisting of C1-C6 alkyl and C1-C6 alkoxy, optionally substituted with one or more heteroatoms comprising oxygen, nitrogen, or sulfur;
Y represents oxygen or sulfur; and
Z represents oxygen or NH; and
M represents a molecule, with the proviso that at least one of R1, R2, or R3 represents C1-C6 alkoxy.
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Abstract
A method for the efficient immobilization of silylated molecules such as silylated oligonucleotides or proteins onto unmodified surfaces such as a glass surface is provided. Also provided are compounds, devices, and kits for modifying surfaces such as glass surfaces.
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Citations
6 Claims
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1. A compound having a formula vii:
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[(R1)(R2)(R3)Si—
X-Z-CYNH]2Si (NHCYL-M)2
viiwherein R1, R2 and R3 independently represents C1-C6 alkoxy, C1-C6 alkyl, phenyl, or aryl substituted with one or more groups selected from the group consisting of C1-C6 alkyl and C1-C6 alkoxy;
L represents a linking group;
X represents linear or branched C1-C20 alkyl or aryl substituted with one or more groups selected from the group consisting of C1-C6 alkyl and C1-C6 alkoxy, optionally substituted with one or more heteroatoms comprising oxygen, nitrogen, or sulfur;
Y represents oxygen or sulfur; and
Z represents oxygen or NH; and
M represents a molecule, with the proviso that at least one of R1, R2, or R3 represents C1-C6 alkoxy.- View Dependent Claims (2, 3)
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4. A kit comprising a compound having a formula vii:
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[(R1)(R2)(R3)Si—
X-Z-CYNH]2Si (NHCYL-M)2
viiwherein R1, R2 and R3 independently represents C1-C6 alkoxy, C1-C6 alkyl, phenyl, or aryl substituted with one or more groups selected from the group consisting of C 1-C6 alkyl and C1-C6 alkoxy;
L represents a linking group;
X represents linear or branched C1-C20 alkyl or aryl substituted with one or more groups selected from the group consisting of C1-C6 alkyl and C1-C6 alkoxy, optionally substituted with one or more heteroatoms comprising oxygen, nitrogen, or sulfur;
Y represents oxygen or sulfur; and
Z represents oxygen or NH; and
M represents a molecule, with the proviso that at least one of R1, R2, or R3 represents C1-C6 alkoxy.- View Dependent Claims (5, 6)
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Specification